公开(公告)号：US11339110B2

公开(公告)日：2022-05-24

申请号：US16720711

申请日：2019-12-19

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng ,  Ming-Kun Hsu ,  Min-Kuan Hsu ,  Tzyh-Mann Wei

IPC: C07C59/72 ,  C07C51/43

Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.

公开(公告)号：US11332433B2

公开(公告)日：2022-05-17

申请号：US16938238

申请日：2020-07-24

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Ming-Kun Hsu ,  Tzyh-Mann Wei

IPC: C07C201/02 ,  C07C203/04 ,  C07C69/732 ,  C07F7/02 ,  A61K31/216

Abstract: Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.