公开(公告)号：US20240001327A1

公开(公告)日：2024-01-04

申请号：US18036405

申请日：2021-10-06

Applicant: INOPLAZTECH CO., LTD.

Inventor： Deuk Yeon LEE ,  Chang Young LEE ,  Ja Eun LEE ,  Yeon Bi HAN

IPC: B01J19/08 ,  B01J19/10 ,  B01J19/12 ,  H05H1/46

CPC classification number: B01J19/088 ,  B01J19/10 ,  B01J19/129 ,  H05H1/466 ,  B01J2219/0894 ,  B01J2219/00635

Abstract: A powder treatment plasma device according to the present invention maximizes processing capacity for performing processing all at once, by stacking a plurality of flat and porous filter electrodes, and thus improves processing efficiency. In addition, since vibration is applied to the filter electrodes by using a vibration generator while causing powder to be adsorbed on surfaces of the filter electrodes by using an adsorption means, the powder can be evenly dispersed on the surfaces of the filter electrodes and mixed, and thus the powder can be evenly surface-treated.

公开(公告)号：US20230338915A1

公开(公告)日：2023-10-26

申请号：US18026702

申请日：2021-09-20

Applicant: DSM IP ASSETS B.V.

Inventor： Radhika VAN DER HELM ,  Thomas WELLAUER ,  Andreas WERNLI ,  Peter CLAES

IPC: B01J19/02 ,  B01J19/00

CPC classification number: B01J19/02 ,  B01J19/002 ,  B01J2219/00331 ,  B01J2219/00353 ,  B01J2219/00601 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/0072 ,  B01J2219/0218 ,  B01J2219/0277

Abstract: The present invention relates to a method of reducing the deposit of metallic transition metal, particularly palladium, on a metal part in hydrogenation reactions using hydrogen and a heterogenous supported palladium catalyst. These metallic transition metal deposit, particularly palladium deposits, are particularly formed at areas which are exposed to high velocity and shear forces of the hydrogenation mixture comprising the transition metal catalyst, particularly palladium catalyst. They are significantly reduced or even avoided when the surface of the respective metal parts are coated by a plasma sprayed ceramic coating.

公开(公告)号：US20230338913A1

公开(公告)日：2023-10-26

申请号：US18319356

申请日：2023-05-17

Applicant: TWIST BIOSCIENCE CORPORATION

Inventor： William BANYAI ,  Bill James PECK ,  Andres FERNANDEZ ,  Siyuan CHEN ,  Pierre INDERMUHLE ,  Eugene P. MARSH

IPC: B01J19/00 ,  C12N15/10

CPC classification number: B01J19/0046 ,  C12N15/1093 ,  B01J2219/00596 ,  B01J2219/00722 ,  B01J2219/00497 ,  B01J2219/00585 ,  B01J2219/00317 ,  B01J2219/00511 ,  B01J2219/00522 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00662 ,  B01L3/50857

Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.

公开(公告)号：US11691118B2

公开(公告)日：2023-07-04

申请号：US16921712

申请日：2020-07-06

Applicant: Twist Bioscience Corporation

Inventor： William Banyai ,  Bill James Peck ,  Andres Fernandez ,  Siyuan Chen ,  Pierre Indermuhle ,  Eugene P. Marsh

IPC: B01J19/00 ,  C12N15/10 ,  B01L3/00

CPC classification number: B01J19/0046 ,  C12N15/1093 ,  B01J2219/00317 ,  B01J2219/00497 ,  B01J2219/00511 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00662 ,  B01J2219/00722 ,  B01L3/50857 ,  C12N15/1093 ,  C12Q2563/159 ,  C12Q2565/513 ,  C12Q2565/629

Abstract: Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.

公开(公告)号：US20180304221A1

公开(公告)日：2018-10-25

申请号：US15770299

申请日：2016-10-21

Applicant: 3dbiosurfaces Technologies, LLC

Inventor： Alan Gordon GOODYEAR ,  Barry BEROTH

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J19/00 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/163 ,  B81C1/00206

Abstract: An activated textured surface comprising a plurality of energetic moieties adapted to bind biomolecules on microfeatures and/or microstructures of the activated textured surface. The microfeatures and/or microstructures provide an increase in surface area. The activated textured surface may comprise microstructures without microfeatures, or in some cases, microstructures are disposed in and/or between at least a portion of the microfeatures. The activated textured surface may be a part of a microarray substrate. Activation of the surface molecules of the microfeatures and/or microstructures using electromagnetic radiation or plasma may be used to create the energetic moieties on the activated textured surface.

公开(公告)号：US20180266932A1

公开(公告)日：2018-09-20

申请号：US15571808

申请日：2016-04-29

Applicant: The European Union, represented by the European Commision

Inventor： Andrea VALSESIA ,  Cloé DESMET ,  Pascal COLPO ,  François ROSSI

IPC: G01N15/02

CPC classification number: G01N15/0227 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00635 ,  B01J2219/00637 ,  G01N15/00 ,  G01N15/0205 ,  G01N2015/0038

Abstract: A nanoparticle screening chip and a method using said chip allowing for determining physical properties of nanoparticles, wherein the screening chip comprises a substrate having a working surface divided into a plurality of areas, wherein (1) each of these areas presents different surface properties defined by surface energy component (d,b,a), the total free energy γTOT of the surface of each area being defined as follows: γTOT=γLW+2(γ+γ−)0.5, wherein the components are: γLW=dispersive component=d, γ+=electron acceptor component=b, γ−=electron donor component=a; and (2) each of these areas comprises a plurality of subareas, each subarea comprising an array of sub-micrometric holes or elongated grooves with a different aperture size (S1, S2, S3, . . . ).

公开(公告)号：US09358518B2

公开(公告)日：2016-06-07

申请号：US12845417

申请日：2010-07-28

Applicant: Kunihisa Nagino ,  Fumio Nakamura ,  Hitoshi Nobumasa

Inventor： Kunihisa Nagino ,  Fumio Nakamura ,  Hitoshi Nobumasa

IPC: C40B40/06 ,  C40B40/14 ,  B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00497 ,  B01J2219/00509 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/00731 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.)

公开(公告)号：US20160059202A1

公开(公告)日：2016-03-03

申请号：US14819173

申请日：2015-08-05

Applicant: University of Utah Research Foundation

Inventor： Alexander Chagovetz ,  Steven M. Blair ,  Colby Wilson

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00635 ,  B01J2219/00637

Abstract: Disclosed are high density microarrays and methods for making and using such microarrays. The microarrays of the present invention can have uniformly shaped and sized sensing zones and are designed to allow high-throughput detection assays with minimal noise.

Abstract translation: 公开了用于制造和使用这种微阵列的高密度微阵列和方法。 本发明的微阵列可以具有均匀成形和尺寸的感测区域，并且被设计为允许具有最小噪声的高通量检测分析。

公开(公告)号：US09050577B2

公开(公告)日：2015-06-09

申请号：US13395137

申请日：2010-09-09

Applicant: Hirofumi Yamano

Inventor： Hirofumi Yamano

IPC: B01J19/00 ,  C12Q1/68

CPC classification number: B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6834 ,  C12Q1/6837 ,  Y10T428/31721

Abstract: A solid support for maintaining a uniform spot shape while improving the capacity for immobilization of nucleic acids upon spotting of nucleic acids onto a solid support is provided. A substrate has a base material, an electrostatic layer formed on the base material in order to electrostatically attract nucleic acids, and carboxyl groups formed on the electrostatic layer, wherein the ratio, (COO peak intensity)/(C—C peak intensity) in the C1s spectra obtained by X-ray photoelectron spectrometry (XPS) performed for the surface of the substrate ranges from 0.10 to 0.20. The solid support for immobilizing nucleic acids is produced by active esterification of carboxyl groups of the substrate.

Abstract translation: 提供了用于保持均匀斑点形状的固体支持物，同时提高了将核酸固定在固体支持物上时固定核酸的能力。 基材具有基材，静电层，形成在基材上以静电吸引核酸，以及形成在静电层上的羧基，其中，（COO峰强度）/（C-C峰强度） 对于衬底表面进行的X射线光电子能谱（XPS）获得的C1s光谱范围为0.10〜0.20。 用于固定核酸的固体支持物通过底物的羧基的活性酯化产生。

公开(公告)号：US20150038368A1

公开(公告)日：2015-02-05

申请号：US14457014

申请日：2014-08-11

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Timothy Z. LIU ,  Jer-Kang Chen ,  Ronald Graham

IPC: C12Q1/68 ,  B01J19/00 ,  C12N15/10

CPC classification number: C12Q1/686 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00529 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00619 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/50851 ,  B01L3/5088 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0819 ,  C12N15/1093 ,  C40B50/18 ,  C40B80/00

Abstract: A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR.

Abstract translation: 一种用于在衬底上产生多核苷酸图案的方法，装置或系统。 该方法包括提供具有疏水表面的基底。 该方法还包括将聚苯乙烯部分与多核苷酸缀合并施加聚苯乙烯 - 多核苷酸缀合物，以在基底的疏水性表面上产生多个反应点。 一种装置包括在基底表面上具有至少一个聚苯乙烯 - 多核苷酸缀合物的底物。 系统可以分析聚苯乙烯 - 多核苷酸缀合物，并且系统可以进行PCR。