公开(公告)号：US20220259275A1

公开(公告)日：2022-08-18

申请号：US17595960

申请日：2020-05-28

Applicant: Case Western Reserve University

Inventor： Parameswaran Ramakrishnan ,  Jonathan K. Pokorski

IPC: C07K14/47 ,  A61P35/02 ,  A61P37/00

Abstract: The present disclosure relates to peptoids for inhibiting O-GlcNAcylated proteins, and in particular, the c-Rel peptide of NF-kappaB. The compounds can be used in the prevention or treatment of diseases of conditions having elevated levels of O-GlcNAcylation, such as autoimmune diseases, conditions that are related to hyperglycemia, or cancers.

公开(公告)号：US20190175781A1

公开(公告)日：2019-06-13

申请号：US16026228

申请日：2018-07-03

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Jonathan K. Pokorski ,  Eric Baer ,  Sieun Kim ,  Jia Wang

IPC: A61L15/26 ,  A61L15/44 ,  A61F2/02 ,  A61L27/60

CPC classification number: A61L15/26 ,  A61F2/02 ,  A61L15/44 ,  A61L27/60 ,  A61L2400/12

Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.