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公开(公告)号：US20080182303A1
公开(公告)日：2008-07-31
申请号：US10576122
申请日：2004-10-20
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zillin Huang , William Greenberg
CPC分类号： C12P17/06 , C07D309/30
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译： 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。
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公开(公告)号：US20110059493A1
公开(公告)日：2011-03-10
申请号：US12763198
申请日：2010-04-19
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译： 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。
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公开(公告)号：US07700329B2
公开(公告)日：2010-04-20
申请号：US10576122
申请日：2004-10-20
申请人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
发明人： Brian Morgan , Mark Burk , Michael Levin , Zuolin Zhu , Jennifer Chaplin , Karen Kustedjo , Zilin Huang , William Greenberg
CPC分类号： C12P17/06 , C07D309/30
摘要： The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.
摘要翻译： 本发明提供了生产辛伐他汀和各种中间体的合成化学和化学酶学方法。 在一个方面，酶如水解酶，例如酯酶，用于本发明的方法中。
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公开(公告)号：US20100273659A1
公开(公告)日：2010-10-28
申请号：US12529340
申请日：2008-02-29
申请人： Grace DeSantis , Jennifer Chaplin , Ellen Chi , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden , Dan Robertson
发明人： Grace DeSantis , Jennifer Chaplin , Ellen Chi , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden , Dan Robertson
IPC分类号： C40B20/00 , C12N15/55 , C12N15/63 , C12N9/78 , C12P7/40 , C12P7/42 , C12P13/00 , C12P7/54 , C12P7/56 , C12P19/34 , C12Q1/68 , C12P1/00 , C12Q1/34
CPC分类号： C12P7/42 , C12N9/78 , C12P13/002 , C12P13/004 , C12P13/005 , C12P13/04 , C12P41/007
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
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