公开(公告)号：US20240239799A1

公开(公告)日：2024-07-18

申请号：US18553597

申请日：2022-04-01

申请人： C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING ,  IRBM S.p.A.

发明人： Romano DI FABIO ,  Christian MONTALBETTI ,  Alessia PETROCCHI ,  Alessandro GRILLO ,  Pietro RANDAZZO ,  Ilaria ROSSETTI ,  Alina CIAMMAICHELLA

IPC分类号： C07D471/20 ,  A61K31/497 ,  A61K45/06

CPC分类号： C07D471/20 ,  A61K31/497 ,  A61K45/06

摘要： The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

公开(公告)号：US20240109900A1

公开(公告)日：2024-04-04

申请号：US18264299

申请日：2022-02-08

申请人： IRBM S.P.A. ,  C.N.C.C.S. S.C.A.R.L. COLLEZIONE NAZIONALE DEI COMPOSTI CHIMICI E CENTRO SCREENING

发明人： Alina CIAMMAICHELLA ,  Romano DI FABIO ,  Federica FERRIGNO ,  Paola FEZZARDI ,  Christian MONTALBETTI ,  Alessia PETROCCHI ,  Nicola RELITTI ,  Ilaria ROSSETTI ,  Alessio SFERRAZZA ,  Esther TORRENTE ,  Luca FERRANTE ,  Alessandro GRILLO

IPC分类号： C07D487/04 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).

公开(公告)号：US20220241241A1

公开(公告)日：2022-08-04

申请号：US17611777

申请日：2020-05-25

申请人： ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM ,  OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A.

发明人： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Leda IVANOVA BENCHEVA ,  Marilenia DE MATTEO ,  Luca FERRANTE ,  Davide GORNATI ,  Alessandro GRILLO

IPC分类号： A61K31/407 ,  C07D515/14 ,  C07D513/14 ,  A61P31/20 ,  A61K39/395 ,  A61K38/21 ,  A61K31/522 ,  A61K31/513 ,  A61K31/7072 ,  A61K31/675 ,  A61K31/437 ,  A61K31/7084 ,  A61K31/506 ,  A61K31/445 ,  A61K39/29

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.

公开(公告)号：US20210276967A1

公开(公告)日：2021-09-09

申请号：US17261223

申请日：2019-07-19

申请人： OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM

发明人： Raffaele DE FRANCESCO ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Luca FERRANTE

IPC分类号： C07D305/08 ,  A61K45/06 ,  C07D207/48 ,  C07D213/42 ,  C07D205/04 ,  C07D213/73 ,  C07D211/96 ,  C07C311/16

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

公开(公告)号：US20220110943A1

公开(公告)日：2022-04-14

申请号：US17267693

申请日：2019-08-09

申请人： OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE Dl GENETICA MOLECOLARE - INGM

发明人： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Davide GORNATI ,  Alessandro GRILLO ,  Luca FERRANTE ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Marco FERRARA

IPC分类号： A61K31/554 ,  C07D515/14 ,  C07D515/08 ,  A61K31/407 ,  C07D519/00 ,  C07D513/14 ,  A61P31/20

摘要： The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.