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公开(公告)号：US20190062321A1
公开(公告)日：2019-02-28
申请号：US16049482
申请日：2018-07-30
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC: C07D417/04 , C07D275/04 , C07D231/56 , C07C259/08 , C07D277/60 , C07D231/54 , C07D239/74 , C07D239/70 , C07D403/04 , C07D401/04 , C07D239/88
CPC classification number: C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use.
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公开(公告)号：US10457675B2
公开(公告)日：2019-10-29
申请号：US16049482
申请日：2018-07-30
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC: C07D417/04 , C07D231/54 , C07D401/04 , C07D403/04 , C07D239/70 , C07D239/74 , C07D239/88 , C07D277/60 , C07C259/08 , C07D231/56 , C07D275/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use.
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公开(公告)号：US20160031876A1
公开(公告)日：2016-02-04
申请号：US14776320
申请日：2014-03-10
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC: C07D471/04 , C07D213/56 , C07D241/12 , C07D239/26 , C07D213/61 , C07D333/60 , C07D231/12 , C07D261/20 , C07D213/64 , C07D275/04 , C07D277/64 , C07C259/08 , C07D241/42
CPC classification number: C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US11685734B2
公开(公告)日：2023-06-27
申请号：US17111307
申请日：2020-12-03
Applicant: CHDI Foundation, Inc.
Inventor： Leticia M. Toledo-Sherman , Celia Dominguez , Perla Breccia , Amanda J. Van De Poël , Grant Wishart , Huw D. Vater , William R. K. Esmieu , Cole Clissold , Wesley P. Blackaby
IPC: C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/55 , A61K31/5377 , A61K31/505 , A61P21/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P27/02
CPC classification number: C07D413/14 , C07D401/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04
Abstract: Provided are certain ATM kinase inhibitors of Formula I:
Also provided herein are compositions of such compounds, and methods of their use.-
公开(公告)号：US10065948B2
公开(公告)日：2018-09-04
申请号：US15315713
申请日：2015-06-01
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Roland W. Bürli , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebecca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC: C07D417/04 , C07D231/54 , C07D401/04 , C07D403/04 , C07D231/56 , C07D239/88 , C07D277/60 , C07D239/70 , C07C259/08
CPC classification number: C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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Patent Agency Ranking
公开(公告)号：US20170305900A1
公开(公告)日：2017-10-26
申请号：US15482327
申请日：2017-04-07
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC: C07D471/04 , C07D277/64 , C07C259/08 , C07D277/62 , C07D275/04 , C07D261/20 , C07D241/42 , C07D241/12 , C07D239/26 , C07D231/56 , C07D231/12 , C07D213/64 , C07D213/61 , C07D213/56 , C07D333/60 , C07C2601/02 , C07C2601/10
CPC classification number: C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US20220409615A1
公开(公告)日：2022-12-29
申请号：US17318693
申请日：2021-05-12
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Elizabeth M. Doherty , Longbin Liu , Matthew Lee , Mark Stuart Chambers , Karine Fabienne Malagu , Perla Breccia , Alan F. Haughan , Huw D. Vater , Andrew J. Stott , William R. K. Esmieu , Stephen John Webster , Amanda J. Van De Poël
IPC: A61K31/497 , C07D471/04 , C07D519/00 , A61K31/4985 , C07D487/04 , C07D403/14 , A61K31/506 , A61K31/501 , C07D413/14 , A61P25/28
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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公开(公告)号：US20170101402A1
公开(公告)日：2017-04-13
申请号：US15315713
申请日：2015-06-01
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Christopher A. Luckhurst , Daniel R. Allen , Gilles Raphy , Roland W. Bürli , Perla Breccia , Alan F. Haughan , Grant Wishart , Samantha J. Hughes , Rebeca E. Jarvis , Huw D. Vater , Stephen D. Penrose , Michael Wall , Andrew J. Stott , Elizabeth A. Saville-Stones
IPC: C07D417/04 , C07D401/04 , C07D403/04 , C07C259/08 , C07D239/88 , C07D277/60 , C07D239/70 , C07D231/54 , C07D231/56
CPC classification number: C07D417/04 , C07C259/08 , C07D231/54 , C07D231/56 , C07D239/70 , C07D239/74 , C07D239/88 , C07D275/04 , C07D277/60 , C07D401/04 , C07D403/04
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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公开(公告)号：US09617259B2
公开(公告)日：2017-04-11
申请号：US14776320
申请日：2014-03-10
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Ignacio Muñoz-Sanjuán , Michel Maillard , Christopher A. Luckhurst , Rebecca E. Jarvis , Roland W. Bürli , Daniel R. Allen , Alan F. Haughan , Perla Breccia , Huw D. Vater , Andrew J. Stott , Stephen D. Penrose , Michael Wall , Elizabeth A. Saville-Stones , Grant Wishart , Samantha J. Hughes
IPC: C07D471/04 , C07D277/64 , C07D241/12 , C07D213/64 , C07C259/08 , C07D277/62 , C07D261/20 , C07D275/04 , C07D333/60 , C07D213/56 , C07D213/61 , C07D239/26 , C07D241/42 , C07D231/12 , C07D231/56
CPC classification number: C07D471/04 , C07C259/08 , C07C2601/02 , C07C2601/10 , C07D213/56 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/56 , C07D239/26 , C07D241/12 , C07D241/42 , C07D261/20 , C07D275/04 , C07D277/62 , C07D277/64 , C07D333/60
Abstract: Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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公开(公告)号：US11806346B2
公开(公告)日：2023-11-07
申请号：US17318693
申请日：2021-05-12
Applicant: CHDI Foundation, Inc.
Inventor： Celia Dominguez , Elizabeth M. Doherty , Longbin Liu , Matthew Lee , Mark Stuart Chambers , Karine Fabienne Malagu , Perla Breccia , Alan F. Haughan , Huw D. Vater , Andrew J. Stott , William R. K. Esmieu , Stephen John Webster , Amanda J. Van De Poël
IPC: A61K31/497 , A61P25/28 , A61K31/4985 , A61K31/501 , A61K31/506 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
CPC classification number: A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61P25/28 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D519/00
Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.
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