公开(公告)号：US11406514B2

公开(公告)日：2022-08-09

申请号：US17099391

申请日：2020-11-16

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20190350965A1

公开(公告)日：2019-11-21

申请号：US16527740

申请日：2019-07-31

Applicant: Covidien LP

Inventor： Rachit Ohri ,  Phillip D. Blaskovich ,  Min-Shyan Sheu ,  Petra Brockfeld

IPC: A61K31/717 ,  A61K33/20 ,  A61L26/00 ,  A61K31/714 ,  A61K49/04 ,  A61K31/295 ,  A61K33/24 ,  A61K31/445

Abstract: A method of treatment includes agitating a thixotropic oxidized cellulose solution; administering the agitated thixotropic oxidized cellulose solution to a target tissue site; and allowing the agitated thixotropic oxidized cellulose solution to gel at the target tissue site.

公开(公告)号：US09668890B2

公开(公告)日：2017-06-06

申请号：US14087459

申请日：2013-11-22

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16 ,  A61F2/90

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0088 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/142

Abstract: Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

公开(公告)号：US20240189121A1

公开(公告)日：2024-06-13

申请号：US18581322

申请日：2024-02-19

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61L31/022 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0088 ,  A61L33/064 ,  A61F2240/001 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/142

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US11903850B2

公开(公告)日：2024-02-20

申请号：US17818585

申请日：2022-08-09

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61L33/00 ,  A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61L31/022 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0088 ,  A61L33/064 ,  A61F2240/001 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/142

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20200323664A1

公开(公告)日：2020-10-15

申请号：US16913871

申请日：2020-06-26

Applicant: Covidien LP

Inventor： John Wainwright ,  Todd Mendelson ,  Kurt Haggstrom ,  Masoud Molaei ,  Victoria Schuman ,  Min-Shyan Sheu

IPC: A61F2/90 ,  A61F2/07 ,  B05D1/18 ,  B05D3/02 ,  B05D3/04

Abstract: Medical devices that include a tubular member with a plurality of braided filaments, each filament crossing another of the filaments at a respective crossing point forming sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm, the pores have an average pore size that is less than or equal to about 500 microns when the tubular member is in an expanded state, the filaments possessing antithrombogenic surfaces to increase antithrombogenicity of the medical device with pores substantially free of webs formed by antithrombogenic material, such that fewer than 5% of the crossing points have webs formed by antithrombogenic material thereby permitting the pores to be substantially free of webs.

公开(公告)号：US10258486B2

公开(公告)日：2019-04-16

申请号：US15584077

申请日：2017-05-02

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright, Jr. ,  Junwei Li

IPC: A61F2/82 ,  A61L31/00 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16 ,  A61F2/90 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06 ,  B05D1/18 ,  B05D3/14

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

公开(公告)号：US20150148882A1

公开(公告)日：2015-05-28

申请号：US14087459

申请日：2013-11-22

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/06 ,  A61F2/90 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/0088 ,  A61L33/064 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02 ,  B05D1/18 ,  B05D3/142

Abstract: Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

Abstract translation: 提供了将层应用于医疗设备和相关设备的方法。 这样的装置可以包括支架。 例如，该装置可以包括在侧壁中的侧壁和多个孔，其尺寸被设计成当管状构件定位时阻止血液通过侧壁流入动脉瘤至足以导致动脉瘤血栓形成和愈合的程度 在血管中并且与动脉瘤相邻。 该装置可以具有分布在装置的至少一部分上的抗血栓形成外层。

公开(公告)号：US11872244B2

公开(公告)日：2024-01-16

申请号：US16527740

申请日：2019-07-31

Applicant: Covidien LP

Inventor： Rachit Ohri ,  Phillip D. Blaskovich ,  Min-Shyan Sheu ,  Petra Brockfeld

IPC: A61K31/717 ,  A61K31/445 ,  A61K31/714 ,  A61K33/24 ,  A61K31/295 ,  A61K49/04 ,  A61L26/00 ,  A61K33/20 ,  A61K33/243

CPC classification number: A61K31/717 ,  A61K31/295 ,  A61K31/445 ,  A61K31/714 ,  A61K33/20 ,  A61K33/24 ,  A61K33/243 ,  A61K49/048 ,  A61L26/0023 ,  A61L26/0061 ,  A61L26/0066 ,  A61L2400/06 ,  A61L26/0023 ,  C08L1/04

Abstract: A method of treatment includes agitating a thixotropic oxidized cellulose solution; administering the agitated thixotropic oxidized cellulose solution to a target tissue site; and allowing the agitated thixotropic oxidized cellulose solution to gel at the target tissue site.

公开(公告)号：US20200022827A1

公开(公告)日：2020-01-23

申请号：US16586639

申请日：2019-09-27

Applicant: Covidien LP

Inventor： Xiaodong Ma ,  Min-Shyan Sheu ,  Lincoln Eramo ,  John Wainwright ,  Junwei Li

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/16 ,  A61F2/90 ,  A61L31/10 ,  A61F2/06 ,  A61L31/14 ,  A61L33/00 ,  A61L33/06

Abstract: Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.