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    INTERMITTENT DOSING OF NITRIC OXIDE GAS
    4.
    发明申请
    INTERMITTENT DOSING OF NITRIC OXIDE GAS 审中-公开
    硝酸氧化物的间歇剂量

    公开(公告)号：US20110226241A1

    公开(公告)日：2011-09-22

    申请号：US13007273

    申请日：2011-01-14

    申请人： Alex STENZLER ,  Chris Miller ,  Bevin B. McMullin

    发明人： Alex STENZLER ,  Chris Miller ,  Bevin B. McMullin

    IPC分类号： A61M16/12 ,  A61M37/00

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    High-quality twisted-pair transmission line system for high-resolution video
    5.
    发明授权
    High-quality twisted-pair transmission line system for high-resolution video 有权
    高品质双绞线传输线系统，用于高分辨率视频

    公开(公告)号：US07324167B2

    公开(公告)日：2008-01-29

    申请号：US10791636

    申请日：2004-03-02

    申请人： Chris Miller

    发明人： Chris Miller

    IPC分类号： H04N5/00 ,  H04N5/268 ,  H04N17/00 ,  H04N17/173 ,  H04N5/44 ,  H04N17/02 ,  H01P9/00 ,  H04B3/00 ,  H04B3/14 ,  H04L25/00 ,  H04L25/03

    CPC分类号： H04N7/108 ,  H04M11/066

    摘要： A system comprising a first filter having an input and an output adapted to compensate for the characteristics of a first length of twisted-pair wire is disclosed. A first bypass path has an input and an output for bypassing the first filter. A second filter has an input and an output adapted to compensate for the characteristics of a first length of twisted-pair wire. A second bypass path has an input and an output for bypassing the first filter. A third filter has an input and an output adapted to compensate for the characteristics of a first length of twisted-pair wire. A third bypass path has an input and an output for bypassing the first filter. The three filters can be configured form a signal path or one or more filters removed from the signal path by switching in bypass paths.

    摘要翻译： 公开了一种包括具有输入和输出的第一滤波器的系统，其适于补偿第一长度的双绞线的特性。 第一旁路路径具有用于绕过第一滤波器的输入和输出。 第二滤波器具有适于补偿第一长度的双绞线的特性的输入和输出。 第二旁路路径具有用于旁路第一滤波器的输入和输出。 第三滤波器具有适于补偿第一长度的双绞线的特性的输入和输出。 第三个旁路路径具有用于旁路第一滤波器的输入和输出。 三个滤波器可以通过切换旁路路径从信号路径或从信号路径去除的一个或多个滤波器配置。

    Intermittent dosing of nitric oxide gas
    6.
    发明申请
    Intermittent dosing of nitric oxide gas 有权
    间歇给药一氧化氮气体

    公开(公告)号：US20070144515A1

    公开(公告)日：2007-06-28

    申请号：US11598221

    申请日：2006-11-10

    申请人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    发明人： Alex Stenzler ,  Chris Miller ,  Bevin McMullin

    IPC分类号： A61M15/00 ,  A61M16/00

    CPC分类号： A61M16/122 ,  A61H33/14 ,  A61K33/00 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/024 ,  A61M16/04 ,  A61M16/0666 ,  A61M16/0833 ,  A61M16/12 ,  A61M16/201 ,  A61M16/202 ,  A61M16/204 ,  A61M2016/003 ,  A61M2016/102 ,  A61M2202/0275 ,  A61M2205/3327 ,  A61M2205/3334

    摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.

    摘要翻译： 描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。 高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。 该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。 在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

    Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms
    10.
    发明申请
    Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms 有权
    使用外源性一氧化氮在生物膜的处理和消毒中

    公开(公告)号：US20080233212A9

    公开(公告)日：2008-09-25

    申请号：US10953827

    申请日：2004-09-29

    申请人： Chris Miller ,  Abdi Ghaffari ,  Ali Ardakani ,  Bruce Murray ,  Doug Hole

    发明人： Chris Miller ,  Abdi Ghaffari ,  Ali Ardakani ,  Bruce Murray ,  Doug Hole

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00

    摘要： The administration of gaseous nitric oxide as a biocidal moiety is proffered as a de novo treatment in the control and eradication of biofilms. The present invention relates to the use or methods of application of exogenous nitric oxide gas (gNO) as a stand alone biocidal agent or in cohort with any or all adjunct vehicles in the control of biofilms generated by microbial organisms, i.e., bacteria, protozoa, amoeba, fungi etc. Further, the present invention introduces the concept of utilization and methods of application of gaseous nitric oxide in control and eradication of biofilm forming microorganisms. Noteworthy areas of application are offered as examples. They include, and are not limited to, air and/or water heating/cooling distribution systems in facilities such as hospitals and laboratories, surfaces of medical devices, household surfaces, dental plaque, dental and/or medical water treatment lines, industrial pipelines, water treatment and distribution facilities and fluids sterilization. Various specialized delivery apparatus will be designed to facilitate nitric oxide gas administration to each specific unique application.

    摘要翻译： 作为杀生物部分的气态一氧化氮的施用作为在控制和根除生物膜中的从头处理提供。 本发明涉及外源一氧化氮气体（gNO）作为独立杀生物剂或与任何或所有辅助载体一起应用于控制微生物生物体生物膜（即细菌，原生动物， 变形虫，真菌等。此外，本发明介绍了气体一氧化氮在控制和根除生物膜形成微生物中的应用概念和应用方法。 值得注意的应用领域为例。 它们包括但不限于医院和实验室等设施中的空气和/或水加热/制冷分配系统，医疗器械表面，家庭表面，牙菌斑，牙科和/或医疗水处理线，工业管道， 水处理和分配设施和流体灭菌。 将设计各种专门的输送装置，以便于每个特定独特应用的一氧化氮气体管理。