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    FIBRONECTIN TYPE III DOMAIN PROTEINS WITH ENHANCED SOLUBILITY
    3.
    发明申请
    FIBRONECTIN TYPE III DOMAIN PROTEINS WITH ENHANCED SOLUBILITY 审中-公开
    具有增强溶解性的FIBRONECTIN型III型蛋白质

    公开(公告)号：US20150368319A1

    公开(公告)日：2015-12-24

    申请号：US14766036

    申请日：2014-02-05

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Aaron P Yamniuk ,  Stanley R. Krystek

    IPC分类号： C07K14/78

    摘要： Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.

    摘要翻译： 本文提供了包含修饰的纤连蛋白III型（Fn3）结构域的多肽，其中相应于SEQ ID NO：1的残基58的氨基酸被突变，并且其中溶解度相对于Fn3结构域的溶解度增强，其中氨基 对应于SEQ ID NO：1的残基58的酸没有突变。 还提供了包含多个多肽的文库和用于鉴定与靶标结合的多肽的方法。

    Fibronectin type III domain proteins with enhanced solubility
    8.
    发明授权
    Fibronectin type III domain proteins with enhanced solubility 有权

    公开(公告)号：US11512124B2

    公开(公告)日：2022-11-29

    申请号：US16999291

    申请日：2020-08-21

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Aaron P. Yamniuk ,  Stanley R. Krystek

    IPC分类号： C12N15/00 ,  C07K14/78

    摘要： Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.