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公开(公告)号：US20110171730A1
公开(公告)日：2011-07-14
申请号：US12974694
申请日：2010-12-21
IPC分类号： C12N5/071
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2320/11 , C12N2320/32 , C12Y301/03048 , C12N2310/3521 , C12N2310/3525
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US07884086B2
公开(公告)日：2011-02-08
申请号：US11221001
申请日：2005-09-07
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2320/11 , C12N2320/32 , C12Y301/03048 , C12N2310/3521 , C12N2310/3525
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US20050221275A1
公开(公告)日：2005-10-06
申请号：US10824690
申请日：2004-04-14
申请人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi
发明人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi
CPC分类号： C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12Y301/03048 , G01N33/5008 , C12N2310/3525 , C12N2310/3521
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US20060084094A1
公开(公告)日：2006-04-20
申请号：US11221001
申请日：2005-09-07
申请人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi , Richard Griffey , Balkrishen Bhat , Eric Swayze
发明人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi , Richard Griffey , Balkrishen Bhat , Eric Swayze
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2320/11 , C12N2320/32 , C12Y301/03048 , C12N2310/3521 , C12N2310/3525
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US20050260755A1
公开(公告)日：2005-11-24
申请号：US11101017
申请日：2005-04-06
申请人： Brenda Baker , Bryan Kraynack , Namir Sioufi
发明人： Brenda Baker , Bryan Kraynack , Namir Sioufi
CPC分类号： C12Y301/03048 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/30 , C12N2310/3521
摘要： The present invention provides double stranded compositions that have a region that is complementary to a target nucleic acid. The targeting strand comprises linked ribofuranosyl nucleosides and the second strand comprises linked modified nucleosides that have 3′-endo conformational geometry. The strands can be linked together or separate and may contain additional groups. The present invention also provides methods of using the compositions for modulating gene expression.
摘要翻译： 本发明提供具有与靶核酸互补的区域的双链组合物。 靶向链包含连接的呋喃核糖核苷，第二链包含具有3'端构象几何形状的连接的修饰核苷。 链可以连接在一起或分离，并且可以含有另外的基团。 本发明还提供使用该组合物调节基因表达的方法。
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公开(公告)号：US20070238681A1
公开(公告)日：2007-10-11
申请号：US11608160
申请日：2006-12-07
申请人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
发明人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
IPC分类号： A61K31/712 , C07H21/02 , C07H21/04 , C12N15/87
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/15001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。
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公开(公告)号：US20070185044A1
公开(公告)日：2007-08-09
申请号：US10592435
申请日：2005-03-08
申请人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
发明人： Kenneth Dobie , Susan Freier , Michael Buchmeier , Benjamin Neuman , C. Bennett , Namir Sioufi
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/15001 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节ACE2的表达。 组合物包含针对编码ACE2的核酸的寡核苷酸。 提供了使用这些化合物调节ACE2表达和诊断和治疗与ACE2表达相关的疾病和病症的方法。
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