公开(公告)号：US20240216128A1

公开(公告)日：2024-07-04

申请号：US18601399

申请日：2024-03-11

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN ,  Eran MILLER ,  Yuval ZIPORY ,  Tal REICH ,  Meir KUTZIK ,  Rotem NEEMAN

IPC: A61F2/24 ,  A61B17/00 ,  A61B17/122 ,  A61F2/848

CPC classification number: A61F2/2418 ,  A61B17/122 ,  A61F2/2409 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2466 ,  A61B2017/00243 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2463 ,  A61F2/848 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0013 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0015 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

Abstract: For some applications, apparatus is provided for facilitating implantation of a prosthetic valve (150) at a native heart valve (120) of a subject, the apparatus comprising a prosthetic valve support (22), the prosthetic valve support (a) being configured to be transluminally-deliverable to the native valve and to be deployable at the native valve, and (b) comprising one or more tissue-engaging elements (24), configured to couple the prosthetic valve support to leaflets (128) of the native valve without eliminating check valve functionality of the native valve. Other embodiments are also described.

公开(公告)号：US20230248352A1

公开(公告)日：2023-08-10

申请号：US18136504

申请日：2023-04-19

Applicant: CARDIOVALVE LTD.

Inventor： Yossi GROSS ,  Gil HACOHEN ,  Eran MILLER ,  Yuval ZIPORY ,  Tal REICH

IPC: A61B17/04 ,  A61F2/24

CPC classification number: A61B17/0401 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61F2/2466 ,  A61F2/2427 ,  A61F2/243 ,  A61F2/2412 ,  A61F2220/0016 ,  A61F2230/0041 ,  A61F2230/005 ,  A61B2017/00243

Abstract: Apparatus and methods are described including a prosthetic valve support (40) configured to be placed at a patient's native atrioventricular valve annulus. The valve support defines an annular element (44) that defines an inner cross-sectional area thereof. An expandable prosthetic valve (80) is placed into the patient's ventricle, the prosthetic valve including an expandable frame (79) and prosthetic valve leaflets (82) coupled to the frame. When the frame is in a non-constrained state thereof, a cross-sectional area of the frame, along at least a given portion L of the frame's length, is greater than the cross-sectional area defined by the annular element. The prosthetic valve is couplable to the prosthetic valve support at any location along the portion, by the frame being expanded when the location along the portion is aligned with the annular element. Other applications are also described.

公开(公告)号：US20240415647A1

公开(公告)日：2024-12-19

申请号：US18749731

申请日：2024-06-21

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24 ,  A61F2/82

Abstract: An implant includes a support frame, having a compressed state, and an expanded state in which the support frame defines an opening therethrough, and is dimensioned to be placed against an upstream surface of a native heart valve. The implant includes a valve frame having a compressed state, and an expanded state in which the valve frame defines a lumen therethrough, and including a valve member disposed within the lumen. The valve frame is coupled to the support frame via a flexible sheet such that when the support and valve frames are in their expanded state, the valve frame is not in contact with the support frame. The implant is housed in the catheter for implanting transfemorally, with the valve frame closer to a distal end of the catheter than the support frame is to the distal end of the catheter. Other embodiments are also described.

公开(公告)号：US20200046496A1

公开(公告)日：2020-02-13

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yaron HERMAN ,  Yuval ZIPORY ,  Eran HOFFER ,  Michael ALBITOV ,  Natalia KRUGLOVA ,  Tal REICH ,  Ilia HARITON ,  Aviram BAUM

IPC: A61F2/24

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US20240058123A1

公开(公告)日：2024-02-22

申请号：US18385643

申请日：2023-10-31

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval ZIPORY ,  Tal REICH ,  Yaron HERMAN ,  Gil HACOHEN ,  Eran MILLER ,  Rotem NEEMAN ,  Natalia KRUGLOVA

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2436 ,  A61F2/2418 ,  A61F2/2409 ,  A61F2220/0075 ,  A61F2250/0098 ,  A61F2220/0025 ,  A61F2220/0016 ,  A61F2210/0076

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US20200146824A1

公开(公告)日：2020-05-14

申请号：US16746489

申请日：2020-01-17

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni IAMBERGER ,  Yuval ZIPORY ,  Michael ALBITOV ,  Tal REICH ,  Ilia HARITON

IPC: A61F2/24

Abstract: Embodiments of the present disclosure provide an apparatus comprising a delivery tool and a prosthetic valve, the prosthetic valve comprising a first frame, and a second frame coupled to the first frame. The delivery tool comprises a first catheter, a second catheter, and a rod. A steerable portion of the second catheter extends out of the first catheter, and a steerable distal portion of the rod extends out of the second catheter. An extracorporeal rod-controller is operably coupled to the rod such that operating the extracorporeal rod-controller steers the steerable distal portion of the rod. In a delivery state of the apparatus, the prosthetic valve is compressed onto the rod, distal to the distal end of the second catheter, and the apparatus is transfemorally and transseptally advanceable into a left atrium of a heart of a subject. Other embodiments are also described.