公开(公告)号：US20030008411A1

公开(公告)日：2003-01-09

申请号：US10116761

申请日：2002-04-03

Applicant: California Institute of Technology

Inventor： Michael Van Dam ,  Marc A. Unger ,  Stephen R. Quake

IPC: B01J019/00

CPC classification number: G01N15/06 ,  B01J19/0046 ,  B01J2219/00355 ,  B01J2219/00398 ,  B01J2219/00418 ,  B01J2219/00427 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B82Y30/00 ,  C40B40/06 ,  C40B40/10 ,  C40B50/14 ,  C40B60/14 ,  Y10T436/10 ,  Y10T436/25 ,  Y10T436/255 ,  Y10T436/2575

Abstract: The present invention provides a microfluidic device for synthesizing an array of compounds and methods for using the same. In particular, the microfluidic device of the present invention comprises a solid support base, an elastomeric layer attached to the solid support, and a plurality of flow channels located within the interface between the solid support and the elastomeric layer. In addition, the solid support comprises a functional group for forming a bond with a reactive reagent. In some embodiments, the microfluidic device further comprises a second plurality of flow channels that intersect the first plurality of flow channels. A plurality of control channels are also present in the microfluidic devices of the present invention. The control channels can be actuated to regulate flow of fluids within the flow channel(s).

Abstract translation: 本发明提供了用于合成化合物阵列的微流体装置及其使用方法。 特别地，本发明的微流体装置包括固体支撑基底，连接到固体支撑体的弹性体层，以及位于固体支撑体和弹性体层之间的界面内的多个流动通道。 此外，固体支持物包含与反应试剂形成键的官能团。 在一些实施例中，微流体装置还包括与第一多个流动通道相交的第二多个流动通道。 多个控制通道也存在于本发明的微流体装置中。 可以启动控制通道以调节流动通道内的流体的流动。