公开(公告)号：US10338075B2

公开(公告)日：2019-07-02

申请号：US15346547

申请日：2016-11-08

申请人： Celera Corporation

发明人： Charles Birse ,  Steve Ruben ,  Marcia Lewis ,  Mehdi Mesri

IPC分类号： G01N33/53 ,  G01N33/574 ,  C12Q1/6886

摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

公开(公告)号：US09090682B2

公开(公告)日：2015-07-28

申请号：US14098888

申请日：2013-12-06

申请人： CELERA CORPORATION

发明人： Steve Ruben ,  Bruno Domon ,  Candy Lee

IPC分类号： G01N33/574 ,  C07K16/18 ,  G01N33/68 ,  C07K14/47 ,  C12N15/113 ,  C12Q1/68

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。

公开(公告)号：US09658232B2

公开(公告)日：2017-05-23

申请号：US14744629

申请日：2015-06-19

申请人： CELERA CORPORATION

发明人： Steve Ruben ,  Bruno Domon ,  Candy Lee

IPC分类号： G01N33/574 ,  G01N33/68 ,  C07K14/47 ,  C07K16/18 ,  C12N15/113 ,  C12Q1/68 ,  A61K47/48 ,  A61K38/00 ,  A61K39/00

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

公开(公告)号：US11105806B2

公开(公告)日：2021-08-31

申请号：US16456363

申请日：2019-06-28

申请人： Celera Corporation

发明人： Charles Birse ,  Steve Ruben ,  Marcia Lewis ,  Mehdi Mesri

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

公开(公告)号：US20190233484A1

公开(公告)日：2019-08-01

申请号：US16210539

申请日：2018-12-05

申请人： CELERA CORPORATION

发明人： Elizabeth Joseloff ,  Steve Ruben ,  Tao He

IPC分类号： C07K14/47 ,  C07K14/435 ,  C07K16/18 ,  C12Q1/6876 ,  G01N33/53 ,  C12Q1/6886 ,  C12N15/113 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K2039/505 ,  C07K14/435 ,  C07K16/18 ,  C07K16/3038 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/57438 ,  G01N33/57484 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/10 ,  Y10T436/143333

摘要： The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

公开(公告)号：US08632987B2

公开(公告)日：2014-01-21

申请号：US13670293

申请日：2012-11-06

申请人： Celera Corporation

发明人： Steve Ruben ,  Bruno Domon ,  Candy Lee

IPC分类号： G01N33/574

CPC分类号： G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

摘要： Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

摘要翻译： 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。

公开(公告)号：US11802164B2

公开(公告)日：2023-10-31

申请号：US16747791

申请日：2020-01-21

申请人： Celera Corporation

发明人： Steve Ruben ,  Tao He ,  Candy Lee ,  Karen Van Orden ,  Paul Moore

IPC分类号： C07H21/04 ,  C07K16/30 ,  C07K14/705 ,  C07K16/40 ,  C12N9/64 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/574 ,  C07K14/47 ,  C07K16/18 ,  C07K16/28 ,  C12N9/18 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K16/3076 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70546 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/2839 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/303 ,  C07K16/40 ,  C12N9/18 ,  C12N9/6424 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12Q1/6886 ,  G01N33/57488 ,  G01N33/57492 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q2600/158 ,  C12Y301/01 ,  C12Y304/21 ,  C12Y304/21109

摘要： Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.