公开(公告)号：US20170189530A1

公开(公告)日：2017-07-06

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark Thompson ,  Oliver Shafaat ,  Erin Lamb

IPC: A61K41/00 ,  A61F9/007 ,  A61N5/06

CPC classification number: A61K41/0057 ,  A61F9/0079 ,  A61K41/00 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0626 ,  A61N2005/0648

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

公开(公告)号：US10035806B2

公开(公告)日：2018-07-31

申请号：US15286983

申请日：2016-10-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Harry B. Gray ,  Robert H. Grubbs ,  Joshua Palmer

IPC: C07D487/22 ,  A61K31/409 ,  C07F5/00

CPC classification number: C07D487/22 ,  C07F5/003

Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.

公开(公告)号：US10406227B2

公开(公告)日：2019-09-10

申请号：US14650208

申请日：2013-12-18

Applicant: University of Southern California ,  California Institute of Technology

Inventor： Robert H. Chow ,  Mark S. Humayun ,  Harry B. Gray ,  Robert H. Grubbs ,  Dennis A. Dougherty ,  Mark E. Thompson ,  Lionel E. Cheruzel ,  Melanie A. Yen

IPC: A61K41/00 ,  C12N13/00 ,  A61N5/06 ,  A61B3/113

Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

公开(公告)号：US10232043B2

公开(公告)日：2019-03-19

申请号：US15240997

申请日：2016-08-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Dennis A. Dougherty ,  Robert H. Grubbs ,  Harry B. Gray ,  Robert H. Chow ,  Mark S. Humayun ,  Mark E. Thompson ,  Lionel E. Cheruzel

IPC: C12N13/00 ,  A61K41/00 ,  A61N5/06 ,  A61F9/007

Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.