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公开(公告)号：US20210059142A1
公开(公告)日：2021-03-04
申请号：US17098210
申请日：2020-11-13
Applicant: CELLECTIS SA , MEDICAGO INC.
Inventor： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
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公开(公告)号：US20160037742A1
公开(公告)日：2016-02-11
申请号：US14653604
申请日：2013-12-20
Applicant: CELLECTIS
Inventor： Luc Mathis , Daniel F. Voytas , Feng Zhang , Benjamin Clasen , William Haun , Thomas Stoddard
CPC classification number: C12N15/01 , A23V2002/00 , C12N15/8245
Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
Abstract translation: 提供了材料和方法，用于制备在冷藏土豆中还原糖和丙烯酰胺积累减少的茄属品种，特别是通过在编码液泡转化酶的基因中产生TALE-核酸酶诱导的突变。
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公开(公告)号：US20170081672A1
公开(公告)日：2017-03-23
申请号：US15056544
申请日：2016-02-29
Applicant: CELLECTIS
Inventor： Thomas Stoddard , Song Luo
CPC classification number: C12N15/52 , A01H4/008 , C12N9/22 , C12N15/8241 , C12N2840/10 , C12Y301/00
Abstract: Materials and methods for genome engineering through transient expression of a targeted nuclease are described herein. For example, the methods described herein can include introducing into a cell a messenger RNA (mRNA) that encodes a nuclease targeted to a selected sequence within the cell, where the stability of the mRNA is modified by the addition of untranslated regions (UTRs).
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公开(公告)号：US20150272076A1
公开(公告)日：2015-10-01
申请号：US14439420
申请日：2013-10-31
Applicant: CELLECTIS SA , MEDICAGO INC.
Inventor： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
CPC classification number: A01H5/12 , A01H1/06 , C12N9/22 , C12N15/01 , C12N15/8218 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12P21/005
Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
Abstract translation: 提供材料和方法用于制造适合于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。
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公开(公告)号：US20210002656A1
公开(公告)日：2021-01-07
申请号：US17022421
申请日：2020-09-16
Applicant: CELLECTIS
Inventor： Daniel F. Voytas , Feng Zhang , Jin Li , Thomas Stoddard , Song Luo
Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.
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Patent Agency Ranking
公开(公告)号：US20200157525A1
公开(公告)日：2020-05-21
申请号：US16664245
申请日：2019-10-25
Applicant: CELLECTIS
Inventor： Luc Mathis , Daniel F. Voytas , Feng Zhang , Benjamin Clasen , William Haun , Thomas Stoddard
Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
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公开(公告)号：US20170258024A1
公开(公告)日：2017-09-14
申请号：US15334017
申请日：2016-10-25
Applicant: CELLECTIS
Inventor： Luc Mathis , Daniel F. Voytas , Feng Zhang , Benjamin Clasen , William Haun , Thomas Stoddard
CPC classification number: C12N15/01 , A23V2002/00 , C12N15/8245
Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
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公开(公告)号：US20160138040A1
公开(公告)日：2016-05-19
申请号：US14941034
申请日：2015-11-13
Applicant: CELLECTIS
Inventor： Daniel F. Voytas , Thomas Stoddard , Feng Zhang , Luc Mathis
IPC: C12N15/82
CPC classification number: C12N15/8274 , C12N15/8217 , C12N15/8278
Abstract: Materials and methods for making plants (e.g., Brassica varieties) with tolerance to ALS-inhibiting herbicides are provided herein. The methods can include making mutations in the gene encoding acetolactate synthase (ALS)/acetohydroxyacid synthase (AHAS), where the mutations are induced using a rare-cutting endonuclease and a donor matrix.
Abstract translation: 本文提供了具有对ALS抑制性除草剂具有耐受性的植物（例如，芸苔属品种）的材料和方法。 该方法可以包括在编码乙酰乳酸合酶（ALS）/乙酰羟酸合成酶（AHAS）的基因中进行突变，其中使用稀有切割内切核酸酶和供体基质诱导突变。
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公开(公告)号：US20140178561A1
公开(公告)日：2014-06-26
申请号：US14135766
申请日：2013-12-20
Applicant: Cellectis
Inventor： Luc Mathis , Daniel F. Voytas , Feng Zhang , Benjamin Clasen , William Haun , Thomas Stoddard
CPC classification number: C12N15/01 , A23V2002/00 , C12N15/8245
Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
Abstract translation: 提供了材料和方法，用于制造冷藏土豆中还原糖和丙烯酰胺积累减少的植物（例如茄属品种），具体地，通过在编码液泡转化酶的基因中产生TALE-核酸酶诱导的突变。
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公开(公告)号：US11576317B2
公开(公告)日：2023-02-14
申请号：US17098210
申请日：2020-11-13
Applicant: CELLECTIS SA , MEDICAGO INC.
Inventor： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
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