公开(公告)号：US20230286906A1

公开(公告)日：2023-09-14

申请号：US17780052

申请日：2020-11-25

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  AZADEH PIRI SEDIGH ,  QUANG HUY TO

IPC分类号： C07C233/65 ,  C07C259/10 ,  C07C233/92 ,  C07D213/40 ,  C07D239/26 ,  C07D261/14 ,  C07D263/32 ,  C07D271/06 ,  C07D257/04 ,  C07C233/83 ,  C07D233/64 ,  C07D487/04 ,  C07D295/192 ,  C07D295/26 ,  C07D295/24 ,  C07D207/16 ,  C07D207/12 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/00 ,  C07C233/78 ,  C07C233/69 ,  C07C233/66

CPC分类号： C07C233/65 ,  C07C259/10 ,  C07C233/92 ,  C07D213/40 ,  C07D239/26 ,  C07D261/14 ,  C07D263/32 ,  C07D271/06 ,  C07D257/04 ,  C07C233/83 ,  C07D233/64 ,  C07D487/04 ,  C07D295/192 ,  C07D295/26 ,  C07D295/24 ,  C07D207/16 ,  C07D207/12 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/00 ,  C07C233/78 ,  C07C233/69 ,  C07C233/66 ,  C07C2601/08 ,  C07C2601/02

摘要： This disclosure relates generally to cannabinoid derivatives having the structural formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives. In some embodiments, R1 is —CH2CH═C(CH3)2, R2 is methyl, R3 is CsHn, R4 is —C(O)N(R4a)(R4b), R5 is H, R6 is OH, and R7 is H. Compounds of the present disclosure were tested in agonist and antagonist mode for both the CB1 and CB2 receptors. The tested compounds were generally found to exhibit activity in antagonist mode at the CB1 and CB2 receptor.

公开(公告)号：US20220348586A1

公开(公告)日：2022-11-03

申请号：US17765856

申请日：2020-10-02

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  QUANG HUY TO ,  PETER MARTIN DOVE

IPC分类号： C07D487/04 ,  C07C235/60 ,  C07C235/58 ,  C07C235/88 ,  C07C235/62 ,  C07C235/64 ,  C07D239/26 ,  C07D261/08 ,  C07D263/32 ,  C07D233/64 ,  C07D213/40 ,  C07D257/04 ,  C07D295/192 ,  C07D295/26 ,  C07D207/16 ,  C07D207/24 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/29 ,  C07C271/16 ,  C07C271/34 ,  C07C271/48 ,  C07C271/24 ,  C07C233/60 ,  C07C233/18 ,  C07D261/14 ,  C07D271/10

摘要： This disclosure relates to cannabinoid derivatives of Formula (I), wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the cannabinoid derivatives. These compounds are potential cannabinoid receptor inhibitors, including CB1 and CB2 receptors.

公开(公告)号：US20220340582A1

公开(公告)日：2022-10-27

申请号：US17765853

申请日：2020-10-02

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  QUANG HUY TO

IPC分类号： C07D487/04 ,  C07D311/80 ,  C07D405/12 ,  C07D413/12

摘要： This disclosure relates generally to cannabinoid derivatives having the formula (I), wherein R4 is hydrogen, —C(Q1)N(R4a)(R4b) or —C(R4J)(R4k)N(R4e)C(0)R4f, R6 is hydrogen, —C(Q2)N(R6a)(R6b) or —C(R6J)(R6k)N(R6e)C(0)R6f, provided that R6 is not hydrogen when R4 is hydrogen. Pharmaceutical compositions for the prevention or treatment of a disease associated with a cannabinoid receptor (such as CB1 or CB2) in a subject in need thereof, and methods of using the cannabinoid derivatives are also described.