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    Antisense modulation of BCAS1 expression
    7.
    发明授权
    Antisense modulation of BCAS1 expression 有权
    BCAS1表达的反义调制

    公开(公告)号：US06395544B1

    公开(公告)日：2002-05-28

    申请号：US09689255

    申请日：2000-10-11

    申请人： Lex M. Cowsert ,  Susan M. Freier

    发明人： Lex M. Cowsert ,  Susan M. Freier

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K48/00 ,  Y02P20/582

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of BCAS1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BCAS1. Methods of using these compounds for modulation of BCAS1 expression and for treatment of diseases associated with expression of BCAS1 are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节BCAS1的表达。 组合物包含靶向编码BCAS1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节BCAS1表达和治疗与BCAS1表达相关疾病的方法。

    System of components for preparing oligonucleotides
    8.
    发明授权
    System of components for preparing oligonucleotides 失效
    制备寡核苷酸的组分体系

    公开(公告)号：US07321828B2

    公开(公告)日：2008-01-22

    申请号：US09067638

    申请日：1998-04-28

    申请人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    发明人： Lex M. Cowsert ,  Brenda F. Baker ,  John McNeil ,  Susan M. Freier ,  Henri M. Sasmor ,  Douglas G. Brooks ,  Cara Ohashi ,  Jacqueline R. Wyatt ,  Alexander H. Borchers ,  Timothy A. Vickers

    IPC分类号： C12P19/34 ,  G06F19/00 ,  C12Q1/68

    CPC分类号： C12Q1/6811 ,  B01J2219/007 ,  C12N15/1048 ,  C40B50/02 ,  G06F19/18 ,  G06F19/22

    摘要： Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.

    摘要翻译： 提供了用于产生具有期望的物理，化学和/或生物活性的合成化合物（即活性化合物）的相互优选的基于计算机的迭代方法。 在该过程的迭代过程中，提供或选择靶核酸序列，并且根据确定的标准以计算机生成候选核碱基序列的文库。 选择“虚拟”寡核苷酸化学，并产生具有选定的核碱基序列的虚拟寡核苷酸化合物文库。 审查这些虚拟化合物，并选择预测具有特定性质的化合物。 所选择的化合物是机械合成的，并且优选机械地测定所需的物理，化学或生物活性。 因此产生活性化合物，并且同时确定适用于寡核苷酸或基于序列的调节的靶核酸的优选序列和区域。