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公开(公告)号：US12117441B2
公开(公告)日：2024-10-15
申请号：US16668005
申请日：2019-10-30
发明人： Francisco Javier Tamayo De Miguel , Priscila Monteiro Kosaka , Valerio Pini , Montserrat Calleja Goméz , Jose Jaime Ruz Martinez , Daniel Ramos Vega , Maria Ujue Gonzalez Sagardoy
IPC分类号： G01N33/53 , G01N21/47 , G01N21/552 , G01N21/59 , G01N21/65 , G01N21/77 , G01N33/543
CPC分类号： G01N33/54346 , G01N21/47 , G01N21/554 , G01N21/59 , G01N21/658 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/5903
摘要： The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.
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公开(公告)号：US10670447B2
公开(公告)日：2020-06-02
申请号：US16093088
申请日：2017-02-22
发明人： Oscar Malvar Vidal , Jose Jaime Ruz Martinez , Priscila Monteiro Kosaka , Montserrat Calleja Gomez , Francisco Javier Tamayo De Miguel
摘要： A method for obtaining the absorption position, mass and rigidity of a particle deposited on the surface of a resonator based on the relative change in the resonance frequency of said resonator in 3 or 4 flexural vibration modes. The rigidity of the particles is of great interest in the study of cells and other biological compounds that change state without significantly changing the mass.
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公开(公告)号：US20190162580A1
公开(公告)日：2019-05-30
申请号：US16093088
申请日：2017-02-22
发明人： Oscar Malvar Vidal , Jose Jaime Ruz Martinez , Priscila Monteiro Kosaka , Montserrat Calleja Gomez , Francisco Javier Tamayo De Miguel
摘要： A method for obtaining the absorption position, mass and rigidity of a particle deposited on the surface of a resonator based on the relative change in the resonance frequency of said resonator in 3 or 4 flexural vibration modes. The rigidity of the particles is of great interest in the study of cells and other biological compounds that change state without significantly changing the mass.
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公开(公告)号：US09829427B2
公开(公告)日：2017-11-28
申请号：US14406007
申请日：2013-05-23
发明人： Francisco Javier Tamayo De Miguel , Valerio Pini , Priscila Monteiro Kosaka , Montserrat Calleja Gomez , Sheila Gonzalez Castilla
CPC分类号： G01N21/1702 , B81C99/003 , B82B3/0085 , G01B21/20 , G01H9/00 , G01N2201/06113 , G01Q10/06 , G01Q20/02
摘要： Method and system in optical microscopy based on the deflection of micro- and nanomechanical structures, upon impact of a laser beam thereon, which simultaneously and automatically provides a spatial map of the static deflection and of the form of various vibration modes, with vertical resolution in the subangstrom range. The invention comprises at least one mechanical structure, an incident laser beam sweeping the surface of the structure, an optometric detector for capturing the laser beam, and frequency excitation means that generate at least two sinusoidal signals at different frequencies in the mechanical structure.
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公开(公告)号：US10281330B2
公开(公告)日：2019-05-07
申请号：US15517809
申请日：2015-10-08
发明人： Valerio Pini , Priscila Monteiro Kosaka , Francisco Javier Tamayo De Miguel , Montserrat Calleja Gomez , Daniel Ramos Vega , Oscar Malvar Vidal , Jose Jaime Ruz Martinez , Mario Encinar Del Pozo
摘要： The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (4), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (5), said processing means having a correlation wherein each of the photodetectors (5) corresponds to a spatial point on the sample (4).In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.
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6.发明申请METHOD AND SYSTEM FOR CHARACTERIZATION OF NANO- AND MICROMECHANICAL STRUCTURES 有权用于表征纳米和微结构结构的方法和系统公开(公告)号：US20150177126A1
公开(公告)日：2015-06-25
申请号：US14406007
申请日：2013-05-23
发明人： Francisco Javier Tamayo De Miguel , Valerio Pini , Priscila Monteiro Kosaka , Montserrat Calleja Gomez , Sheila Gonzalez Castilla
CPC分类号： G01N21/1702 , B81C99/003 , B82B3/0085 , G01B21/20 , G01H9/00 , G01N2201/06113 , G01Q10/06 , G01Q20/02
摘要： Method and system in optical microscopy based on the deflection of micro- and nanomechanical structures, upon impact of a laser beam theron, which simultaneously and automatically provides a spatial map of the static deflection and of the form of various vibration modes, with vertical resolution in the subangstrom range. The invention comprises at least one mechanical structure, an incident laser beam sweeping the surface of the structure, an optometric detector for capturing the laser beam, and frequency excitation means that generate at least two sinusoidal signals at different frequencies in the mechanical structure.
摘要翻译： 基于微型和纳米机械结构的偏转的光学显微镜的方法和系统，在激光束的同时自动提供静态偏转和各种振动模式的形式的空间图，垂直分辨率 超声波范围。 本发明包括至少一个机械结构，扫描结构表面的入射激光束，用于捕获激光束的验光检测器和在机械结构中产生不同频率的至少两个正弦信号的频率激励装置。
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