CONTAINER CLOSURE SYSTEM AND SEALING ASSEMBLIES FOR MAINTAINING SEAL INTEGRITY AT LOW STORAGE TEMPERATURES

    公开(公告)号:US20220339067A1

    公开(公告)日:2022-10-27

    申请号:US17728337

    申请日:2022-04-25

    Abstract: A sealed pharmaceutical container comprises a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange comprises an outer surface extending from the underside surface and a contact surface extending between the outer surface and an inner surface defining an opening in the sealed pharmaceutical container. The contact surface comprises an outer peripheral edge disposed proximate to the outer surface of the flange. The sealed pharmaceutical container comprises a sealing assembly comprising a stopper extending over the contact surface of the flange and covering the opening, and a cap securing the stopper to the flange. The stopper comprises a sealing surface that is secured in contact with the contact surface of the flange to form a seal between the flange and the stopper. An outer peripheral edge of the sealing surface is disposed at or radially inward of the outer peripheral edge.

    Cap design for pharmaceutical container closure systems

    公开(公告)号:US12090118B2

    公开(公告)日:2024-09-17

    申请号:US17992412

    申请日:2022-11-22

    CPC classification number: A61J1/1412 A61J1/065 A61J1/1468 B65B7/2821 B65D41/28

    Abstract: Caps for sealing assemblies for sealing glass containers and maintaining container closure integrity at −80° C. or less are disclosed. The caps include a cap skirt having an annular body and a crimp region. The crimp region is a crimpable metal. The annular body of the cap skirt has a coefficient of thermal expansion (CTE) greater than a CTE of a metal consisting of aluminum, a stiffness greater than or equal to 2 times a stiffness of the crimp region, or both. The greater CTE, stiffness, or both of the cap skirt increase the seal pressure and contact area between the stopper and glass container when cooled to −80° C. or less. The caps enable the sealing assemblies to maintain a helium leakage rate of the sealed glass container of less than or equal to 1.4×10−6 cm3/s at −80° C. or less.

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