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1.发明授权Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss 有权用于诱导/刺激毛发生长和/或减缓脱发的嘧啶3-氧化物化合物公开(公告)号：US06291468B1
公开(公告)日：2001-09-18
申请号：US09360495
申请日：1999-07-23
IPC分类号： A61K706
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical —OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
摘要翻译： 含有头发生长/脱毛的美容/治疗组合物含有有效量的至少一种具有结构式（I）的2-氨基-4-烷基氨基嘧啶3-氧化物：其中R1是具有5至20个 碳原子，Z为氢原子或基团-OR2，其中R2为碳原子数为1〜12的烷基，或其酰基衍生物或其酸加成盐。
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2.发明授权公开(公告)号：US06653317B2
公开(公告)日：2003-11-25
申请号：US10301733
申请日：2002-11-22
IPC分类号： C07D23948
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical −OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
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3.发明授权Pyrimidine 3-oxide compounds for inducing/stimulating hair growth and/or retarding hair loss 有权用于诱导/刺激毛发生长和/或减缓脱发的嘧啶3-氧化物化合物公开(公告)号：US06511659B2
公开(公告)日：2003-01-28
申请号：US09874053
申请日：2001-06-06
IPC分类号： C07D23948
CPC分类号： C07D239/48 , A61K8/4953 , A61Q7/00
摘要： Hair growth-/hair loss-affecting cosmetic/therapeutic compositions contain an effective amount of at least one 2-amino-4-alkylaminopyrimidine 3-oxide having the structural formula (I): in which R1 is an alkyl radical having from 5 to 20 carbon atoms, and Z is either a hydrogen atom or a radical —OR2, wherein R2 is an alkyl radical having from 1 to 12 carbon atoms, or an acyl derivative or acid addition salt thereof.
摘要翻译： 含有头发生长/脱毛的美容/治疗组合物含有有效量的至少一种具有结构式（I）的2-氨基-4-烷基氨基嘧啶3-氧化物：其中R1是具有5至20个 碳原子，Z为氢原子或基团-OR2，其中R2为碳原子数1〜12的烷基，或其酰基衍生物或其酸加成盐。
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公开(公告)号：US06448285B1
公开(公告)日：2002-09-10
申请号：US09297636
申请日：1999-07-26
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地用于治疗雄激素依赖性疾病如脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸系的新化合物和含有它们的组合物。
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公开(公告)号：US06596753B2
公开(公告)日：2003-07-22
申请号：US10176674
申请日：2002-06-24
IPC分类号： A61K31405
CPC分类号： A61Q19/00 , A61K8/492 , A61Q7/00 , C07D209/42 , C07D209/60
摘要： The invention relates to the use, as active principle, in a physiologically acceptable medium, in a composition, of an effective amount of at least one compound of the indolecarboxylic family, this compound or these compositions being intended to treat disorders associated with overactivity of 5&agr;-reductase. These compounds or the compositions containing them are more particularly intended to treat androgen-dependent disorders such as, for example, seborrhoea and/or acne and/or hirsutism and/or androgenic alopecia. The invention also relates to novel compounds of the indolecarboxylic family and to compositions-containing them.
摘要翻译： 本发明涉及作为活性成分在生物学上可接受的介质中，在组合物中使用有效量的至少一种吲哚类羧酸化合物的化合物，该化合物或这些组合物旨在治疗与5α过度活性相关的疾病 - 还原酶。 这些化合物或含有它们的组合物更特别地旨在治疗雄激素依赖性疾病，例如，脂溢和/或痤疮和/或多毛症和/或雄激素性脱发。 本发明还涉及吲哚羧酸家族的新化合物和含有它们的组合物。
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公开(公告)号：US5968487A
公开(公告)日：1999-10-19
申请号：US897058
申请日：1997-07-18
IPC分类号： A61K8/00 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/49 , A61K8/92 , A61K31/425 , A61P17/00 , A61Q19/00 , A61Q19/02 , C07D417/12 , A61K7/48
CPC分类号： C07D417/12 , A61K8/49 , A61Q19/02 , Y10S424/05 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： The invention relates to a novel derivative of kojic acid of formula (I) and to its use, in a composition for topical application as a depigmenting and/or bleaching agent for skin: ##STR1## The invention also relates to a process for depigmenting and/or bleaching skin, which includes applying to the skin a composition that contains 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl 2-oxothiazolidine-4-carboxylate of formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（I）的曲酸的新型衍生物及其在局部用作皮肤脱色和/或漂白剂的组合物中的用途：本发明还涉及脱色和/或漂白的方法 皮肤，其包括向皮肤施用包含式（I）的5-羟基-4-氧代-4H-吡喃-2-基甲基2-氧代噻唑烷-4-羧酸酯或其药学上可接受的盐的组合物。
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公开(公告)号：US08853169B2
公开(公告)日：2014-10-07
申请号：US12037106
申请日：2008-02-26
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesizing them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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公开(公告)号：US20080146516A1
公开(公告)日：2008-06-19
申请号：US12037106
申请日：2008-02-26
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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公开(公告)号：US07358346B2
公开(公告)日：2008-04-15
申请号：US11110864
申请日：2005-04-21
IPC分类号： C07H15/00
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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公开(公告)号：US20050250708A1
公开(公告)日：2005-11-10
申请号：US11110864
申请日：2005-04-21
IPC分类号： A61K31/70 , A61K31/715
CPC分类号： C07H15/00
摘要： The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and/or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and/or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.
摘要翻译： 本发明涉及给定绝对构型的新型C-糖苷化合物，其合成方法和含有它们的组合物。 本发明还涉及这些C-糖苷化合物的化妆品用途，有利地刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基（有利地为透明质酸）和/或蛋白聚糖的糖胺聚糖的合成 含有透明质酸的蛋白聚糖，通过成纤维细胞和/或角质形成细胞。 本发明还涉及使用含有至少一种本发明的C-糖苷化合物的组合物来治疗角蛋白材料的美容方法。
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