公开(公告)号：US09353099B2

公开(公告)日：2016-05-31

申请号：US14742556

申请日：2015-06-17

Applicant: CalciMedica, Inc.

Inventor： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC: C07D221/02 ,  A61K31/44 ,  C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C255/60 ,  C07D231/16 ,  C07D231/12 ,  C07D231/14 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07C233/92 ,  C07D213/81 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D471/04

CPC classification number: C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US09133102B2

公开(公告)日：2015-09-15

申请号：US14175449

申请日：2014-02-07

Applicant: Tokyo Ohka Kogyo Co., Ltd.

Inventor： Daichi Takaki ,  Daiju Shiono ,  Yoshiyuki Utsumi ,  Takaaki Kaiho

IPC: C07C233/92 ,  C07C233/91 ,  C07C235/88 ,  C07C233/90 ,  C07D493/08 ,  G03F7/30 ,  G03F7/039 ,  G03F7/20 ,  C08F220/18 ,  C08F220/30 ,  C08F220/40

CPC classification number: C07C233/92 ,  C07C233/90 ,  C07C233/91 ,  C07C235/88 ,  C07D493/08 ,  C08F220/18 ,  C08F220/30 ,  C08F220/40 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/2041 ,  G03F7/30

Abstract: A resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) containing a polymeric compound (A1) having a structural unit (a5) represented by general formula (a5-0) shown below (R1 represents a sulfur atom or an oxygen atom; R2 represents a single bond or a divalent linking group; and Y represents an aromatic hydrocarbon group or an aliphatic hydrocarbon group having a polycyclic group, provided that the aromatic hydrocarbon group or the aliphatic hydrocarbon may have a carbon atom or a hydrogen atom thereof substituted with a substituent.

Abstract translation: 一种抗蚀剂组合物，其包含在酸作用下在显影液中显示出改变的溶解度的碱成分（A）和暴露时产生酸的酸产生剂组分（B），含有高分子化合物（A1）的碱成分（A） 具有下述通式（a5-0）表示的结构单元（a5）（R1表示硫原子或氧原子; R2表示单键或二价连接基团; Y表示芳香族烃基或脂肪族 具有多环基团的烃基，条件是芳族烃基或脂族烃可以具有被取代基取代的碳原子或氢原子。

公开(公告)号：US6087367A

公开(公告)日：2000-07-11

申请号：US314195

申请日：1999-05-18

Applicant: Ronald Breslow ,  Paul A. Marks ,  Richard A. Rifkind ,  Branko Jursic

Inventor： Ronald Breslow ,  Paul A. Marks ,  Richard A. Rifkind ,  Branko Jursic

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/164 ,  A61K31/165 ,  A61K31/167 ,  A61K31/192 ,  A61K31/197 ,  A61K31/20 ,  A61K31/216 ,  A61K31/221 ,  A61K31/275 ,  A61K31/277 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/52 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07C229/24 ,  C07C229/30 ,  C07C233/05 ,  C07C233/06 ,  C07C233/07 ,  C07C233/15 ,  C07C233/25 ,  C07C233/34 ,  C07C233/36 ,  C07C233/43 ,  C07C233/54 ,  C07C233/64 ,  C07C233/92 ,  C07C237/04 ,  C07C237/42 ,  C07C255/19 ,  C07C255/42 ,  C07C255/44 ,  C07C255/60 ,  C07C259/06 ,  C07C259/08 ,  C07C259/10 ,  C07C271/10 ,  C07C271/28 ,  C07C275/28 ,  C07D211/16 ,  C07D211/26 ,  C07D211/32 ,  C07D213/56 ,  C07D213/75 ,  C07D277/02 ,  C07D277/20 ,  C07D277/44 ,  C07D277/46 ,  C07D295/185 ,  C07D487/04 ,  C07D519/00 ,  A01N43/90 ,  A01N37/18 ,  A01N43/40

CPC classification number: C07D213/75 ,  A61K31/16 ,  A61K31/164 ,  A61K31/167 ,  A61K31/197 ,  A61K31/221 ,  A61K31/277 ,  A61K31/427 ,  A61K31/4453 ,  C07C233/05 ,  C07C233/06 ,  C07C233/07 ,  C07C233/15 ,  C07C233/25 ,  C07C233/36 ,  C07C233/43 ,  C07C233/54 ,  C07C233/92 ,  C07C237/42 ,  C07C255/42 ,  C07C255/44 ,  C07C255/60 ,  C07C259/06 ,  C07C259/08 ,  C07C259/10 ,  C07C275/28 ,  C07D211/32 ,  C07D277/46 ,  C07D295/185 ,  C07C2101/14

Abstract: The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

Abstract translation: 本发明提供具有以下结构的化合物：其中R1和R2各自独立地相同或不同; 当R 1和R 2相同时，各自为取代或未取代的芳基氨基，环烷基氨基，吡啶氨基，哌啶子基，9-嘌呤-6-胺或硫代唑氨基; 当R1和R2不同时，R1 = R3-N-R4，其中R3和R4各自独立地相同或不同，为氢原子，羟基，取代或未取代的支链或非支链烷基 ，烯基，环烷基，芳基，烷氧基，芳氧基，芳基烷氧基或吡啶基，或R3和R4键合在一起形成哌啶基，R2是羟基氨基，羟基，氨基，烷基氨基，二烷基氨基或烷氧基; 并且n为约4至约8的整数。本发明还提供了选择性诱导肿瘤细胞的终末分化并由此抑制这些细胞增殖的方法。 此外，本发明提供了治疗具有以肿瘤细胞增殖为特征的肿瘤的患者的方法。 最后，本发明提供包含药学上可接受的载体和治疗上可接受量的上述化合物的药物组合物。

公开(公告)号：US5025033A

公开(公告)日：1991-06-18

申请号：US301065

申请日：1989-01-25

Applicant: Giichi Goto ,  Akinobu Nagaoka

Inventor： Giichi Goto ,  Akinobu Nagaoka

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/47 ,  A61P25/02 ,  A61P25/28 ,  A61P43/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/40 ,  C07C233/78 ,  C07C233/91 ,  C07C233/92 ,  C07C235/34 ,  C07C237/00 ,  C07C237/20 ,  C07C237/22 ,  C07C237/28 ,  C07C237/34 ,  C07C237/42 ,  C07C255/57 ,  C07C255/58 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C317/44 ,  C07C323/60 ,  C07C323/62 ,  C07D209/48 ,  C07D217/12 ,  C07D401/06

CPC classification number: C07D209/48 ,  C07C233/40 ,  C07C235/34 ,  C07C237/20 ,  C07C237/22 ,  C07C255/57 ,  C07C317/44 ,  C07D401/06

Abstract: A cholinesterase inhibiting agent which contains an alkylene diamine of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently is a hydrogen atom or a hydrocarbon residue which may optionally be substituted, or R.sup.1 and R.sup.2 combinedly form, together with the adjacent nitrogen atom, a condensed heterocyclic group, R.sup.3 is a hydrogen atom or a hydrocarbon residue or an acyl group which may optionally be substituted and R.sup.4 is a hydrogen atom, or R.sup.3 and R.sup.4 combinedly form a group of the formula ##STR2## or --(CH.sub.2).sub.m+1 -- (m being 0, 1 or 2), A is --(CH.sub.2).sub.l -- (l being 0, 1 or 2) or --CH.dbd.CH--, X is a substituent or substituents and n is an integer of 4 to 7, or a salt thereof, which are useful as cerebral function improving agents for the prevention or treatment of senile dementia, Alzheimer's disease, Huntington's chorea, hyperkinesia, mania and so forth.

公开(公告)号：US4950666A

公开(公告)日：1990-08-21

申请号：US331563

申请日：1989-03-30

Applicant: Clinton J. Peake ,  Thomas G. Cullen ,  Anthony J. Martinez

Inventor： Clinton J. Peake ,  Thomas G. Cullen ,  Anthony J. Martinez

IPC: A01N35/02 ,  A01N37/02 ,  A01N37/06 ,  A01N37/12 ,  A01N37/18 ,  A01N37/20 ,  A01N37/22 ,  A01N37/34 ,  A01N37/38 ,  A01N37/52 ,  A01N41/06 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/40 ,  A01N43/84 ,  A01N47/02 ,  A01N47/34 ,  C07C233/09 ,  C07C233/13 ,  C07C233/15 ,  C07C233/20 ,  C07C233/49 ,  C07C233/55 ,  C07C233/91 ,  C07C233/92 ,  C07C243/30 ,  C07C255/14 ,  C07C255/29 ,  C07C259/06 ,  C07C259/14 ,  C07C259/18 ,  C07C317/40 ,  C07D213/71 ,  C07D213/75 ,  C07D295/185 ,  C07D307/42 ,  C07D307/79 ,  C07D333/16 ,  C07D333/18 ,  C07D333/20 ,  C07D333/28

CPC classification number: C07D213/75 ,  A01N35/02 ,  A01N37/02 ,  A01N37/06 ,  A01N37/12 ,  A01N37/18 ,  A01N37/20 ,  A01N37/22 ,  A01N37/34 ,  A01N37/38 ,  A01N37/52 ,  A01N41/06 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/36 ,  A01N43/40 ,  A01N43/84 ,  A01N47/02 ,  A01N47/34 ,  C07C233/09 ,  C07C233/13 ,  C07C233/15 ,  C07C233/20 ,  C07C233/49 ,  C07C233/55 ,  C07C233/91 ,  C07C233/92 ,  C07C243/30 ,  C07C255/14 ,  C07C255/29 ,  C07C259/06 ,  C07C259/14 ,  C07C259/18 ,  C07C317/40 ,  C07D213/71 ,  C07D295/185 ,  C07D307/42 ,  C07D307/79 ,  C07D333/16 ,  C07D333/18 ,  C07D333/20 ,  C07D333/28 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/14

Abstract: The present invention discloses compounds of the formula ##STR1## in which R is a 1,1-difluoroalkyl group or a 1,1-difluoroethenyl group having an even numbered carbon chain length of from 4 to 22 carbon atoms, pesticidal compositions thereof; and their use to control plant pests such as insects, acarids, and nematodes.

Abstract translation: 本发明公开了具有偶数碳链长度为4至22个碳原子的1,1-二氟烷基或1,1-二氟乙烯基的式Ⅰ化合物，其农药组成; 以及其用于控制​​植物害虫如昆虫，螨虫和线虫的用途。

公开(公告)号：US11384060B2

公开(公告)日：2022-07-12

申请号：US16477072

申请日：2018-01-22

Applicant: ALPHALA CO., LTD.

Inventor： Cheng-Ho Chung ,  Shi-Liang Tseng ,  Yung-Ning Yang ,  Yen-Fu Chen

IPC: C07D233/92 ,  C07D257/04 ,  C07D277/66 ,  C07D471/04 ,  C07D417/04 ,  C07D307/81 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/12 ,  C07D263/57 ,  C07D213/56 ,  C07D491/04 ,  C07D271/06 ,  C07D271/10 ,  C07D271/113 ,  C07D401/04 ,  C07D401/12 ,  C07D231/18 ,  C07D403/04 ,  C07D239/34 ,  C07D237/14 ,  C07D333/60 ,  A61P3/10 ,  C07D307/79 ,  C07C233/92 ,  C07D209/08 ,  C07D213/90 ,  C07D271/07

Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: (I), in which each of variables R1, R2, R3, R4, R5, A1, A2, A3, A4, X and Y is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.

公开(公告)号：US09090612B2

公开(公告)日：2015-07-28

申请号：US14267759

申请日：2014-05-01

Applicant: CalciMedica, Inc.

Inventor： Jeffrey P. Whitten ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC: C07D221/02 ,  C07D471/04 ,  C07C233/75 ,  C07C233/80 ,  C07C255/60 ,  C07D231/16 ,  C07D231/12 ,  C07D231/14 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07C233/92 ,  C07D213/81 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38

CPC classification number: C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

Abstract translation: 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。

公开(公告)号：US20140243366A1

公开(公告)日：2014-08-28

申请号：US14267759

申请日：2014-05-01

Applicant: CalciMedica, Inc.

Inventor： Jeffrey P. WHITTEN ,  Yazhong Pei ,  Jianguo Cao ,  Zhijun Wang ,  Evan Rogers ,  Brian Dyck ,  Jonathan Grey

IPC: C07D471/04 ,  C07D401/12 ,  C07D213/81 ,  C07D417/12 ,  C07D413/04 ,  C07D277/34 ,  C07D231/56 ,  C07D405/12 ,  C07D231/18 ,  C07D333/38 ,  C07D317/62 ,  C07C233/92 ,  C07D277/56 ,  C07D417/14 ,  C07D409/14 ,  C07D263/57 ,  C07D413/14

CPC classification number: C07D417/12 ,  C07C233/75 ,  C07C233/80 ,  C07C233/92 ,  C07C255/60 ,  C07C2601/02 ,  C07D213/81 ,  C07D231/12 ,  C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/56 ,  C07D263/57 ,  C07D277/34 ,  C07D277/56 ,  C07D317/62 ,  C07D333/38 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

公开(公告)号：US6362369B2

公开(公告)日：2002-03-26

申请号：US25026199

申请日：1999-02-16

Applicant: NIHON NOHYAKU CO LTD

Inventor： TOHNISHI MASANORI ,  NAKAO HAYAMI ,  KOHNO EIJI ,  NISHIDA TATEKI ,  FURUYA TAKASHI ,  SHIMIZU TOSHIAKI ,  SEO AKIRA ,  SAKATA KAZUYUKI ,  FUJIOKA SHINSUKE ,  KANNO HIDEO

IPC: C07C211/52 ,  C07C233/65 ,  C07C233/66 ,  C07C233/75 ,  C07C233/81 ,  C07C233/91 ,  C07C233/92 ,  C07C235/64 ,  C07C235/84 ,  C07C237/22 ,  C07C251/48 ,  C07C255/57 ,  C07C261/04 ,  C07C271/20 ,  C07C271/64 ,  C07D213/40 ,  C07D213/70 ,  C07D263/32 ,  C07D277/30 ,  C07D295/192 ,  C07D307/52 ,  C07D333/20 ,  C07F9/18 ,  C07F9/40 ,  A01N37/18 ,  C07C233/05

CPC classification number: C07D213/40 ,  C07C211/52 ,  C07C233/65 ,  C07C233/66 ,  C07C233/75 ,  C07C233/81 ,  C07C233/91 ,  C07C233/92 ,  C07C235/64 ,  C07C235/84 ,  C07C237/22 ,  C07C251/48 ,  C07C255/57 ,  C07C261/04 ,  C07C271/20 ,  C07C271/64 ,  C07D213/70 ,  C07D263/32 ,  C07D277/30 ,  C07D295/192 ,  C07D307/52 ,  C07D333/20 ,  C07F9/18 ,  C07F9/4021

Abstract: The present invention provides a phthalic acid diamide derivative represented by the general formula (I)(wherein R1, R2 and R3 are each H, C3-C6 cycloalkyl group, group of the formula -A1-Ql or the like; X may be the same or different and are each halogen atom, nitro group, phenyl group, group of the formula -A2-R7 or the like; n is 1 to 4; Y may be same or different and are each halogen atom, cyano group, phenyl group, group of the formula -A2-R7 or the like; m is 1 to 5; Z1 and Z2 are each 0 or S), fluorine-containing aniline compound represented by the general formula (ST-I) as starting material for said phthalic acid diamide derivative(wherein Ra is halogen atom, C1-C6 alkyl group or the like and Rb, Rc and Rd is H or C2-C6 perfluoroalkyl group), and an agricultural and horticultural insecticide containing said phthaldiamide derivative, as well as to provide a method for use of said insecticide. The agricultural and horticultural insecticides of the present invention show excellent activities for controlling injurious insects.

Abstract translation: 本发明提供由通式（I）表示的邻苯二甲酸二酰胺衍生物（其中R1，R2和R3分别为H，C3-C6环烷基，式-A1-Q1等基团等; X可以是 相同或不同，各自为卤原子，硝基，苯基，式-A2-R7等基团; n为1至4; Y可以相同或不同，各自为卤素原子，氰基，苯基 式-A2-R7等基团; m为1〜5; Z 1和Z 2各自为0或S），由通式（ST-I）表示的含氟苯胺化合物作为所述邻苯二甲酸 酸式二酰胺衍生物（其中Ra为卤素原子，C1-C6烷基等，Rb，Rc和Rd为H或C2-C6全氟烷基），以及含有所述邻苯二甲酰胺衍生物的农业和园艺杀虫剂，以及提供 一种使用所述杀虫剂的方法。 本发明的农业和园艺杀虫剂显示出控制有害昆虫的优良活性。

公开(公告)号：US5481022A

公开(公告)日：1996-01-02

申请号：US256646

申请日：1994-07-19

Applicant: Tetsuo Takematsu ,  Takashi Kume ,  Shoji Yamaoka ,  Takeo Komata ,  Kiyoshi Suzuki ,  Yukio Ikeda ,  Matsue Kawamura ,  Yumiko Koda ,  Kaoru Mori

Inventor： Tetsuo Takematsu ,  Takashi Kume ,  Shoji Yamaoka ,  Takeo Komata ,  Kiyoshi Suzuki ,  Yukio Ikeda ,  Matsue Kawamura ,  Yumiko Koda ,  Kaoru Mori

IPC: A01N37/30 ,  A01N37/36 ,  A01N37/38 ,  C07C231/08 ,  C07C233/92 ,  C07C235/68 ,  C07C235/88 ,  C07C257/02 ,  C07C229/38 ,  A01N37/10

CPC classification number: C07C235/88 ,  A01N37/36 ,  A01N37/38 ,  C07C235/68 ,  C07C257/02 ,  C07C2101/16

Abstract: The invention provides N-aryloxyacyl-N-phenyltetrahydrophthalamic acid derivatives represented by the general formula [I], a method of producing the same, and a herbicide containing the same as the effective components, ##STR1## wherein X and Y each individually represent hydrogen atoms or halogen atoms, Ar represents a substituted or unsubstituted phenyl group or naphthyl group, R.sup.1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a lower alkynyloxy group, a lower alkoxyalkoxy group or a lower alkoxycarbonylalkoxy group, R.sup.2 represents a hydrogen atom or a lower alkyl group, R.sup.3 represents a hydroxyl, a lower alkoxy group, a lower alkenyloxy group, a lower alkynyloxy group, a lower alkoxyalkoxy group, a benzyloxy group or a lower alkoxycarbonylalkoxy group, and m is an integer ranging from 0 to 5. This herbicide which is very useful can be widely applied to upland, paddy field, orchard, turf, forest, non-crop land, etc., and is not harmful to crops.

Abstract translation: PCT No.PCT / JP93 / 01756 Sec。 371日期：1994年7月19日 102（e）日期1994年7月19日PCT 1993年12月2日PCT公布。 公开号WO94 / 12469 日期：1994年6月9日本发明提供由通式[I]表示的N-芳氧基酰基-N-苯基四氢酞酸衍生物，其制备方法和含有与有效成分相同的除草剂， I]其中X和Y各自独立地表示氢原子或卤原子，Ar表示取代或未取代的苯基或萘基，R1表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烯氧基 低级烷氧基，低级烷氧基烷氧基或低级烷氧羰基烷氧基，R2表示氢原子或低级烷基，R3表示羟基，低级烷氧基，低级链烯氧基，低级炔氧基，低级烷氧基 烷氧基烷氧基，苄氧基或低级烷氧基羰基烷氧基，m为0〜5的整数。该除草剂非常有用，可广泛应用于高地，水田，果园，草坪，森林， - 耕地等，对作物无害。