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公开(公告)号：US20050221275A1
公开(公告)日：2005-10-06
申请号：US10824690
申请日：2004-04-14
申请人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi
发明人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi
CPC分类号： C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12Y301/03048 , G01N33/5008 , C12N2310/3525 , C12N2310/3521
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US20060084094A1
公开(公告)日：2006-04-20
申请号：US11221001
申请日：2005-09-07
申请人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi , Richard Griffey , Balkrishen Bhat , Eric Swayze
发明人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker , Namir Sioufi , Richard Griffey , Balkrishen Bhat , Eric Swayze
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2320/11 , C12N2320/32 , C12Y301/03048 , C12N2310/3521 , C12N2310/3525
摘要： The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
摘要翻译： 本发明提供了鉴定体内具有生物活性的寡聚化合物如siRNA和双链RNA化合物的方法以及试剂盒。
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公开(公告)号：US20060160758A1
公开(公告)日：2006-07-20
申请号：US11039632
申请日：2005-01-20
申请人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
发明人： C. Bennett , Susan Freier , Brenda Baker , Brett Monia , Nicholas Dean , Hong Zhang , Susan Murray , Lex Cowsert , Madeline Butler , Robert McKay , Donna Ward , William Gaarde , Ian Popoff , Jacqueline Wyatt , Andrew Watt
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD40 ligand. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD40 ligand. Methods of using these compounds for modulation of CD40 ligand expression and for treatment of diseases associated with expression of CD40 ligand are provided.
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4.发明申请Antisense modulation of sterol regulatory element-binding protein-1 expression 审中-公开固醇调节元件结合蛋白-1表达的反义调制公开(公告)号：US20050215504A1
公开(公告)日：2005-09-29
申请号：US11014360
申请日：2004-12-16
申请人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
发明人： C. Bennett , Susan Freier , Nicholas Dean , Brett Monia , William Gaarde , James Karras , Hong Zhang , Robert McKay , Donna Ward , Lex Cowsert , Erich Koller , Jacqueline Wyatt , Mark Roach , Andrew Watt , Brenda Baker , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sterol regulatory element-binding protein-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sterol regulatory element-binding protein-1. Methods of using these compounds for modulation of sterol regulatory element-binding protein-1 expression and for treatment of diseases associated with expression of sterol regulatory element-binding protein-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节甾醇调节元件结合蛋白-1的表达。 组合物包含靶向编码固醇调节元件结合蛋白-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节固醇调节元件结合蛋白-1表达和治疗与甾醇调节元件结合蛋白-1的表达相关的疾病的方法。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20050164209A1
公开(公告)日：2005-07-28
申请号：US10763367
申请日：2004-01-23
申请人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker
发明人： C. Bennett , Robert McKay , Brett Monia , Brenda Baker
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12Y301/03048 , C12N2310/3525 , C12N2310/3521
摘要： The present invention provides methods of identifying an oligomeric compound having bioactivity in vivo, methods of identifying a small interfering RNA having bioactivity in vivo, and kits.
摘要翻译： 本发明提供鉴定体内具有生物活性的寡聚化合物的方法，鉴定体内具有生物活性的小干扰RNA的方法和试剂盒。
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7.发明申请Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry 审中-公开包括北部和南部构象几何的交替区域的嵌合寡聚化合物公开(公告)号：US20050074801A1
公开(公告)日：2005-04-07
申请号：US10936273
申请日：2004-09-08
申请人： Brett Monia , Madeline Butler , Robert McKay , Brenda Baker
发明人： Brett Monia , Madeline Butler , Robert McKay , Brenda Baker
IPC分类号： C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C07H21/00 , C12N15/111 , C12N2310/32 , C12N2310/321 , C12N2310/323 , C12N2310/3231 , C12N2320/51
摘要： The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3′-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.
摘要翻译： 本发明涉及具有多个交替区域的新型嵌合寡聚化合物，所述交替区域具有如具有北或3'-端构象几何（3'-末端区域）的RNA或具有南部或C2'端/ O4'端 构象几何。 本发明的寡聚化合物已显示多个体外和体内测定系统中mRNA水平的降低，并且例如用于调查和治疗目的是有用的。
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公开(公告)号：US20050267063A1
公开(公告)日：2005-12-01
申请号：US11117013
申请日：2005-04-27
申请人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Susan Freier , Brenda Baker , William Gaarde , Erich Koller , Susan Murray , Andrew Watt , Jacqueline Wyatt , Pamela Nero , Mark Roach , Lex Cowsert , Kenneth Dobie
CPC分类号： C12N15/1137 , A61K38/00 , B23Q2011/0808 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of p70 S6 kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding p70 S6 kinase. Methods of using these compounds for modulation of p70 S6 kinase expression and for treatment of diseases associated with expression of p70 S6 kinase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节p70 S6激酶的表达。 组合物包含靶向编码p70 S6激酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节p70 S6激酶表达和治疗与p70 S6激酶表达相关的疾病的方法。
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公开(公告)号：US20050153925A1
公开(公告)日：2005-07-14
申请号：US11013608
申请日：2004-12-16
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Brenda Baker , Donna Ward , William Gaarde , Lex Cowsert , Andrew Watt , Kenneth Dobie
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of hepatocyte growth factor receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hepatocyte growth factor receptor. Methods of using these compounds for modulation of hepatocyte growth factor receptor expression and for diagnosis and treatment of disease associated with expression of hepatocyte growth factor receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节肝细胞生长因子受体的表达。 组合物包含针对编码肝细胞生长因子受体的核酸的寡核苷酸。 提供了使用这些化合物调节肝细胞生长因子受体表达和用于诊断和治疗与肝细胞生长因子受体表达相关的疾病的方法。
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公开(公告)号：US20050153924A1
公开(公告)日：2005-07-14
申请号：US11013543
申请日：2004-12-15
申请人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
发明人： C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。
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