公开(公告)号：US20170367953A1

公开(公告)日：2017-12-28

申请号：US15629097

申请日：2017-06-21

Applicant: Colgate-Palmolive Company

Inventor： Dandan Chen ,  Ying YANG ,  Robert D'AMBROGIO ,  Paul THOMSON ,  Harsh Mahendra TRIVEDI ,  Michael PRENCIPE ,  James MASTERS ,  Stanislav JARACZ

IPC: A61K8/34 ,  A61K8/25 ,  A61K8/21 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/35

CPC classification number: A61K8/347 ,  A61K8/19 ,  A61K8/21 ,  A61K8/25 ,  A61K8/27 ,  A61K8/35 ,  A61K2800/48 ,  A61Q11/00

Abstract: This invention relates to oral care compositions comprising zingerone, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.

公开(公告)号：US20220146512A1

公开(公告)日：2022-05-12

申请号：US17309892

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille ZENOBIA ,  Harsh Mahendra TRIVEDI ,  Ying YANG

IPC: G01N33/569 ,  G01N33/50 ,  G01N33/68

Abstract: Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, M1F:CXCL1; MIF:CXCL5; MIF:CXCL8; M1F:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.

公开(公告)号：US20220091101A1

公开(公告)日：2022-03-24

申请号：US17309896

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Camille ZENOBIA ,  Harsh TRIVEDI ,  Ying YANG ,  Carlo DAEP ,  James MASTERS

IPC: G01N33/50 ,  C12N1/20 ,  G09B23/30

Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.

公开(公告)号：US20200206108A1

公开(公告)日：2020-07-02

申请号：US16715325

申请日：2019-12-16

Applicant: Colgate-Palmolive Company

Inventor： Carlo DAEP ,  Ekta MAKWANA ,  Lynette ZAIDEL ,  Ying YANG ,  Harsh Mahendra TRIVEDI

IPC: A61K8/27 ,  A61K8/44 ,  A61Q11/00

Abstract: The present disclosure relates to oral care compositions providing oral and/or systemic benefits. In some embodiments, the oral care compositions of the present disclosure comprise arginine or a salt thereof, and one or more zinc ion sources (e.g., zinc oxide and zinc citrate), as well as to methods of making these compositions.

公开(公告)号：US20190167555A1

公开(公告)日：2019-06-06

申请号：US15828511

申请日：2017-12-01

Applicant: Colgate-Palmolive Company

Inventor： Shao Peng XU ,  Peng YAN ,  Ying YANG

IPC: A61K8/63 ,  A61K8/34 ,  A61Q11/00

Abstract: Oral care compositions including a hemostatic agent, wherein the hemostatic agent includes a mixture of oleanic acid and eugenol. Methods of making and using these compositions are also described.

公开(公告)号：US20160296437A1

公开(公告)日：2016-10-13

申请号：US15100990

申请日：2013-12-02

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Ying YANG ,  Harsh M. TRIVEDI ,  Guofeng XU

IPC: A61K8/27 ,  A61Q11/00

CPC classification number: A61K8/27 ,  A61K8/365 ,  A61Q11/00

Abstract: A composition comprising a zinc ion source for use in inhibiting the adherence to or invasion of oral soft tissue, such as gingival epithelial cells, by a periodontal pathogen is provided.

Abstract translation: 提供了包含用于通过牙周病原体抑制口腔软组织如牙龈上皮细胞的粘附或侵入的锌离子源的组合物。

公开(公告)号：US20250041196A1

公开(公告)日：2025-02-06

申请号：US18717936

申请日：2022-12-07

Applicant: Colgate-Palmolive Company

Inventor： Yuzhi DENG ,  Dandan CHEN ,  Diana Liceth HENAO ADLEVANKIN ,  Joseph Allan McKinnon STEELE ,  Julia Maighdlin DUGDALE ,  Paul THOMSON ,  Payal ARORA ,  Manisha JHA ,  Lisa Marie MANUS ,  Ying YANG

IPC: A61K8/73 ,  A61K8/34 ,  A61K8/46 ,  A61K8/49 ,  A61K8/67 ,  A61Q11/00

Abstract: Oral care compositions and methods for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof are disclosed. Oral care compositions for improving oral care by treating, preventing, or otherwise inhibiting discomfort, irritation, or gum pain of the oral cavity are also disclosed. The oral care composition may include an orally acceptable vehicle, hyaluronic acid, and one or more benefit agents. The method for treating, preventing, or inhibiting dry mouth and/or inflammation of the oral cavity or a surface thereof may include contacting the oral cavity or the surface thereof with the oral care compositions.

公开(公告)号：US20240050344A1

公开(公告)日：2024-02-15

申请号：US18549085

申请日：2021-03-11

Applicant: Colgate-Palmolive Company

Inventor： Ying YANG ,  Shaopeng XU ,  Guofeng XU ,  Harsh Mahendra TRIVEDI ,  James MASTERS ,  Dandan CHEN ,  Betty WON

IPC: A61K8/44 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/21

CPC classification number: A61K8/44 ,  A61K8/27 ,  A61Q11/00 ,  A61K8/21 ,  A61K2800/92

Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of β-Defensin 1 in the individual's oral cavity are disclosed.

公开(公告)号：US20200206106A1

公开(公告)日：2020-07-02

申请号：US16717821

申请日：2019-12-17

Applicant: Colgate-Palmolive Company

Inventor： Dandan CHEN ,  Harsh Mahendra TRIVEDI ,  Ying YANG ,  James MASTERS

IPC: A61K8/24 ,  A61Q11/00 ,  A61K8/21 ,  A61K8/25 ,  A61K8/04 ,  A61K8/02 ,  A61K8/365 ,  A61K8/27

Abstract: Methods of increasing sIgA and mucin 5B levels in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity in an amount effective to increase sIgA and mucin 5B levels in the individual's oral cavity, an oral care composition comprising: zinc phosphate, stannous fluoride and optionally, an organic acid buffer system.

公开(公告)号：US20190275355A1

公开(公告)日：2019-09-12

申请号：US16425312

申请日：2019-05-29

Applicant: Colgate-Palmolive Company

Inventor： Ying YANG ,  Dandan CHEN ,  Robert D'AMBROGIO ,  Paul THOMSON ,  Harsh Mahendra TRIVEDI ,  Michael PRENCIPE ,  James MASTERS ,  Stanislav JARACZ

IPC: A61Q11/00 ,  A61K8/21 ,  A61Q17/00 ,  A61K8/365 ,  A61K8/35 ,  A61K8/34 ,  A61K8/22 ,  A61K36/9068 ,  A61K8/97 ,  A61K8/27 ,  A61K45/06

Abstract: This invention relates to oral care compositions comprising zingerone, bisabolol, a stannous ion source, zinc oxide, and zinc citrate, as well as to methods of using and of making these compositions.