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公开(公告)号：US20190328511A1
公开(公告)日：2019-10-31
申请号：US16249844
申请日：2019-01-16
发明人： Ryan Packer , Brian D. Jensen , Anton E. Bowden
摘要： A prosthetic venous valve device is disclosed and described, having a valve base including a cylindrical shape with a lumen configured for axial blood flow, the valve base further including an anterograde end and a retrograde end, a pair of flexure pivots coupled to opposite sides of the valve base at the anterograde end, and a pair of leaflets opposingly positioned with respect to one another and each pivotally coupled to one of the pair of flexure pivots, the pair of leaflets being separated from one another in a default open position, wherein the pair of leaflets are structurally configured to pivot from the default open position toward one another to close the prosthetic venous valve to limit retrograde venous blood flow under normal physiologic venous conditions.
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公开(公告)号：US20150164664A1
公开(公告)日：2015-06-18
申请号：US14533979
申请日：2014-11-05
IPC分类号： A61F2/89
CPC分类号： A61F2/915 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2210/0014 , A61F2250/0036 , A61L31/122 , A61L31/146 , A61L2400/12 , B29C59/007 , B82Y40/00
摘要： A vascular stent assembly includes at least a first and a second strut, each including a thickness and a depth. The assembly includes a pair of end radii, with each of the first and second struts extending from one of the pair of end radii. A thickness of at least one of the first and second struts includes a tapering profile extending from one of the end radii to another of the end radii, the tapering profile following a continuously increasing or decreasing function through at least half a length of the at least one strut.
摘要翻译： 血管支架组件包括至少第一和第二支柱，每个支柱包括厚度和深度。 组件包括一对端部半径，第一和第二支柱中的每一个从一对端部半径中的一个延伸。 所述第一和第二支柱中的至少一个的厚度包括从所述端部半径之一延伸到所述端部半径中的另一个的锥形轮廓，所述锥形轮廓沿连续增加或减小的功能通过所述至少一半的长度 一个支柱
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公开(公告)号：US10517995B2
公开(公告)日：2019-12-31
申请号：US15801317
申请日：2017-11-01
IPC分类号： B32B3/00 , A61L27/50 , A61L27/30 , A61L27/04 , A61L31/02 , A61L31/08 , A61L31/14 , C09D1/00 , C01B32/168 , C01B32/16 , A61B17/00 , A61L27/08 , B82Y40/00 , B82Y5/00 , B82Y30/00
摘要： Superhydrophobic materials are disclosed and described, along with devices, surfaces, and associated methods. Such materials can be coated onto device surfaces, system surfaces, structures, and the like.
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4.发明申请POROUS MATERIAL FOR THERMAL AND/OR ELECTRICAL ISOLATION AND METHODS OF MANUFACTURE 审中-公开用于热和/或电隔离的多孔材料和制造方法公开(公告)号：US20140314998A1
公开(公告)日：2014-10-23
申请号：US14256460
申请日：2014-04-18
CPC分类号： H01B3/12 , H01B19/04 , Y10T428/24612 , Y10T428/249969
摘要： In a general aspect, an apparatus can include a substrate and a porous layer disposed on the substrate, the porous layer including a plurality of silica nanotubes. The silica nanotubes of the porous layer can be solid, partially hollow and/or hollow elongate silica structures.
摘要翻译： 在一般方面，装置可以包括基底和设置在基底上的多孔层，多孔层包括多个二氧化硅纳米管。 多孔层的二氧化硅纳米管可以是固体，部分中空和/或中空细长的二氧化硅结构。
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5.发明申请公开(公告)号：US20130177988A1
公开(公告)日：2013-07-11
申请号：US13681260
申请日：2012-11-19
IPC分类号： C12N13/00
CPC分类号： C12N15/8775 , C12N13/00 , C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell can include bringing into proximity outside of a cell a lance and a preselected biological material, charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance, and penetrating an outer portion of the cell with the lance and directing and inserting the lance into the cell but outside of the organelle. The method can further include discharging the lance to release at least a portion of the biological material, charging the lance with an opposite polarity and charge sufficient to electrophoretically drive at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.
摘要翻译： 提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。 在一个方面，例如，将生物材料引入细胞的细胞器的方法可以包括使细胞附着在喷枪和预选的生物材料的外部，用足够的极性和电荷对喷枪进行充电以电连接 预先选择的具有喷枪的尖端部分的生物材料，并且用喷枪穿透细胞的外部部分并且将喷枪引导并插入细胞中，但是在细胞器外部。 该方法还可以包括排出喷枪以释放生物材料的至少一部分，以相反的极性对喷枪进行充电，并充入足以将至少一部分生物材料电泳驱动到细胞器中，并将枪从 细胞。
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公开(公告)号：US10119151B2
公开(公告)日：2018-11-06
申请号：US14103618
申请日：2013-12-11
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
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公开(公告)号：US20160367388A1
公开(公告)日：2016-12-22
申请号：US15057935
申请日：2016-03-01
摘要： A vascular stent assembly includes at least a first and a second strut, each including a thickness and a depth. The assembly includes a pair of end radii, with each of the first and second struts extending from one of the pair of end radii. A thickness of at least one of the first and second struts includes a tapering profile extending from one of the end radii to another of the end radii, the tapering profile following a continuously increasing or decreasing function through at least half a length of the at least one strut.
摘要翻译： 血管支架组件包括至少第一和第二支柱，每个支柱包括厚度和深度。 组件包括一对端部半径，第一和第二支柱中的每一个从一对端部半径中的一个延伸。 所述第一和第二支柱中的至少一个的厚度包括从所述端部半径之一延伸到所述端部半径中的另一个的锥形轮廓，所述锥形轮廓沿连续增加或减小的功能通过所述至少一半的长度 一个支柱
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8.发明申请LANCE DEVICE AND ASSOCIATED METHODS FOR DELIVERING A BIOLOGICAL MATERIAL INTO A CELL 审中-公开LANCE设备和将生物材料递送到细胞中的相关方法公开(公告)号：US20140199765A1
公开(公告)日：2014-07-17
申请号：US14109668
申请日：2013-12-17
IPC分类号： C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.
摘要翻译： 提供了将生物材料递送到电池中的系统，装置和方法。 在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。 这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中 。 在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。
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公开(公告)号：US20220125577A1
公开(公告)日：2022-04-28
申请号：US17242198
申请日：2021-04-27
发明人： Ryan Packer , Brian D. Jensen , Anton E. Bowden
摘要： A prosthetic venous valve device is disclosed and described, having a valve base including a cylindrical shape with a lumen configured for axial blood flow, the valve base further including an anterograde end and a retrograde end, a pair of flexure pivots coupled to opposite sides of the valve base at the anterograde end, and a pair of leaflets opposingly positioned with respect to one another and each pivotally coupled to one of the pair of flexure pivots, the pair of leaflets being separated from one another in a default open position, wherein the pair of leaflets are structurally configured to pivot from the default open position toward one another to close the prosthetic venous valve to limit retrograde venous blood flow under normal physiologic venous conditions.
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公开(公告)号：US20170333232A1
公开(公告)日：2017-11-23
申请号：US15445770
申请日：2017-02-28
摘要： A vascular stent assembly includes at least a first and a second strut, each including a thickness and a depth. The assembly includes a pair of end radii, with each of the first and second struts extending from one of the pair of end radii. A thickness of at least one of the first and second struts includes a tapering profile extending from one of the end radii to another of the end radii, the tapering profile following a continuously increasing or decreasing function through at least half a length of the at least one strut.
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