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    Composition for preventing cancer comprising 2'-benzoyl-oxycinnamaldehyde
    6.
    发明申请
    Composition for preventing cancer comprising 2'-benzoyl-oxycinnamaldehyde 审中-公开
    包含2'-苯甲酰基 - 氧肉桂醛的用于预防癌症的组合物

    公开(公告)号：US20060035968A1

    公开(公告)日：2006-02-16

    申请号：US11019977

    申请日：2004-12-23

    申请人： Byoung-Mog Kwon ,  Dae-Yeul Yu ,  Eun-Yi Moon ,  Kwang-Hee Son ,  Dong Cho Han

    发明人： Byoung-Mog Kwon ,  Dae-Yeul Yu ,  Eun-Yi Moon ,  Kwang-Hee Son ,  Dong Cho Han

    IPC分类号： A61K31/235

    CPC分类号： A61K31/235

    摘要： Disclosed is a composition for preventing cancer comprising a compound represented by Chemical Formula 1, 2′-benzoyloxycinnamaldehyde (BCA). BCA has the effects of delaying tumor incidence and increasing immune cells in a transgenic mouse overexpressing H-ras oncogene playing a critical role in tumor cell growth. Thus, BCA is useful as a cancer preventive drug.

    摘要翻译： 公开了一种用于预防癌症的组合物，其包含由化学式1，2'-苯甲酰氧基肉桂醛（BCA）表示的化合物。 BCA具有延缓肿瘤发生率和增加免疫细胞的作用，这种转基因小鼠过表达H-ras癌基因在肿瘤细胞生长中发挥关键作用。 因此，BCA可用作癌症预防药物。

    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby
    10.
    发明申请
    High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby 审中-公开
    通过筛选caspase3和XIAP结合抑制剂之间的结合抑制剂的高通量筛选方法

    公开(公告)号：US20090318376A1

    公开(公告)日：2009-12-24

    申请号：US12304766

    申请日：2006-06-12

    申请人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    发明人： Bong Hyun Chung ,  Kwang-Hee Son ,  Moonil Kim ,  Kyoungsook Park ,  Byoung-Mog Kwon ,  Hyun Jung Junn ,  Dong Cho Han ,  Sun-Hee Jeon

    IPC分类号： A61K31/702 ,  G01N33/573 ,  C07H15/24

    CPC分类号： A61K31/702 ,  G01N33/574 ,  G01N2333/96469 ,  G01N2500/02

    摘要： The present invention relates to a high throughput screening method of a binding inhibitor between caspase3 and xIAP and chromomycin screened using the same, and more specifically, the present invention provides a method for screening anticancer substance, the method comprising the steps of reacting caspase3 or xIAP and candidate inhibitors of the binding between caspase3 and xIAP on a biochip for detecting caspase3:xIAP interaction, and selecting a candidate substance inhibiting the binding of caspase3 to xIAP as an anticancer substance, and an anticancer agent inhibiting caspase3:xIAP binding, which is screened by the above method. According to present invention, it is possible to develop a target-oriented anticancer agent focused on xIAP and caspase3, apoptosis-related proteins and thus it can be applied to tailored medication and combination therapy. Moreover, glycoside antibiotic chromomycin, screened by the present invention has inhibitory activity of the binding between xIAP and caspase3 involved in apoptosis, so that it can be used as a therapeutic agent for myelogenous leukemia and solid tumors.

    摘要翻译： 本发明涉及使用其筛选的胱天蛋白酶3和xIAP之间的结合抑制剂的高通量筛选方法，更具体地说，本发明提供了筛选抗癌物质的方法，所述方法包括以下步骤：使半胱天冬酶3或xIAP 以及用于检测胱天蛋白酶3：xIAP相互作用的生物芯片上的半胱天冬酶3和xIAP之间的结合的候选抑制剂，并且选择抑制半胱天冬酶3与作为抗癌物质的xIAP的结合的候选物质，以及抑制胱天蛋白酶3的抗癌剂：xIAP结合 通过上述方法。 根据本发明，可以开发聚焦于xIAP和caspase3的靶向抗癌剂，凋亡相关蛋白，因此可以应用于定制药物和联合治疗。 此外，通过本发明筛选的糖苷抗生素chromomycin具有抑制参与凋亡的xIAP和半胱天冬酶3之间的结合的活性，因此可以用作骨髓性白血病和实体瘤的治疗剂。