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    SYSTEMS AND METHOD FOR CONTROLLING FLUID FLOW IN BIOREACTORS
    5.
    发明申请
    SYSTEMS AND METHOD FOR CONTROLLING FLUID FLOW IN BIOREACTORS 有权

    公开(公告)号：US20230031710A1

    公开(公告)日：2023-02-02

    申请号：US17782591

    申请日：2020-12-17

    Applicant: CYTIVA SWEDEN AB

    Inventor： Praveen Paul ,  Sahebagouda Alagur ,  Thomas Falkman ,  Prashanth Hosabettu Mohan

    IPC: C12M1/00 ,  C12M1/34

    Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.

    BIOREACTOR APPARATUS AND OPERATION METHOD THEREOF
    6.
    发明申请
    BIOREACTOR APPARATUS AND OPERATION METHOD THEREOF 有权

    公开(公告)号：US20220403318A1

    公开(公告)日：2022-12-22

    申请号：US17763860

    申请日：2020-10-01

    Applicant: Cytiva Sweden AB

    Inventor： Shivakumar Selvaraj ,  Bineesh Kandoth ,  Sahebagouda Alagur ,  Nagaraj Raghavendra Rao ,  Thomas Falkman

    IPC: C12M1/36 ,  C12M1/34 ,  C12M1/00

    Abstract: The present subject matter discloses a bioreactor apparatus. The bioreactor apparatus comprises a bioreactor vessel configured to culture cells. The bioreactor apparatus furthermore comprises a sensor configured to measure Dissolved Oxygen (DO) in the bioreactor vessel. The DO measurements comprise a plurality of DO values recorded at, at least, a plurality of time instances during operation of the bioreactor apparatus. The bioreactor apparatus furthermore comprises a controller configured to obtain the DO measurements. The controller furthermore is to determine, in real-time or approximately real-time, an oxygen mass transfer co-efficient (kLa) associated with the operation of the bioreactor apparatus. Furthermore, the controller is configured to control, in real-time or approximately real-time, at least one cell culture parameter associated with the operation of the bioreactor apparatus based on the kLa.

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