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公开(公告)号：US11628299B2
公开(公告)日：2023-04-18
申请号：US16341511
申请日：2017-10-17
发明人： Tina Vrabec , Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore
摘要： The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.
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公开(公告)号：US20200001073A1
公开(公告)日：2020-01-02
申请号：US16565841
申请日：2019-09-10
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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3.发明授权Therapy delivery devices and methods for non-damaging neural tissue conduction block 有权治疗传递装置和方法用于非破坏性神经组织传导阻滞公开(公告)号：US09387322B2
公开(公告)日：2016-07-12
申请号：US14408017
申请日：2013-06-14
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
CPC分类号： A61N1/0556 , A61N1/06 , A61N1/20 , A61N1/36064 , A61N1/36067 , A61N1/36071
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
摘要翻译： 通过神经组织阻断信号传导的装置和方法。 方法的一个步骤包括将治疗递送装置放置成与神经组织电连通。 治疗递送装置包括具有高电荷容量材料的电极接触。 可以将多相直流（DC）应用于神经组织而不损伤神经组织。 多相DC包括阴极DC相和阳极DC相，其共同产生神经阻滞并减少由治疗递送装置递送的电荷。 DC输送可以与高频交流（HFAC）模块组合，以产生提供有效，安全，长期阻挡的系统，而不会引发发作响应。
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公开(公告)号：US11033734B2
公开(公告)日：2021-06-15
申请号：US16266236
申请日：2019-02-04
发明人： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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公开(公告)号：US10828485B2
公开(公告)日：2020-11-10
申请号：US15760246
申请日：2016-09-30
摘要： The present disclose generally relates to high-charge capacity electrodes that include a substrate and a coating covering at least a portion of the substrate that includes active particles held together by a biocompatible binding material. One aspect of the present disclosure relates a system that can block conduction in a nerve. The system can include a current generator that generates a direct current (DC). The system can also include a high-charge capacity electrode that can be coupled to the current generator to deliver the DC to block conduction in a nerve.
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公开(公告)号：US10195434B2
公开(公告)日：2019-02-05
申请号：US15344959
申请日：2016-11-07
发明人： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
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公开(公告)号：US20170050024A1
公开(公告)日：2017-02-23
申请号：US15344959
申请日：2016-11-07
发明人： Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore , Scott Lempka , Jesse Wainright , Tina Vrabec , Manfred Franke
CPC分类号： A61N1/36071 , A61N1/0456 , A61N1/0551 , A61N1/0556 , A61N1/06 , A61N1/20 , A61N1/205 , A61N1/36017 , A61N1/36021 , A61N1/36062 , A61N1/36125 , A61N1/3615 , A61N1/36171
摘要： Described herein are systems and methods for the treatment of pain using electrical nerve conduction block (ENCB). Contrary to other methods of pain treatment, the ENCB can establish a direct block of neural activity, thereby eliminating the pain. Additionally, the ENCB can be administered without causing electrochemical damage. An example method can include: placing at least one electrode contact in electrical communication with a region of a subject's spinal cord; applying an electrical nerve conduction block (ENCB) to a nerve in the region through the at least one electrode contact; and blocking neural activity with the ENCB to reduce the pain or other unwanted sensation in the subject.
摘要翻译： 本文描述了使用电神经传导阻滞（ENCB）治疗疼痛的系统和方法。 与其他疼痛治疗方法相反，ENCB可建立直接阻断神经活动，从而消除疼痛。 另外，ENCB可以在不引起电化学损伤的情况下进行施用。 示例性方法可以包括：将至少一个电极接触件放置在与受试者的脊髓区域电连通中; 通过所述至少一个电极接触将电神经传导阻滞（ENCB）施加到所述区域中的神经; 并用ENCB阻断神经活动，以减少受试者的疼痛或其他不希望的感觉。
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公开(公告)号：US20230086695A1
公开(公告)日：2023-03-23
申请号：US17991045
申请日：2022-11-21
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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公开(公告)号：US20200001078A1
公开(公告)日：2020-01-02
申请号：US16341511
申请日：2017-10-17
发明人： Tina Vrabec , Niloy Bhadra , Narendra Bhadra , Kevin L. Kilgore
摘要： The present disclosure relates to subcutaneous direct current (DC) nerve conduction block. A subcutaneous electrode can be implanted under a subject's skin between the subject's skin and a neural structure within the subject's body. The subcutaneous electrode can be coupled to a current generator. A DC can be configured by the current generator and delivered through the subcutaneous electrode to block conduction in the neural structure. The subcutaneous electrode eliminates an effect of an impedance of the subject's skin on the DC. The DC can be returned to the current generator by a return electrode.
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公开(公告)号：US10441782B2
公开(公告)日：2019-10-15
申请号：US16106092
申请日：2018-08-21
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.
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