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11 条记录 (耗时 0.031 秒)

    Adenovirus formulations
    3.
    发明授权
    Adenovirus formulations 有权
    腺病毒制剂

    公开(公告)号：US07456009B2

    公开(公告)日：2008-11-25

    申请号：US11071095

    申请日：2005-03-03

    申请人： Robert K. Evans ,  David B. Volkin ,  Lynne A. Isopi

    发明人： Robert K. Evans ,  David B. Volkin ,  Lynne A. Isopi

    IPC分类号： C12N7/00 ,  C12N7/01 ,  C12N15/861 ,  A61K39/235

    CPC分类号： A61K9/0019 ,  A61K48/00 ,  A61K2039/525 ,  C12N2710/10343 ,  C12N2710/10351

    摘要： The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when stored in about the 2-8° C. range while also being compatible with parenteral administration. These formulations comprise a buffer, a sugar, a salt, a divalent cation, a non-ionic detergent, as well as a free radical scavenger and/or a chelating agent to inhibit free radical oxidation.

    摘要翻译： 本发明涉及用于基因治疗和/或疫苗应用的病毒制剂和相关药物产品。 本文公开的特别优选的病毒制剂是液体腺病毒制剂，其在约2-8℃范围内储存时显示出改善的稳定性，同时也与肠胃外给药相容。 这些制剂包含缓冲剂，糖，盐，二价阳离子，非离子洗涤剂，以及抑制自由基氧化的自由基清除剂和/或螯合剂。

    Ultra thin oxynitride and nitride/oxide stacked gate dielectrics fabricated by high pressure technology
    5.
    发明授权
    Ultra thin oxynitride and nitride/oxide stacked gate dielectrics fabricated by high pressure technology 失效
    通过高压技术制造的超薄氧氮化物和氮化物/氧化物层叠栅电介质

    公开(公告)号：US06228779B1

    公开(公告)日：2001-05-08

    申请号：US09187247

    申请日：1998-11-06

    申请人： John A. Bloom ,  Dim-Lee Kwong ,  Robert K. Evans ,  Bruce T. Acker

    发明人： John A. Bloom ,  Dim-Lee Kwong ,  Robert K. Evans ,  Bruce T. Acker

    IPC分类号： H01L2131

    CPC分类号： H01L21/28202 ,  H01L21/28211 ,  H01L29/513 ,  H01L29/518

    摘要： A dense and stable dielectric layer of silicon nitride and silicon dioxide suitable for use in transistors of ULSI circuits is fabricated by a high pressure process in which a nitride layer is first formed on a surface of a silicon substrate and then a silicon dioxide layer is formed on the silicon surface under the nitride layer. By placing the nitride layer above the silicon dioxide and next to a doped polysilicon gate, diffusion of dopant ions such as boron from the gate into the silicon dioxide is reduced. As semiconductor devices are scaled down, the thermal budget required for the process steps is reduced.

    摘要翻译： 适用于ULSI电路的晶体管的氮化硅和二氧化硅的致密且稳定的电介质层通过高压法制造，其中首先在硅衬底的表面上形成氮化物层，然后形成二氧化硅层 在氮化物层下的硅表面上。 通过将氮化物层放置在二氧化硅上方并且靠近掺杂的多晶硅栅极，减少了掺杂剂离子如硼从栅极扩散到二氧化硅中。 随着半导体器件的缩小，减少了工艺步骤所需的热量预算。

    5-azido-deoxyuridine compounds and method of synthesis of the same
    9.
    发明授权
    5-azido-deoxyuridine compounds and method of synthesis of the same 失效
    5-叠氮基脱氧尿苷化合物及其合成方法

    公开(公告)号：US4672111A

    公开(公告)日：1987-06-09

    申请号：US726145

    申请日：1985-04-23

    申请人： Boyd E. Haley ,  Robert K. Evans

    发明人： Boyd E. Haley ,  Robert K. Evans

    IPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/073 ,  C07H19/10

    CPC分类号： C07H19/10

    摘要： 5-azido-2-'-deoxyuridine nucleoside and nucleotide compounds and a method of producing them. The method involves reacting a 5'-deoxyuridine compound with nitrosonium tetrafluoroborate to produce a 5-nitro-deoxyuridine compound. The 5-nitro-deoxyuridine compound is reduced to a 5-amino-deoxyuridine compound in the presence of metallic zinc. The 5-amino-deoxyuridine compound is acidified and reacted with sodium nitrite to produce a 5-diazo-deoxyuridine compound. The diazo-deoxyuridine compound is then reacted with sodium azide to produce a 5-azido-deoxyuridine compound. The latter, in the monophosphate form, is further reacted with diphenylchlorophosphate to produce the photoactive triphosphate, 5-azido-2'-deoxyuridine-5'-triphosphate or 5-azido-dUTP. The photoactive compound, when added to DNA in an in vitro synthesis reaction, produces photoactive DNA.

    摘要翻译： 5-叠氮基-2'-脱氧尿苷核苷和核苷酸化合物及其制备方法。 该方法包括使5'-脱氧尿苷化合物与四氟硼酸亚硝鎓反应以产生5-硝基 - 脱氧尿苷化合物。 在金属锌存在下将5-硝基脱氧尿苷化合物还原成5-氨基脱氧尿苷化合物。 将5-氨基脱氧尿苷化合物酸化并与亚硝酸钠反应生成5-重氮 - 脱氧尿苷化合物。 然后将重氮 - 脱氧尿苷化合物与叠氮化钠反应以产生5-叠氮基 - 脱氧尿苷化合物。 后者以单磷酸盐形式进一步与氯磷酸二苯酯反应以产生光活性三磷酸，5-叠氮基-2'-脱氧尿苷-5'-三磷酸或5-叠氮基-dUTP。 当在体外合成反应中加入DNA时，光活性化合物产生光活性DNA。