公开(公告)号：US09919140B2

公开(公告)日：2018-03-20

申请号：US14433583

申请日：2013-10-07

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA ,  DOHENY EYE INSTITUTE ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Mark S. Humayun ,  Karthik Murali ,  Ramiro Magalhaes Ribeiro ,  Yu-chong Tai ,  Nicholas Scianmarello

IPC分类号： A61M37/00 ,  A61F9/00 ,  C25B1/02 ,  C25B9/08 ,  A61M5/142

CPC分类号： A61M37/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M2005/14204 ,  A61M2205/3334 ,  A61M2210/0612 ,  C25B1/02 ,  C25B9/08

摘要： An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.

公开(公告)号：US20170348147A1

公开(公告)日：2017-12-07

申请号：US15685353

申请日：2017-08-24

申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

IPC分类号： A61F9/00 ,  A61N1/378 ,  A61N1/05 ,  A61M5/142 ,  A61M37/00 ,  A61N1/20

CPC分类号： A61F9/0017 ,  A61M5/14276 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/04 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/20 ,  A61N1/3787 ,  C25B1/04 ,  C25B9/00 ,  C25B15/02 ,  C25B15/08

摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

公开(公告)号：US20170071785A1

公开(公告)日：2017-03-16

申请号：US15261435

申请日：2016-09-09

申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

IPC分类号： A61F9/00 ,  A61N1/05 ,  A61M5/142 ,  A61M37/00

CPC分类号： A61F9/0017 ,  A61M5/14276 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/04 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/20 ,  A61N1/3787

摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

摘要翻译： 描述了可植入医疗装置。 可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。 小分子发生器包括电解质储存器和一组电极。 电解质储存器的第一部分对于预定类别的小分子是不可渗透的。 电解液储存器的第二部分对小分子是可渗透的。 该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。 至少一部分小分子扩散剂对小分子是可渗透的。

公开(公告)号：US10342698B2

公开(公告)日：2019-07-09

申请号：US15685353

申请日：2017-08-24

申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

IPC分类号： A61F9/00 ,  A61M5/142 ,  A61M37/00 ,  A61N1/05 ,  A61N1/378 ,  A61N1/20

摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

公开(公告)号：US09763825B2

公开(公告)日：2017-09-19

申请号：US15261435

申请日：2016-09-09

申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

IPC分类号： A61F9/00 ,  A61M5/142 ,  A61M37/00 ,  A61N1/05 ,  A61N1/378 ,  A61N1/20

CPC分类号： A61F9/0017 ,  A61M5/14276 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/04 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/20 ,  A61N1/3787

摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

公开(公告)号：US20150273197A1

公开(公告)日：2015-10-01

申请号：US14433583

申请日：2013-10-07

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA ,  DOHENY EYE INSTITUTE ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Mark S. Humayun ,  Karthik Murali ,  Ramiro Magalhaes Ribeiro ,  Yu-chong Tai ,  Nicholas Scianmarello

IPC分类号： A61M37/00 ,  C25B9/08 ,  C25B1/02

CPC分类号： A61M37/00 ,  A61F9/0017 ,  A61M5/14276 ,  A61M2005/14204 ,  A61M2205/3334 ,  A61M2210/0612 ,  C25B1/02 ,  C25B9/08

摘要： An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.

摘要翻译： 植入式氧合器可以具有适合于植入在人体内的人体内的构造，例如在人眼内。 可植入氧合器可以包括具有适于储存电解质的结构的电解质储存器和具有对电解质的一部分进行电解的结构的电解系统，从而在电解系统的区域中产生氧。

公开(公告)号：US09655774B2

公开(公告)日：2017-05-23

申请号：US14744439

申请日：2015-06-19

申请人： California Institute of Technology ,  University of Southern California

发明人： Yu-Chong Tai ,  Nicholas Scianmarello ,  Dongyang Kang ,  Jungwook Park ,  Mark S. Humayun ,  Karthik Murali ,  Amir H. Kashani ,  Hossein Nazari Khanamiri

IPC分类号： A61M5/00 ,  A61F9/00 ,  B29C39/10 ,  B29C65/00 ,  B29C65/02 ,  B29K83/00 ,  B29C41/36 ,  B29L31/00

CPC分类号： A61F9/0017 ,  A61F2240/001 ,  A61F2250/0068 ,  B29C39/10 ,  B29C41/36 ,  B29C65/02 ,  B29C66/1142 ,  B29C66/3242 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73754 ,  B29C66/919 ,  B29C66/949 ,  B29K2083/005 ,  B29L2031/7548

摘要： A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.

公开(公告)号：US20150366707A1

公开(公告)日：2015-12-24

申请号：US14744439

申请日：2015-06-19

申请人： California Institute of Technology ,  University of Southern California

发明人： Yu-Chong Tai ,  Nicholas Scianmarello ,  Dongyang Kang ,  Jungwook Park ,  Mark S. Humayun ,  Karthik Murali ,  Amir H. Kashani ,  Hossein Nazari Khanamiri

IPC分类号： A61F9/00 ,  B29C39/10

CPC分类号： A61F9/0017 ,  A61F2240/001 ,  A61F2250/0068 ,  B29C39/10 ,  B29C41/36 ,  B29C65/02 ,  B29C66/1142 ,  B29C66/3242 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73754 ,  B29C66/919 ,  B29C66/949 ,  B29K2083/005 ,  B29L2031/7548

摘要： A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.

摘要翻译： 具有通过非渗透性套管连接到排出囊的可渗透袋的医疗装置与制造过程和手术植入方法一起被描述。 装置的可渗透部分具有尺寸适于对预定类型的小分子例如氧气，一氧化二氮或其它治疗剂可渗透的孔。 一旦被吸收在设备内部，小分子就被小分子的浓度梯度被动地运送到排出囊。 套管中可以包括金属管或其它条，以帮助外科医生将装置定向在体内。