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1.发明授权公开(公告)号：US11504438B2
公开(公告)日：2022-11-22
申请号：US16656417
申请日：2019-10-17
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Anupama Lakshmanan , Arash Farhadi , Suchita P. Nety , Raymond W. Bourdeau , Mikhail Shapiro
IPC: A61K49/22 , C07K14/195 , A61K49/00 , A61B8/08
Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
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公开(公告)号：US20210141034A1
公开(公告)日：2021-05-13
申请号：US17097349
申请日：2020-11-13
Applicant: California Institute of Technology
Inventor： Saransh Sharma , Mikhail Shapiro , Azita Emami
IPC: G01R33/022 , G01B7/31 , G01R33/385
Abstract: An apparatus for producing magnetic field gradients includes (a) a first planar electromagnet coil set configured to produce a first magnetic field gradient with respect to a first axis, (b) a second planar electromagnet coil set configured to produce a second magnetic field gradient with respect to a second axis that is orthogonal to the first axis, (c) a third planar electromagnet coil set configured to produce a third magnetic field gradient with respect to a third axis that is orthogonal to the first and second axes, and (d) a controller configured to selectively provide power to the first, second, and/or third electromagnet coil sets to sequentially produce a localization magnetic field gradient with respect to each of the first, second, and third axes, at least a portion of each localization magnetic field gradient having a monotonically-varying magnetic field magnitude along a respective axis.
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公开(公告)号：US20190314001A1
公开(公告)日：2019-10-17
申请号：US16387259
申请日：2019-04-17
Applicant: California Institute of Technology
Inventor： David Maresca , Daniel P. Sawyer , Mikhail Shapiro
Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems.
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公开(公告)号：US12241069B2
公开(公告)日：2025-03-04
申请号：US18317915
申请日：2023-05-15
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Arash Farhadi , Gabrielle H Ho , Daniel P Sawyer , Mikhail Shapiro , Robert C. Hurt , Mengtong Duan
IPC: C12N15/67 , C07K14/195
Abstract: Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
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公开(公告)号：US11944848B2
公开(公告)日：2024-04-02
申请号：US17816373
申请日：2022-07-29
Applicant: California Institute of Technology
Inventor： Avinoam D. Bar-Zion , Atousa Nourmahnad , David Maresca , Mikhail Shapiro
IPC: A61N7/00
CPC classification number: A61N7/00 , A61N2007/0004 , A61N2007/0039 , A61N2007/0052 , A61N2007/0082
Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
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Patent Agency Ranking
公开(公告)号：US11649462B2
公开(公告)日：2023-05-16
申请号：US16736683
申请日：2020-01-07
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Arash Farhadi , Gabrielle H Ho , Daniel P Sawyer , Mikhail Shapiro , Robert C. Hurt , Mengtong Duan
IPC: C12N15/67 , C07K14/195
CPC classification number: C12N15/67 , C07K14/195 , C12N2510/02
Abstract: Provided herein are genetically engineered gas vesicle expression systems (GVES) that are configured to express gas vesicles (GVs) in a mammalian cell, related gas vesicle polynucleotide constructs, gas vesicle reporting genetic circuits, vectors, genetically engineered mammalian cells, non-human mammalian hosts, compositions, methods and systems, which in several embodiments can be used together with contrast-enhanced imaging techniques to detect and report biological events in an imaging target site comprising a mammalian cell and/or organism.
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公开(公告)号：US11446523B2
公开(公告)日：2022-09-20
申请号：US16833637
申请日：2020-03-29
Applicant: California Institute of Technology
Inventor： Avinoam D. Bar-Zion , Atousa Nourmahnad , David Maresca , Mikhail Shapiro
IPC: A61N7/00
Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
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公开(公告)号：US11350909B2
公开(公告)日：2022-06-07
申请号：US16387259
申请日：2019-04-17
Applicant: California Institute of Technology
Inventor： David Maresca , Daniel P. Sawyer , Mikhail Shapiro
Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.
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9.发明申请公开(公告)号：US20210138066A1
公开(公告)日：2021-05-13
申请号：US17092215
申请日：2020-11-07
Applicant: California Institute of Technology
Inventor： Maria Paulene B. Abundo , Mikhail Shapiro
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in the spatial and temporal delivery of payload molecules to a target site of a subject. Disclosed herein include hydrogel compositions (e.g., particles) comprising a polymer scaffold, a plurality of payload molecules, and a plurality of gas vesicles. The method can comprise administering said hydrogel compositions to a subject and applying one or more ultrasonic (US) pulses to a target site of the subject to induce the release of payload molecules from the hydrogel composition, thereby delivering payload molecules to the target site. The method can comprise detecting the presence of the hydrogel composition at the target site prior to inducing release of payload molecules from the hydrogel composition.
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10.发明授权公开(公告)号：US10466227B2
公开(公告)日：2019-11-05
申请号：US15882281
申请日：2018-01-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Mikhail Shapiro , Azita Emami , Manuel Alejandro Monge Osorio
IPC: G01N33/46 , G01R17/00 , G01R33/07 , A61B5/00 , A61B5/04 , A61B5/07 , A61B5/1459 , G01N33/483 , H04B1/40 , G01R33/12 , A61B5/05
Abstract: Methods and apparatuses for sensing biological functions are disclosed. Sensors can be implanted in an organ, such as the brain, and a magnetic field gradient applied to the biological tissue. The field causes the sensors to have different resonant frequencies allowing their spatial localization. The sensors can harvest power from the external coils to be able to retransmit data.
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