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公开(公告)号:US08815951B2
公开(公告)日:2014-08-26
申请号:US11566171
申请日:2006-12-01
申请人: Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
发明人: Bruce D Hammock , Jiang Zheng , Christophe Morisseau , Kazuhiko Motoba , Mehran F. Moghaddam , Babak Borhan , David F. Grant , Jessica Greene , Marlene F. Sisemore , James Sanborn
摘要: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 is each independently C1-C20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
摘要翻译: 本发明提供在治疗高血压的治疗应用中抑制环氧化物水解酶的化合物。 用于实施本发明的一类优选的化合物具有式1所示的结构,其中Z是氧或硫,W是碳磷或硫,X和Y各自独立地是氮,氧或硫,并且X还可以是碳, 当X为氮时,R 1为R 4为氢,R 2为氢时,当X为硫或氧时不存在,当Y为氮时为R4,当Y为硫或氧时不存在,R 1和R 3为 各自独立地为C1-C20取代或未取代的烷基,环烷基,芳基,酰基或杂环。
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公开(公告)号:US06174695B1
公开(公告)日:2001-01-16
申请号:US09312207
申请日:1999-05-14
申请人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号: C12Q134
CPC分类号: C12Q1/34 , G01N2500/10
摘要: The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.
摘要翻译: 本发明提供了通过抑制环氧化物水解酶来治疗由多不饱和脂质代谢物介导的炎性疾病的方法,用于测定或筛选环氧化物水解酶抑制剂以抑制特异性和毒性的方法,以及花生四烯酸的新型生物活性四氢呋喃二醇,包括其抗体 。
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公开(公告)号:US5955496A
公开(公告)日:1999-09-21
申请号:US909523
申请日:1997-08-12
申请人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
发明人: Bruce D. Hammock , Mehran F. Moghaddam , Jeffrey M. Cheek , Babak Borhan , James Fergusson , David F. Grant , Jessica F. Greene , Kazuhiko Matoba , Jiang Zheng , Marlene F. Sisemore
IPC分类号: A61K31/155 , A61K31/20 , A61K31/336 , A61K31/34 , C07D307/12
CPC分类号: A61K31/7088 , A61K31/155 , A61K31/20 , A61K31/336 , G01N2500/10
摘要: The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.
摘要翻译: 本发明提供花生四烯酸的新型生物活性四氢呋喃二醇。
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