公开(公告)号：US12268617B2

公开(公告)日：2025-04-08

申请号：US18581322

申请日：2024-02-19

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20220160942A1

公开(公告)日：2022-05-26

申请号：US17100360

申请日：2020-11-20

Applicant: Covidien LP

Inventor： Peter Skujins ,  Brad L. Jackson ,  Xiaodong Ma

IPC: A61M1/00 ,  A61B17/22

Abstract: In some examples, a medical aspiration system includes a vacuum source; a vacuum tube coupled to the vacuum source; a vent tube; and a device configured to convert a constant suction force from the vacuum source into a periodic suction force, the device including a housing configured to receive a portion of the vacuum tube and a portion of the vent tube; a first plunger; a second plunger; and a rotatable cam configured to cause the first plunger to periodically compress the vacuum tube and to cause the second plunger to periodically compress the vent tube.

公开(公告)号：US20210068991A1

公开(公告)日：2021-03-11

申请号：US17099391

申请日：2020-11-16

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20170296466A1

公开(公告)日：2017-10-19

申请号：US15602940

申请日：2017-05-23

Applicant: Covidien LP

Inventor： Gaurav Girdhar ,  Xiaodong Ma ,  Jennifer Makridakis

IPC: A61K9/00 ,  A61K47/10 ,  A61K31/734 ,  A61K47/14 ,  A61K31/722

CPC classification number: A61K9/0024 ,  A61K31/722 ,  A61K31/734 ,  A61K47/10 ,  A61K47/14 ,  A61K47/36 ,  A61K2300/00

Abstract: An injectable non-aqueous composition and a method of treating a vascular disease, the non-aqueous composition including: chitosan having a particle size of no greater than 50 μm; alginate having a particle size of no greater than 50 μm; and a non-aqueous carrier; wherein upon combination and injection into the vascular system of a subject, the composition causes a diseased portion of the vascular system to be absorbed into surrounding tissue.

公开(公告)号：US20230036800A1

公开(公告)日：2023-02-02

申请号：US17818585

申请日：2022-08-09

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US11369497B2

公开(公告)日：2022-06-28

申请号：US16586639

申请日：2019-09-27

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61M60/165 ,  A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20190125555A1

公开(公告)日：2019-05-02

申请号：US16173879

申请日：2018-10-29

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61F2/06 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61L31/02 ,  A61L33/06 ,  A61L31/14 ,  A61L33/00

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US09655842B1

公开(公告)日：2017-05-23

申请号：US14959446

申请日：2015-12-04

Applicant: Covidien LP

Inventor： Gaurav Girdhar ,  Xiaodong Ma

IPC: A61K9/00 ,  A61K31/734 ,  A61K31/722 ,  A61K47/14 ,  A61K47/10

CPC classification number: A61K9/0024 ,  A61K31/722 ,  A61K31/734 ,  A61K47/10 ,  A61K47/14 ,  A61K47/36 ,  A61K2300/00

Abstract: An injectable non-aqueous composition and a method of treating a vascular disease, the non-aqueous composition including: chitosan having a particle size of no greater than 50 μm; alginate having a particle size of no greater than 50 μm; and a non-aqueous carrier; wherein upon combination and injection into the vascular system of a subject, the chitosan and alginate form a polyelectrolyte gel in situ.

公开(公告)号：US20150140344A1

公开(公告)日：2015-05-21

申请号：US14085127

申请日：2013-11-20

Applicant: COVIDIEN LP

Inventor： Xiaodong Ma ,  Junwei Li ,  Min-Shyan Sheu ,  Anastasia Righter ,  Ariana Gilmore

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L29/085 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2400/18 ,  Y10T428/31663

Abstract: Processes for coating medical devices are provided herein. The processes include contacting a substrate with a sulfur-functional silane and an additional silane. The resulting coating includes a silane layer having improved adherence to the medical device, covering a greater area.

Abstract translation: 本文提供了涂敷医疗器械的方法。 该方法包括使底物与硫官能硅烷和另外的硅烷接触。 所得到的涂层包括具有改进的对医疗装置的附着力的硅烷层，覆盖更大的面积。

公开(公告)号：US20140277400A1

公开(公告)日：2014-09-18

申请号：US13844577

申请日：2013-03-15

Applicant: COVIDIEN LP

Inventor： John Wainwright ,  Todd Mendelson ,  Kurt Haggstrom ,  Xiaodong Ma ,  Masoud Molaei ,  John Muri ,  Anastasia Righter ,  Victoria Schuman ,  Min-Shyan Sheu

IPC: A61F2/07

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/072 ,  A61F2002/823 ,  A61F2250/0067

Abstract: Coating methods and related devices are provided. Such devices can include stents. For example, the device can comprise a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can also comprise an anti-thrombogenic coating distributed over at least a portion of the device such that the pores are substantially free of webs formed by the coating.

Abstract translation: 提供涂布方法和相关设备。 这样的装置可以包括支架。 例如，该装置可以包括侧壁和侧壁中的多个孔，其尺寸被设计成当管状构件定位时防止血液通过侧壁流入动脉瘤至足以导致动脉瘤血栓形成和愈合的程度 在血管中并且与动脉瘤相邻。 该装置还可以包含分布在装置的至少一部分上的抗血栓形成的涂层，使得孔基本上不含由涂层形成的网。