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1.发明授权公开(公告)号：US10472396B2
公开(公告)日：2019-11-12
申请号：US14696920
申请日：2015-04-27
Applicant: CELLECTIS
Inventor： Claudia Bertonati , Philippe Duchateau , Alexandre Juillerat , George Silva , Julien Valton
IPC: C12N9/22 , C12N15/62 , C07K14/195 , A01K67/027 , C12N15/87 , C12N15/90
Abstract: The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
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Patent Agency Ranking
公开(公告)号：US10738289B2
公开(公告)日：2020-08-11
申请号：US15466714
申请日：2017-03-22
Applicant: CELLECTIS S.A.
Inventor： George Silva , Marine Beurdeley
Abstract: The present invention relates to a method to cleave target nucleic acid sequence by the catalytic domain of a GIY-YIG homing endonucleases I-TevI. More precisely, the invention relates to the deciphering of new preferential I-TevI cleavage sites for efficient and specific cleavage activity. The invention concerns a method for the generation of TevI specific chimeric endonucleases to target nucleic acid sequence including such cleavage sites and methods of using same for gene editing.
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3.发明申请NEW MODULAR BASE-SPECIFIC NUCLEIC ACID BINDING DOMAINS FROM BURKHOLDERIA RHIZOXINICA PROTEINS 审中-公开来自BURKHOLDERIA RHIZOXINICA蛋白的新的模块化特异性核酸结合域公开(公告)号：US20150225465A1
公开(公告)日：2015-08-13
申请号：US14696920
申请日：2015-04-27
Applicant: Cellectis
Inventor： Claudia BERTONATI , Philippe Duchateau , Alexandre Juillerat , George Silva , Julien Valton
IPC: C07K14/195 , C12N15/90 , C12N9/22
CPC classification number: C07K14/195 , A01K67/0275 , A01K2217/07 , C07K2319/80 , C12N9/22 , C12N15/62 , C12N15/87 , C12N15/902 , C12N15/907 , C12Y301/21
Abstract: The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
Abstract translation: 本发明涉及从新鉴定的来自细菌内分泌杆菌伯克霍尔德杆菌（Burkholderia Rhizoxinica）的新鉴定的蛋白质中获得的新的基于碱基的碱基特异性核酸结合结构域（MBBBD）及其用于工程化核酸加工酶如特异性内切核酸酶或转录激活子的用途。
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公开(公告)号：US20170260513A1
公开(公告)日：2017-09-14
申请号：US15466714
申请日：2017-03-22
Applicant: CELLECTIS S.A.
Inventor： George Silva , Marine Beurdeley
IPC: C12N9/22 , C07K14/195 , C12N15/82 , C12N15/90
Abstract: The present invention relates to a method to cleave target nucleic acid sequence by the catalytic domain of a GIY-YIG homing endonucleases I-TevI. More precisely, the invention relates to the deciphering of new preferential I-TevI cleavage sites for efficient and specific cleavage activity. The invention concerns a method for the generation of TevI specific chimeric endonucleases to target nucleic acid sequence including such cleavage sites and methods of using same for gene editing.
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5.发明申请TEVI CHIMERIC ENDONUCLEASE AND THEIR PREFERENTIAL CLEAVAGE SITES 审中-公开TEVI CHIMERIC内切酶及其优选CLEAVAGE SITES公开(公告)号：US20150376585A1
公开(公告)日：2015-12-31
申请号：US14764933
申请日：2014-01-29
Applicant: CELLECTIS
Inventor： George Silva , Marine Beurdeley
IPC: C12N9/22 , C12N15/90 , C12N15/82 , C07K14/195
CPC classification number: C12N9/22 , C07K14/195 , C07K2319/80 , C12N15/8213 , C12N15/907
Abstract: The present invention relates to a method to cleave target nucleic acid sequence by the catalytic domain of a GIY-YIG homing endonucleases 1-Tevl. More precisely, the invention relates to the deciphering of new preferential 1-Tevl cleavage sites for efficient and specific cleavage activity. The invention concerns a method for the generation of TevI specific chimeric endonucleases to target nucleic acid sequence including such cleavage sites and methods of using same for gene editing.
Abstract translation: 本发明涉及通过GIY-YIG归巢内切核酸酶1-Tev1的催化结构域切割靶核酸序列的方法。 更准确地说，本发明涉及用于有效和特异性切割活性的新的优先1-脱乙酰裂解位点的解密。 本发明涉及用于产生TevI特异性嵌合核酸内切酶以靶向包括这种切割位点的核酸序列的方法及其用于基因编辑的方法。
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6.发明申请MODULAR BASE-SPECIFIC NUCLEIC ACID BINDING DOMAINS FROM BURKHOLDERIA RHIZOXINICA PROTEINS 审中-公开来自BURKHOLDERIA RHIZOXINICA蛋白的模块化特异性核酸结合域公开(公告)号：US20140230083A1
公开(公告)日：2014-08-14
申请号：US13949880
申请日：2013-07-24
Applicant: CELLECTIS
Inventor： Claudia Bertonati , Philippe Duchateau , Alexandre Juillerat , George Silva , Julien Valton
IPC: C12N15/87 , A01K67/027
CPC classification number: C07K14/195 , A01K67/0275 , A01K2217/07 , C07K2319/80 , C12N9/22 , C12N15/62 , C12N15/87 , C12N15/902 , C12N15/907 , C12Y301/21
Abstract: The present invention concerns new modular base-per-base specific nucleic acid binding domains (MBBBD) derived from newly identified proteins from the bacterial endosymbiont Burkholderia Rhizoxinica and their use for engineering nucleic acid processing enzymes, such as specific endonucleases or transcription activators.
Abstract translation: 本发明涉及从新鉴定的来自细菌内分泌杆菌伯克霍尔德杆菌（Burkholderia Rhizoxinica）的新鉴定的蛋白质中获得的新的基于碱基的碱基特异性核酸结合结构域（MBBBD）及其用于工程化核酸加工酶如特异性内切核酸酶或转录激活子的用途。
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