公开(公告)号：US20230134776A1

公开(公告)日：2023-05-04

申请号：US17626519

申请日：2020-07-10

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  KRISHNA KUMAR GNANASEKARAN ,  JEFFREY ALAN OMEARA ,  JI SUNG PARK

IPC分类号： C07C311/29 ,  C07D295/26 ,  C07C311/51 ,  C07C317/22 ,  C07C69/16 ,  C07D213/71 ,  C07C309/42 ,  C07D307/64 ,  C07D233/84 ,  C07D305/08 ,  C07D207/404 ,  C07D211/54 ,  C07D239/38 ,  C07D205/06 ,  C07D205/12 ,  C07D487/10 ,  C07D249/08 ,  C07D249/10 ,  C07D235/16 ,  C07D277/30 ,  C07D263/32

摘要： This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPARγ or a μ-opioid receptor.

公开(公告)号：US20220242856A1

公开(公告)日：2022-08-04

申请号：US17626512

申请日：2020-07-10

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JEFFREY ALAN OMEARA ,  PETER MARTIN DOVE

IPC分类号： C07D413/04 ,  C07D405/04 ,  C07D409/04 ,  C07D407/04 ,  C07D417/04 ,  C07D473/00

摘要： This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in the treatment or prevention of a disease associated with a cannabinoid receptor, including receptors selected from CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPARγ or a μ-opioid receptor.

公开(公告)号：US20230286906A1

公开(公告)日：2023-09-14

申请号：US17780052

申请日：2020-11-25

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  AZADEH PIRI SEDIGH ,  QUANG HUY TO

IPC分类号： C07C233/65 ,  C07C259/10 ,  C07C233/92 ,  C07D213/40 ,  C07D239/26 ,  C07D261/14 ,  C07D263/32 ,  C07D271/06 ,  C07D257/04 ,  C07C233/83 ,  C07D233/64 ,  C07D487/04 ,  C07D295/192 ,  C07D295/26 ,  C07D295/24 ,  C07D207/16 ,  C07D207/12 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/00 ,  C07C233/78 ,  C07C233/69 ,  C07C233/66

CPC分类号： C07C233/65 ,  C07C259/10 ,  C07C233/92 ,  C07D213/40 ,  C07D239/26 ,  C07D261/14 ,  C07D263/32 ,  C07D271/06 ,  C07D257/04 ,  C07C233/83 ,  C07D233/64 ,  C07D487/04 ,  C07D295/192 ,  C07D295/26 ,  C07D295/24 ,  C07D207/16 ,  C07D207/12 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/00 ,  C07C233/78 ,  C07C233/69 ,  C07C233/66 ,  C07C2601/08 ,  C07C2601/02

摘要： This disclosure relates generally to cannabinoid derivatives having the structural formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives. In some embodiments, R1 is —CH2CH═C(CH3)2, R2 is methyl, R3 is CsHn, R4 is —C(O)N(R4a)(R4b), R5 is H, R6 is OH, and R7 is H. Compounds of the present disclosure were tested in agonist and antagonist mode for both the CB1 and CB2 receptors. The tested compounds were generally found to exhibit activity in antagonist mode at the CB1 and CB2 receptor.

公开(公告)号：US20220324806A1

公开(公告)日：2022-10-13

申请号：US17626516

申请日：2020-07-10

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JEFFREY ALAN OMEARA ,  PETER MARTIN DOVE

IPC分类号： C07D213/30 ,  C07D307/42 ,  C07C39/24 ,  C07D239/26 ,  C07D333/16 ,  C07D231/12 ,  C07D333/56 ,  C07D261/08 ,  C07C255/53 ,  C07D257/04 ,  C07C43/225 ,  C07D295/033 ,  C07C43/205 ,  C07D271/06 ,  C07D271/113 ,  C07D249/08 ,  C07D207/333 ,  C07D277/26 ,  C07D209/12 ,  C07D235/18 ,  C07D473/00 ,  C07D305/06 ,  C07D303/14 ,  C07D203/10 ,  C07D263/14 ,  C07D309/32 ,  C07D241/12

摘要： The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.

公开(公告)号：US20230122510A1

公开(公告)日：2023-04-20

申请号：US17780054

申请日：2020-11-25

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JEFFREY ALAN OMEARA ,  PETER MARTIN DOVE

IPC分类号： C07C35/14

摘要： This disclosure relates generally to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives for the treatment of conditions associated with cannabinoid receptor.

公开(公告)号：US20220348586A1

公开(公告)日：2022-11-03

申请号：US17765856

申请日：2020-10-02

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  QUANG HUY TO ,  PETER MARTIN DOVE

IPC分类号： C07D487/04 ,  C07C235/60 ,  C07C235/58 ,  C07C235/88 ,  C07C235/62 ,  C07C235/64 ,  C07D239/26 ,  C07D261/08 ,  C07D263/32 ,  C07D233/64 ,  C07D213/40 ,  C07D257/04 ,  C07D295/192 ,  C07D295/26 ,  C07D207/16 ,  C07D207/24 ,  C07D209/44 ,  C07D209/08 ,  C07D203/18 ,  C07D205/04 ,  C07C255/29 ,  C07C271/16 ,  C07C271/34 ,  C07C271/48 ,  C07C271/24 ,  C07C233/60 ,  C07C233/18 ,  C07D261/14 ,  C07D271/10

摘要： This disclosure relates to cannabinoid derivatives of Formula (I), wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the cannabinoid derivatives. These compounds are potential cannabinoid receptor inhibitors, including CB1 and CB2 receptors.

公开(公告)号：US20230150927A1

公开(公告)日：2023-05-18

申请号：US17780047

申请日：2020-11-25

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  KRISHNA KUMAR GNANASEKARAN ,  JEFFREY ALAN OMEARA

IPC分类号： C07C311/29 ,  A61P3/00 ,  C07D295/26 ,  C07C311/51 ,  C07D213/71 ,  C07C317/22 ,  C07C309/75 ,  C07D307/64 ,  C07D233/84 ,  C07D305/08 ,  C07D207/408 ,  C07D211/54 ,  C07D239/40 ,  C07D205/06 ,  C07D205/12 ,  C07D487/10 ,  C07D295/15 ,  C07D249/08 ,  C07D249/10 ,  C07D263/32 ,  C07D277/30 ,  C07D235/16 ,  C07D235/28

CPC分类号： C07C311/29 ,  A61P3/00 ,  C07C309/75 ,  C07C311/51 ,  C07C317/22 ,  C07D205/06 ,  C07D205/12 ,  C07D207/408 ,  C07D211/54 ,  C07D213/71 ,  C07D233/84 ,  C07D235/16 ,  C07D235/28 ,  C07D239/40 ,  C07D249/08 ,  C07D249/10 ,  C07D263/32 ,  C07D277/30 ,  C07D295/15 ,  C07D295/26 ,  C07D305/08 ,  C07D307/64 ,  C07D487/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14

摘要： The synthesis of a range of pentylbezene-1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors. Accordingly, the use of such synthetic cannabinoids in the treatment of various disorders mediated by CB1 and CB2 is contemplated.

公开(公告)号：US20220340582A1

公开(公告)日：2022-10-27

申请号：US17765853

申请日：2020-10-02

申请人： CANOPY GROWTH CORPORATION

发明人： SIAWASH AHMAR ,  JUNG YUN KIM ,  PING SHAN LAI ,  JEFFREY ALAN OMEARA ,  QUANG HUY TO

IPC分类号： C07D487/04 ,  C07D311/80 ,  C07D405/12 ,  C07D413/12

摘要： This disclosure relates generally to cannabinoid derivatives having the formula (I), wherein R4 is hydrogen, —C(Q1)N(R4a)(R4b) or —C(R4J)(R4k)N(R4e)C(0)R4f, R6 is hydrogen, —C(Q2)N(R6a)(R6b) or —C(R6J)(R6k)N(R6e)C(0)R6f, provided that R6 is not hydrogen when R4 is hydrogen. Pharmaceutical compositions for the prevention or treatment of a disease associated with a cannabinoid receptor (such as CB1 or CB2) in a subject in need thereof, and methods of using the cannabinoid derivatives are also described.