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公开(公告)号：US09199980B2
公开(公告)日：2015-12-01
申请号：US14097586
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve′ Van de Poel , Ben Whittaker
IPC: A61K31/44 , A61K9/14 , C07D453/02 , C07D421/00 , C07D401/14 , C07D401/12 , C07D453/00 , A61K31/439 , A61K9/00
CPC classification number: C07D453/02 , A61K9/0075 , A61K31/439 , C07D401/12 , C07D401/14 , C07D453/00
Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US08835682B2
公开(公告)日：2014-09-16
申请号：US13827101
申请日：2013-03-14
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Antonio Caligiuri , Mauro Riccaboni , Gabriele Amari
IPC: C07C229/00 , C07C233/80 , C07D453/02 , C07D211/46 , C07D333/24 , C07D223/08 , C07D491/08 , C07D451/10 , C07D211/44 , C07D209/02 , C07D207/12 , C07D211/42
CPC classification number: C07D453/02 , C07C233/80 , C07D207/12 , C07D209/02 , C07D211/42 , C07D211/44 , C07D211/46 , C07D223/08 , C07D333/24 , C07D451/10 , C07D491/08
Abstract: Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.
Abstract translation: 作为毒蕈碱受体拮抗剂的生物碱类氨基酯化合物可用于预防和/或治疗支气管阻塞性或炎性疾病。
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公开(公告)号：US20140155428A1
公开(公告)日：2014-06-05
申请号：US14097693
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A
Inventor： Elisabetta ARMANI , Gabriele Amari , Mauro Riccaboni , Charles Baker-Glenn
IPC: C07D453/02 , A61K31/444
CPC classification number: C07D453/02 , A61K45/06 , C07D401/12 , C07D453/00
Abstract: Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文定义的式（I）化合物既是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US09890151B2
公开(公告)日：2018-02-13
申请号：US15316312
申请日：2014-06-04
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Gabriele Amari , Elisabetta Armani , Mauro Riccaboni , Charles Baker-Glenn
IPC: C07D453/02 , A61K31/444 , A61K9/00
CPC classification number: C07D453/02 , A61K9/0073 , A61K31/444 , C07D453/00
Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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公开(公告)号：US09145409B2
公开(公告)日：2015-09-29
申请号：US14560009
申请日：2014-12-04
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Gabriele Amari , Elisabetta Armani , Carmelida Capaldi , Renato De Fanti , Mauro Riccaboni , Charles Baker-Glenn , Hervé Van De Poël
IPC: C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496
CPC classification number: C07D453/02 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Compounds having a benzhydryl structure represented by formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
Abstract translation: 具有本文所述的式（I）表示的二苯甲基结构的化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于治疗呼吸道疾病。
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Patent Agency Ranking
公开(公告)号：US20140155427A1
公开(公告)日：2014-06-05
申请号：US14097586
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve' Van de Poel , Ben Whittaker
IPC: C07D453/02 , A61K31/444
CPC classification number: C07D453/02 , A61K9/0075 , A61K31/439 , C07D401/12 , C07D401/14 , C07D453/00
Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20140155373A1
公开(公告)日：2014-06-05
申请号：US14097397
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Charles Baker-Glenn
IPC: C07D453/02 , A61K31/4545 , A61K31/444
CPC classification number: C07D453/02 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D453/00
Abstract: Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20130196978A1
公开(公告)日：2013-08-01
申请号：US13827101
申请日：2013-03-14
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Antonio CALIGIURI , Mauro Riccaboni , Gabriele Amari
IPC: C07D453/02 , C07D207/12 , C07D223/08 , C07D491/08 , C07C233/80 , C07D333/24 , C07D211/44 , C07D209/02
CPC classification number: C07D453/02 , C07C233/80 , C07D207/12 , C07D209/02 , C07D211/42 , C07D211/44 , C07D211/46 , C07D223/08 , C07D333/24 , C07D451/10 , C07D491/08
Abstract: Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.
Abstract translation: 作为毒蕈碱受体拮抗剂的生物碱类氨基酯化合物可用于预防和/或治疗支气管阻塞性或炎性疾病。
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公开(公告)号：US10087176B2
公开(公告)日：2018-10-02
申请号：US15316401
申请日：2014-06-04
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Gabriele Amari , Elisabetta Armani , Mauro Riccaboni , Andrea Rizzi , Charles Baker-Glenn , Wesley Blackaby , Herve Van De Poel , Ben Whittaker
IPC: C07D453/02
Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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公开(公告)号：US09169245B2
公开(公告)日：2015-10-27
申请号：US14097397
申请日：2013-12-05
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Elisabetta Armani , Gabriele Amari , Mauro Riccaboni , Charles Baker-Glenn
IPC: C07D453/02 , C07D453/00 , C07D401/14 , C07D401/12 , C07D417/14 , C07D417/12 , A61K31/444 , A61K31/4427 , A61M15/00 , A61P11/00 , A61P11/06
CPC classification number: C07D453/02 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D453/00
Abstract: Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶和毒蕈碱M3受体拮抗剂的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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