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公开(公告)号：US10406227B2
公开(公告)日：2019-09-10
申请号：US14650208
申请日：2013-12-18
Inventor： Robert H. Chow , Mark S. Humayun , Harry B. Gray , Robert H. Grubbs , Dennis A. Dougherty , Mark E. Thompson , Lionel E. Cheruzel , Melanie A. Yen
Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
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公开(公告)号：US10232043B2
公开(公告)日：2019-03-19
申请号：US15240997
申请日：2016-08-18
Inventor： Melanie A. Yen , Dennis A. Dougherty , Robert H. Grubbs , Harry B. Gray , Robert H. Chow , Mark S. Humayun , Mark E. Thompson , Lionel E. Cheruzel
Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
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公开(公告)号：US09580451B2
公开(公告)日：2017-02-28
申请号：US14604917
申请日：2015-01-26
Inventor： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC: C07F7/28 , C07D487/22 , C07F5/00 , C07F5/06 , A61K49/00
CPC classification number: C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：
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公开(公告)号：US11352705B2
公开(公告)日：2022-06-07
申请号：US15675065
申请日：2017-08-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Bryan M. Hunter , Harry B. Gray
IPC: C25B3/07 , C25B3/23 , C25B11/091 , C25B11/051 , C25B11/057
Abstract: Processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product may include: contacting a water oxidation electrocatalyst with the hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to the water oxidation electrocatalyst, thereby generating the oxidized hydrocarbon product; and wherein the water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, the water is provided in the non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of the anodic bias is selected to generate the oxidized hydrocarbon product characterized by selected product distribution.
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公开(公告)号：US09243015B2
公开(公告)日：2016-01-26
申请号：US14177064
申请日：2014-02-10
Applicant: California Institute of Technology
Inventor： Joshua H. Palmer , Zeev Gross , Harry B. Gray
IPC: C07D487/22 , C07F15/00
CPC classification number: C07F15/0033 , C07F15/0053 , C07F15/0093
Abstract: Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.
Abstract translation: 可以使用第三排过渡金属的金属络合物（参见下面的式I）作为治疗剂，催化剂，氧检测器的组分和发光二极管的组分。 特别地，第三排过渡金属的金属络合物可用作光动力疗法中的改进的光敏剂; 作为氮丙啶化，环氧化和水分解反应中改进的催化剂; 作为改进的体内成像剂; 并且作为OLED的发射层中的改进的组分。 由于它们具有强烈的西格玛特性，因此腐蚀能够稳定高氧化态的第三排过渡金属。 第三排过渡金属比其第一和第二排对应物显着更多的正电性，因此可以用作改进的催化剂。 此外，第三行过渡金属的高自旋轨道耦合常数可能导致在激发态下更容易的单线 - 三线态跨系统交叉，这又可能允许对于许多应用是期望的长波长磷光。
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Patent Agency Ranking
公开(公告)号：US20140227187A1
公开(公告)日：2014-08-14
申请号：US14178592
申请日：2014-02-12
Inventor： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
CPC classification number: C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：
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公开(公告)号：US20140179918A1
公开(公告)日：2014-06-26
申请号：US14177064
申请日：2014-02-10
Applicant: California Institute of Technology
Inventor： Joshua H. Palmer , Zeev Gross , Harry B. Gray
IPC: C07F15/00
CPC classification number: C07F15/0033 , C07F15/0053 , C07F15/0093
Abstract: Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.
Abstract translation: 可以使用第三排过渡金属的金属络合物（参见下面的式I）作为治疗剂，催化剂，氧检测器的组分和发光二极管的组分。 特别地，第三排过渡金属的金属络合物可用作光动力疗法中的改进的光敏剂; 作为氮丙啶化，环氧化和水分解反应中改进的催化剂; 作为改进的体内成像剂; 并且作为OLED的发射层中的改进的组分。 由于它们具有强烈的西格玛特性，因此腐蚀能够稳定高氧化态的第三排过渡金属。 第三排过渡金属比其第一和第二排对应物显着更多的正电性，因此可以用作改进的催化剂。 此外，第三行过渡金属的高自旋轨道耦合常数可能导致在激发态下更容易的单线 - 三线态跨系统交叉，这又可能允许对于许多应用是期望的长波长磷光。
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公开(公告)号：US20170189530A1
公开(公告)日：2017-07-06
申请号：US15240997
申请日：2016-08-18
Inventor： Melanie A. Yen , Dennis A. Dougherty , Robert H. Grubbs , Harry B. Gray , Robert H. Chow , Mark S. Humayun , Mark Thompson , Oliver Shafaat , Erin Lamb
CPC classification number: A61K41/0057 , A61F9/0079 , A61K41/00 , A61N5/062 , A61N5/0622 , A61N2005/0626 , A61N2005/0648
Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
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公开(公告)号：US20150141640A1
公开(公告)日：2015-05-21
申请号：US14604917
申请日：2015-01-26
Inventor： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC: C07F7/28
CPC classification number: C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：
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公开(公告)号：US20130178360A1
公开(公告)日：2013-07-11
申请号：US13734088
申请日：2013-01-04
Applicant: California Institute of Technology
Inventor： Nathan S. Lewis , James R. McKone , Harry B. Gray
CPC classification number: H01M4/9091 , C01B3/42 , C10G45/08 , H01M4/8825 , H01M4/9041
Abstract: The disclosure provides methods and compositions comprising metal alloy powders. The disclosure also provides a photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material.
Abstract translation: 本公开提供了包含金属合金粉末的方法和组合物。 本公开还提供了一种光电极，其制造和使用方法，包括用于水分解的系统。 该光电极可以是具有涂覆在该材料上的诸如镍或镍 - 钼的光催化剂的半导体材料。
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