公开(公告)号：US20200149056A1

公开(公告)日：2020-05-14

申请号：US16719544

申请日：2019-12-18

Applicant: CELLECTIS

Inventor： Luc Mathis ,  Zachary Demorest ,  Feng Zhang ,  William Haun

IPC: C12N15/82 ,  A01H5/10 ,  A23D9/00 ,  A01H1/06 ,  A01H6/54

Abstract: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD3A, FAD3B, and FAD3C genes.

公开(公告)号：US20200002709A1

公开(公告)日：2020-01-02

申请号：US16328323

申请日：2017-08-30

Applicant: CELLECTIS

Inventor： Song Luo ,  Benjamin Clasen ,  Feng Zhang ,  Nicholas J. Baltes ,  Javier Gil Humanes

IPC: C12N15/82

Abstract: Materials and methods are provided for making plants (e.g., soybean varieties, wheat varieties, or corn varieties) with altered amino acid content. For example, materials and methods are provided for making TALE nuclease-induced mutations in genes encoding seed storage proteins, or by making TALE nuclease-induced deletions of within seed storage protein genes.

公开(公告)号：US20190211349A1

公开(公告)日：2019-07-11

申请号：US16326549

申请日：2017-08-18

Applicant: CELLECTIS

Inventor： Benjamin Clasen ,  Song Luo ,  Daniel F. Voytas ,  Feng Zhang

IPC: C12N15/82 ,  C12N15/52

CPC classification number: C12N15/8261 ,  C12N9/0059 ,  C12N15/52 ,  C12N15/8242 ,  C12Y110/03001

Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with resistance to black-spot bruising, specifically, by making TALE-nuclease-induced mutations in genes encoding tuber specific expressed polyphenol oxidase.

公开(公告)号：US20150272076A1

公开(公告)日：2015-10-01

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H5/12 ,  A01H1/06 ,  C12P21/00

CPC classification number: A01H5/12 ,  A01H1/06 ,  C12N9/22 ,  C12N15/01 ,  C12N15/8218 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12P21/005

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制造适合于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。

公开(公告)号：US20210059142A1

公开(公告)日：2021-03-04

申请号：US17098210

申请日：2020-11-13

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US10301637B2

公开(公告)日：2019-05-28

申请号：US14744386

申请日：2015-06-19

Applicant: CELLECTIS

Inventor： Benjamin Clasen ,  Daniel F. Voytas ,  Feng Zhang

IPC: C12N15/82 ,  C08B30/04

Abstract: Materials and methods for making plants (e.g., Solanum varieties) with decreased levels of amylose are provided herein. The methods can include making mutations in the gene encoding granule bound starch synthase (GBSS), where the mutations are induced using a rare-cutting endonuclease.

公开(公告)号：US20190024103A1

公开(公告)日：2019-01-24

申请号：US16053194

申请日：2018-08-02

Applicant: CELLECTIS

Inventor： Luc Mathis ,  Zachary Demorest ,  Feng Zhang ,  William Haun

IPC: C12N15/82 ,  A01H5/10 ,  A01H6/54

CPC classification number: C12N15/8247 ,  A01H1/06 ,  A01H5/10 ,  A01H6/542 ,  A23D9/00 ,  C12N15/8205 ,  C12N15/8274 ,  C12N15/8286 ,  Y02A40/162

Abstract: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD3A, FAD3B, and FAD3C genes.

公开(公告)号：US20140370558A1

公开(公告)日：2014-12-18

申请号：US14208027

申请日：2014-03-13

Applicant: CELLECTIS

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Feng Zhang ,  William Haun

IPC: C12N15/01 ,  C12P7/64

CPC classification number: C12N15/01 ,  C12N9/0071 ,  C12N15/8247 ,  C12P7/6445 ,  C12Y114/19006

Abstract: Materials and methods are provided for making soybean varieties that have altered oil composition as a result of mutations in the FAD2-1A and FAD2-1B genes.

Abstract translation: 提供材料和方法用于制造由于FAD2-1A和FAD2-1B基因突变而导致油组成变化的大豆品种。

公开(公告)号：US20160037742A1

公开(公告)日：2016-02-11

申请号：US14653604

申请日：2013-12-20

Applicant: CELLECTIS

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Feng Zhang ,  Benjamin Clasen ,  William Haun ,  Thomas Stoddard

IPC: A01H5/04 ,  A23L1/217

CPC classification number: C12N15/01 ,  A23V2002/00 ,  C12N15/8245

Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.

Abstract translation: 提供了材料和方法，用于制备在冷藏土豆中还原糖和丙烯酰胺积累减少的茄属品种，特别是通过在编码液泡转化酶的基因中产生TALE-核酸酶诱导的突变。

公开(公告)号：US20150291967A1

公开(公告)日：2015-10-15

申请号：US14439413

申请日：2013-10-31

Applicant: Luc MATHIS ,  Daniel VOYTAS ,  Jin LI ,  Feng ZHANG ,  Song LUO ,  CELLECTIS

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Song Luo

IPC: C12N15/82

CPC classification number: C12N15/8213 ,  C12N15/8209 ,  C12N15/8274 ,  C12N15/8278

Abstract: The present invention relates to methods allowing the targeted insertion of transgenes into a plant genome at desired loci by using homologous recombination combined with rare-cutting endonucleases without the need of inserting an exogenous selectable marker.

Abstract translation: 本发明涉及通过使用与稀有切割内切核酸酶组合的同源重组而不需要插入外源选择性标记的方法，允许将转基因靶向插入到所需基因座的植物基因组中。