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公开(公告)号：US20210140558A1
公开(公告)日：2021-05-13
申请号：US17259709
申请日：2019-07-19
Applicant: Cytiva Sweden AB
Inventor： Prashanth Hosabettu Mohan , Ajit S. Vernekar , Praveen Paul , Krishnadev Madhavan Nair , Manjunath Bhat
Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.
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公开(公告)号：US11415241B2
公开(公告)日：2022-08-16
申请号：US17259709
申请日：2019-07-19
Applicant: Cytiva Sweden AB
Inventor： Prashanth Hosabettu Mohan , Ajit S. Vernekar , Praveen Paul , Krishnadev Madhavan Nair , Manjunath Bhat
Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.
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公开(公告)号：US20210395664A1
公开(公告)日：2021-12-23
申请号：US17277094
申请日：2019-09-20
Applicant: Cytiva Sweden AB
Inventor： Praveen Paul , Prashanth Hosabettu Mohan , Ajay Gore , Sahebagouda Alagur
Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).
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Patent Agency Ranking
公开(公告)号：US12169034B2
公开(公告)日：2024-12-17
申请号：US16077779
申请日：2017-02-21
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Sudheer Mygapula , Nachiket Karmarkar , Sasikumar Arumugam , Bashkar Hv , Ajit S. Vernekar , Nityananda Maiya , Prashanth Hosabettu Mohan , Sasi Kumar Nutalapati , Sameera Simha Hindupur , Shashidhar Hedge
Abstract: The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP=(Pinlet+Poutlet)/2−Pperm corresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein Pinlet is a pressure reading from the second pressure transducer, Poutlet is a pressure reading from the first pressure transducer and Pperm is a pressure reading from the third pressure transducer.
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公开(公告)号：US20230031710A1
公开(公告)日：2023-02-02
申请号：US17782591
申请日：2020-12-17
Applicant: CYTIVA SWEDEN AB
Inventor： Praveen Paul , Sahebagouda Alagur , Thomas Falkman , Prashanth Hosabettu Mohan
Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.
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公开(公告)号：US20210261900A1
公开(公告)日：2021-08-26
申请号：US17268486
申请日：2019-08-20
Applicant: Cytiva Sweden AB
Inventor： Anoop Bhargav , Praveen Paul , Prashanth Hosabettu Mohan , Ajay Gore , Pradeep Kumar , Victor Jose , Sahebagouda Alagur , Melissa Marie Semple , Mark David Roberts
Abstract: A method includes inducing a first quantity of a feed fluid (28) to flow along a first direction (72) from a bioreactor (12) to a tangential flow filter (16) to separate the first quantity of the feed fluid (28) into a permeate fluid (42) and a retentate fluid (48). Further, the control unit (66) is operated to control at least one feed flow control device (24, 26) to inhibit the flow of first quantity of the feed fluid (28). Furthermore, the control unit (66) is operated to control the at least one feed flow control device (24, 26) to direct at least one of further flow of a second quantity of the feed fluid (28) from the bioreactor (12), a portion of the permeate fluid (42), and a portion of a nutrient fluid, along a second direction (74) opposite to the first direction (72) via the tangential flow filter (16).
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公开(公告)号：US20250092349A1
公开(公告)日：2025-03-20
申请号：US18962844
申请日：2024-11-27
Applicant: Cytiva Sweden AB
Inventor： Praveen Paul , Prashanth Hosabettu Mohan , Ajay Gore , Sahebagouda Alagur
Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path.
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公开(公告)号：US12195715B2
公开(公告)日：2025-01-14
申请号：US17277094
申请日：2019-09-20
Applicant: Cytiva Sweden AB
Inventor： Praveen Paul , Prashanth Hosabettu Mohan , Ajay Gore , Sahebagouda Alagur
Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).
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