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Patent Agency Ranking
1.发明授权Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface 有权由具有从器件表面突出的对准的碳纳米管的纳米增强器件促进药物递送和物质转移公开(公告)号：US09050444B2
公开(公告)日：2015-06-09
申请号：US13762197
申请日：2013-02-07
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Adrianus I. Aria , Elijah Bodhi Sansom
IPC: A61M5/00 , A61M37/00 , A61K47/48 , A61L27/44 , A61L27/54 , A61L27/56 , B29C70/64 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B31/02 , A61B5/145 , A61M5/44 , A61M25/10 , A61N1/30 , A61N5/06 , B29K105/16
CPC classification number: A61M37/0015 , A61B5/14532 , A61K47/6957 , A61L27/443 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2400/12 , A61M5/44 , A61M25/104 , A61M37/0092 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , A61N1/306 , A61N5/062 , B29C70/64 , B29K2105/162 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15
Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.
Abstract translation: 本发明涉及一种纳米增强器件，用于器件与组织之间的物质转移。 该装置包括基本上对准的碳纳米管的衬底，锚定在衬底内，并且碳纳米管的至少一端从衬底突出。 突出的纳米管末端可以涂覆有用于将药物递送到身体组织中的药物。 本发明可以并入血管成形术导管球囊或穿在皮肤上的贴剂中。 碳纳米管可以分组成簇以有效地形成可以将流体传送到皮下组织或从皮下组织传递流体的纳米针。 纳米针可与传感器结合使用，以确定体液信息，如pH值，葡萄糖水平等。
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2.发明申请Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface 审中-公开药物递送和物质转移由具有对准碳纳米管的纳米增强器件促进从器件表面突出公开(公告)号：US20130158377A1
公开(公告)日：2013-06-20
申请号：US13762197
申请日：2013-02-07
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Adrianus I. Aria , Elijah Bodhi Sansom
CPC classification number: A61M37/0015 , A61B5/14532 , A61K47/6957 , A61L27/443 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2400/12 , A61M5/44 , A61M25/104 , A61M37/0092 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , A61N1/306 , A61N5/062 , B29C70/64 , B29K2105/162 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15
Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.
Abstract translation: 本发明涉及一种纳米增强器件，用于器件与组织之间的物质转移。 该装置包括基本上对准的碳纳米管的衬底，锚定在衬底内，并且碳纳米管的至少一端从衬底突出。 突出的纳米管末端可以涂覆有用于将药物递送到身体组织中的药物。 本发明可以并入血管成形术导管球囊或穿在皮肤上的贴剂中。 碳纳米管可以分组成簇以有效地形成可以将流体传送到皮下组织或从皮下组织传递流体的纳米针。 纳米针可与传感器结合使用，以确定体液信息，如pH值，葡萄糖水平等。
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3.发明申请DRUG DELIVERY AND SUBSTANCE TRANSFER FACILITATED BY NANO-ENHANCED DEVICE HAVING ALIGNED CARBON NANOTUBES PROTRUDING FROM DEVICE SURFACE 审中-公开由装置表面涂覆的对准碳纳米管的纳米增强器件使用的药物递送和物质转移公开(公告)号：US20150238742A1
公开(公告)日：2015-08-27
申请号：US14708694
申请日：2015-05-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Adrianus I. Aria , Elijah Bodhi Sansom
IPC: A61M37/00
CPC classification number: A61M37/0015 , A61B5/14532 , A61K47/6957 , A61L27/443 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2400/12 , A61M5/44 , A61M25/104 , A61M37/0092 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , A61N1/306 , A61N5/062 , B29C70/64 , B29K2105/162 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15
Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.
Abstract translation: 本发明涉及一种纳米增强器件，用于器件与组织之间的物质转移。 该装置包括基本上对准的碳纳米管的衬底，锚定在衬底内，并且碳纳米管的至少一端从衬底突出。 突出的纳米管末端可以涂覆有用于将药物递送到身体组织中的药物。 本发明可以并入血管成形术导管球囊或穿在皮肤上的贴剂中。 碳纳米管可以分组成簇以有效地形成可以将流体传送到皮下组织或从皮下组织传递流体的纳米针。 纳米针可与传感器结合使用，以确定体液信息，如pH值，葡萄糖水平等。
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4.发明申请METHOD FOR SELECTIVELY ANCHORING AND EXPOSING LARGE NUMBERS OF NANOSCALE STRUCTURES 审中-公开选择性地扩大和扩大纳米结构数量的方法公开(公告)号：US20150064396A1
公开(公告)日：2015-03-05
申请号：US14484030
申请日：2014-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Elijah Bodhi Sansom , Derek Rinderknecht , Morteza Gharib
CPC classification number: B32B37/025 , A61M37/0015 , B01D46/546 , B08B17/065 , B29C70/64 , B29K2105/162 , B32B37/06 , B32B37/12 , B32B2037/1253 , B32B2305/72 , B32B2310/0806 , B32B2313/04 , B32B2398/20 , B63B1/32 , B82B3/0014 , B82B3/0047 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B32/18 , C01B2202/08 , F28F13/185 , Y10S977/742 , Y10S977/753 , Y10T428/23979 , Y10T428/24273 , Y10T428/249924
Abstract: Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an anchoring substrate. Nanostructures are provided on an initial substrate, the nanostructures having a defined height and orientation with respect to the initial substrate. The nanostructures are introduced to a desired depth in the primary fluid layer, such that the orientation of the nanostructures relative to the growth substrate is substantially maintained. The primary fluid layer comprises one or more fluid layers. Ones of multiple fluid layers are selected such that when altered to form an anchoring structure, a portion of the anchoring structure can be removed, permitting exposure of at least a portion of the nanostructures from the anchoring structure in which they are affixed. The growth substrate is removed. Ends or other parts of nanostructures may be exposed from the anchoring structure.
Abstract translation: 将纳米尺度结构固定在锚固结构内以形成由其形成的纳米结构复合材料和纳米结构复合材料的方法。 主要流体层形成在锚固衬底上。 纳米结构提供在初始基底上，纳米结构相对于初始底物具有限定的高度和取向。 将纳米结构引入初级流体层中所需的深度，使得纳米结构相对于生长衬底的取向基本上保持。 主流体层包括一个或多个流体层。 选择多个流体层的一部分，使得当改变以形成锚定结构时，可以去除锚定结构的一部分，允许至少一部分纳米结构从其所固定的锚定结构暴露。 除去生长底物。 纳米结构的末端或其他部分可能从锚定结构暴露出来。
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公开(公告)号：US09352136B2
公开(公告)日：2016-05-31
申请号：US14708694
申请日：2015-05-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Adrianus I. Aria , Elijah Bodhi Sansom
IPC: A61M37/00 , A61K47/48 , A61L27/44 , A61L27/54 , A61L27/56 , B29C70/64 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B31/02 , A61B5/145 , A61M5/44 , A61M25/10 , A61N1/30 , A61N5/06 , B29K105/16
CPC classification number: A61M37/0015 , A61B5/14532 , A61K47/6957 , A61L27/443 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2400/12 , A61M5/44 , A61M25/104 , A61M37/0092 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061 , A61N1/306 , A61N5/062 , B29C70/64 , B29K2105/162 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15
Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.
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