公开(公告)号：US09199980B2

公开(公告)日：2015-12-01

申请号：US14097586

申请日：2013-12-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Mauro Riccaboni ,  Andrea Rizzi ,  Charles Baker-Glenn ,  Wesley Blackaby ,  Herve′ Van de Poel ,  Ben Whittaker

IPC: A61K31/44 ,  A61K9/14 ,  C07D453/02 ,  C07D421/00 ,  C07D401/14 ,  C07D401/12 ,  C07D453/00 ,  A61K31/439 ,  A61K9/00

CPC classification number: C07D453/02 ,  A61K9/0075 ,  A61K31/439 ,  C07D401/12 ,  C07D401/14 ,  C07D453/00

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US20140155427A1

公开(公告)日：2014-06-05

申请号：US14097586

申请日：2013-12-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Gabriele Amari ,  Mauro Riccaboni ,  Andrea Rizzi ,  Charles Baker-Glenn ,  Wesley Blackaby ,  Herve' Van de Poel ,  Ben Whittaker

IPC: C07D453/02 ,  A61K31/444

CPC classification number: C07D453/02 ,  A61K9/0075 ,  A61K31/439 ,  C07D401/12 ,  C07D401/14 ,  C07D453/00

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US10087176B2

公开(公告)日：2018-10-02

申请号：US15316401

申请日：2014-06-04

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele Amari ,  Elisabetta Armani ,  Mauro Riccaboni ,  Andrea Rizzi ,  Charles Baker-Glenn ,  Wesley Blackaby ,  Herve Van De Poel ,  Ben Whittaker

IPC: C07D453/02

Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

公开(公告)号：US09133185B2

公开(公告)日：2015-09-15

申请号：US14560140

申请日：2014-12-04

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele Amari ,  Elisabetta Armani ,  Eleonora Ghidini ,  Charles Baker-Glenn ,  Hervé Van De Poël ,  Ben Whittaker

IPC: C07D453/02 ,  C07D409/14 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4436 ,  A61K31/44 ,  A61M16/14 ,  A61M15/00

CPC classification number: C07D453/02 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61M15/0065 ,  A61M16/14 ,  A61M2202/064 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。