公开(公告)号：US10787416B1

公开(公告)日：2020-09-29

申请号：US16868624

申请日：2020-05-07

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07C255/37

Abstract: Stable crystalline Form I and Form II of compound (I) and methods for preparation thereof are provided, which present advantages in storage, formulation, shipment and handling for commercial considerations.

公开(公告)号：US11339110B2

公开(公告)日：2022-05-24

申请号：US16720711

申请日：2019-12-19

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng ,  Ming-Kun Hsu ,  Min-Kuan Hsu ,  Tzyh-Mann Wei

IPC: C07C59/72 ,  C07C51/43

Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.

公开(公告)号：US10577340B1

公开(公告)日：2020-03-03

申请号：US16199443

申请日：2018-11-26

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07D307/79

Abstract: The present invention provides crystalline Forms II and III of Beraprost-314d, and processes for the preparation thereof.

公开(公告)号：US10781160B1

公开(公告)日：2020-09-22

申请号：US16592835

申请日：2019-10-04

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07C69/736 ,  C07C67/52

Abstract: There is provided stable crystalline Form I and Form II of Hexadecyl Treprostinil (C16TR) and processes for the preparation thereof. The stable crystalline Form I and Form II of Hexadecyl Treprostinil present advantages in storage, formulation, shipment and handling for commercially considerations.

公开(公告)号：US11447440B2

公开(公告)日：2022-09-20

申请号：US17083673

申请日：2020-10-29

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng ,  Chun Hsieh

IPC: C07C59/13 ,  C07C51/43 ,  C07C51/47

Abstract: Novel crystalline forms of Treprostinil monohydrate, a mixture including the same, and preparation methods thereof.

公开(公告)号：US10577341B1

公开(公告)日：2020-03-03

申请号：US16199471

申请日：2018-11-26

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: C07D307/93

Abstract: The present invention provides a monohydrated form of Beraprost-314d, and a novel crystalline form of Beraprost-314d monohydrate, and processes for the preparation thereof.

公开(公告)号：US10253011B1

公开(公告)日：2019-04-09

申请号：US16034686

申请日：2018-07-13

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Jian-Bang Jheng

IPC: B01D9/00 ,  C07D311/94

Abstract: This present invention relates to novel Lubiprostone crystals and methods for preparing the same. The preparation methods provided by the invention can effectively reduce or eliminate impurity in the obtained Lubiprostone crystals.