公开(公告)号：US20210402063A1

公开(公告)日：2021-12-30

申请号：US17474985

申请日：2021-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L89/06 ,  C08L5/04 ,  C08B37/00 ,  C08H1/06 ,  A61L27/26 ,  A61L27/38 ,  C08G65/00 ,  A61L27/20

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US11116875B2

公开(公告)日：2021-09-14

申请号：US16107774

申请日：2018-08-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L24/04 ,  A61L24/00 ,  A61L27/20 ,  A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08L89/06 ,  C08L5/04 ,  C08B37/00 ,  C08H1/06 ,  A61L27/26 ,  A61L27/38 ,  C08G65/00

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US20190054207A1

公开(公告)日：2019-02-21

申请号：US16107774

申请日：2018-08-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L27/20

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.

公开(公告)号：US11944722B2

公开(公告)日：2024-04-02

申请号：US17474985

申请日：2021-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Tae-Hee Kim

IPC: A61L24/04 ,  A61L24/00 ,  A61L27/20 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/00 ,  C08G65/00 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06

CPC classification number: A61L27/44 ,  A61L27/20 ,  A61L27/26 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/0084 ,  C08G65/002 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2400/16 ,  A61L2430/40 ,  C08L2205/04 ,  C08L2312/00 ,  C08L5/04 ,  C08L89/06 ,  C08L89/06 ,  C08L5/04 ,  A61L27/26 ,  C08L89/06 ,  A61L27/26 ,  C08L5/08

Abstract: A composition includes a dual crosslinkable hydrogel that includes a plurality of polymer macromers, which are crosslinked with a first agent and a second agent different than the first agent, wherein the crosslinks formed using the second agent are reversible and repeatable to allow the mechanical properties of the hydrogel to be dynamically adjusted.