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    IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER
    3.
    发明申请
    IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER 有权
    可植入氧气发生器和运输机

    公开(公告)号：US20170071785A1

    公开(公告)日：2017-03-16

    申请号：US15261435

    申请日：2016-09-09

    申请人： California Institute of Technology ,  University of Southern California ,  Doheny Eye Institute

    发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Karthik Murali ,  Mark S. Humayun ,  Ramiro Magalhaes Ribeiro

    IPC分类号： A61F9/00 ,  A61N1/05 ,  A61M5/142 ,  A61M37/00

    CPC分类号： A61F9/0017 ,  A61M5/14276 ,  A61M37/00 ,  A61M2005/14204 ,  A61M2205/04 ,  A61M2210/0612 ,  A61N1/0543 ,  A61N1/20 ,  A61N1/3787

    摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

    摘要翻译： 描述了可植入医疗装置。 可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。 小分子发生器包括电解质储存器和一组电极。 电解质储存器的第一部分对于预定类别的小分子是不可渗透的。 电解液储存器的第二部分对小分子是可渗透的。 该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。 至少一部分小分子扩散剂对小分子是可渗透的。

    Implantable extracompartmental pressure sensor
    7.
    发明授权
    Implantable extracompartmental pressure sensor 有权

    公开(公告)号：US11122975B2

    公开(公告)日：2021-09-21

    申请号：US15948187

    申请日：2018-04-09

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Damien C. Rodger ,  Yu-Chong Tai ,  Mark S. Humayun ,  Aubrey M. Shapero ,  Abhinav Agarwal ,  Azita Emami

    IPC分类号： A61B3/16 ,  A61F9/007 ,  A61M1/00 ,  A61M27/00

    摘要： A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.

    Contact lens with metered liquid system
    8.
    发明授权
    Contact lens with metered liquid system 有权

    公开(公告)号：US10768444B2

    公开(公告)日：2020-09-08

    申请号：US16017667

    申请日：2018-06-25

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Charles M. T. DeBoer ,  Mark S. Humayun

    IPC分类号： G02C7/00 ,  G02C7/02 ,  G02C7/04 ,  G02C7/08 ,  A61K9/00

    摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

    CONTACT LENS WITH METERED LIQUID SYSTEM
    9.
    发明申请
    CONTACT LENS WITH METERED LIQUID SYSTEM 审中-公开
    带液体液体系统的接触镜

    公开(公告)号：US20160109726A1

    公开(公告)日：2016-04-21

    申请号：US14881935

    申请日：2015-10-13

    申请人： California Institute of Technology ,  University of Southern California

    发明人： Yu-Chong Tai ,  Nicholas E. Scianmarello ,  Charles M. T. DeBoer ,  Mark S. Humayun

    IPC分类号： G02C7/04 ,  A61K9/00 ,  G02C7/08

    CPC分类号： G02C7/049 ,  A61K9/0051 ,  G02C7/04 ,  G02C7/041 ,  G02C7/085

    摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.

    摘要翻译： 描述了具有与流量调节器连接到通道的液体储存器的隐形眼镜流体输送装置。 本文描述了其他眼睛水合和可变屈光力隐形眼镜。 还描述了具有通过流量调节器连接到通道的液体储存容器的可植入液体输送装置。 这些装置和装置可用于对象内治疗液体的特定目标递送。 在一些实施例中，装置包括致动室，其提供将流体释放到目标区域（例如眼睛）中的驱动力。 本文所述的致动室可以包含相变材料或渗透室或其组合以驱动流体的释放。