公开(公告)号：US20230151320A1

公开(公告)日：2023-05-18

申请号：US18099597

申请日：2023-01-20

Applicant: CORNING INCORPORATED

Inventor： Scott Robertson Bickham ,  Ming-Jun Li ,  Gregory Roger Martin ,  Robert Raymond Raczkowski ,  Horst Schreiber ,  Todd Michael Upton

IPC: C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  G01N21/65

CPC classification number: C12M41/14 ,  C12M33/04 ,  C12M41/48 ,  C12M43/00 ,  G01N21/65 ,  C12M37/06

Abstract: Methods, systems, and devices for non-invasive measurement of cell cultures are described that provide for remote monitoring of cell status. The system includes a cell culture vessel, at least one monitoring layer, at least one measurement device, and a communication component. The cell culture vessel may include at least one cell culture chamber configured for cell growth and for closed-system operation. The monitoring layer is external to the at least one cell culture chamber. In some cases, the communication component is configured to transmit data from the monitoring layer to a remote location.

公开(公告)号：US11768194B2

公开(公告)日：2023-09-26

申请号：US17564465

申请日：2021-12-29

Applicant: CORNING INCORPORATED

Inventor： Joshua Monroe Cobb ,  Gregory Roger Martin ,  Robert Raymond Raczkowski ,  Mark Christian Sanson ,  Horst Schreiber ,  Todd Michael Upton

IPC: C12M1/32 ,  C12M1/34 ,  G02B21/00 ,  G02B21/04 ,  G02B21/36 ,  G01N21/55 ,  G01N33/483 ,  G01N33/50

CPC classification number: G01N33/4833 ,  C12M23/12 ,  C12M41/46 ,  G01N21/55 ,  G01N33/5005 ,  G02B21/361 ,  G02B21/002 ,  G02B21/04 ,  G02B21/36

Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.

公开(公告)号：US20220120729A1

公开(公告)日：2022-04-21

申请号：US17564465

申请日：2021-12-29

Applicant: CORNING INCORPORATED

Inventor： Joshua Monroe Cobb ,  Gregory Roger Martin ,  Robert Raymond Raczkowski ,  Mark Christian Sanson ,  Horst Schreiber ,  Todd Michael Upton

IPC: G01N33/483 ,  C12M1/34 ,  G01N21/55 ,  G02B21/36 ,  C12M1/32 ,  G01N33/50

Abstract: A cell monitoring plate comprises a flat surface on which multiple cell culturing vessels may be stacked. The flats surface has multiple optical imaging systems embedded therein to fully image a cell culture vessels stacked on the plate. Each one of the multiple optical imaging systems provides both illumination and imaging through a single aperture in the surface of the monitoring plate.