公开(公告)号：US11446523B2

公开(公告)日：2022-09-20

申请号：US16833637

申请日：2020-03-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

公开(公告)号：US11944848B2

公开(公告)日：2024-04-02

申请号：US17816373

申请日：2022-07-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

公开(公告)号：US12109440B2

公开(公告)日：2024-10-08

申请号：US17816373

申请日：2022-07-29

Applicant: California Institute of Technology

Inventor： Avinoam D. Bar-Zion ,  Atousa Nourmahnad ,  David Maresca ,  Mikhail Shapiro

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0082

Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

公开(公告)号：US11786218B2

公开(公告)日：2023-10-17

申请号：US16736581

申请日：2020-01-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Daniel P. Sawyer ,  Arash Farhadi ,  Avinoam D. Bar-Zion ,  Mikhail Shapiro

IPC: A61B8/08

CPC classification number: A61B8/5207 ,  A61B8/481 ,  A61B8/5246

Abstract: The application of a step function increase in acoustic pressure during ultrasound imaging using gas vesicle contrast, along with capturing successive frames of ultrasound imaging and extracting time-series vectors for pixels of the frames, allows for improved imaging down to even the cell level. Template vectors can be used to implement signal separation of the time-series vectors to improve detection.

公开(公告)号：US11653899B2

公开(公告)日：2023-05-23

申请号：US16736581

申请日：2020-01-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Daniel P. Sawyer ,  Arash Farhadi ,  Avinoam D. Bar-Zion ,  Mikhail Shapiro

IPC: A61B8/08

CPC classification number: A61B8/5207 ,  A61B8/481 ,  A61B8/5246

Abstract: The application of a step function increase in acoustic pressure during ultrasound imaging using gas vesicle contrast, along with capturing successive frames of ultrasound imaging and extracting time-series vectors for pixels of the frames, allows for improved imaging down to even the cell level. Template vectors can be used to implement signal separation of the time-series vectors to improve detection.