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公开(公告)号：US20170348147A1
公开(公告)日：2017-12-07
申请号：US15685353
申请日：2017-08-24
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787 , C25B1/04 , C25B9/00 , C25B15/02 , C25B15/08
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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公开(公告)号：US20170071785A1
公开(公告)日：2017-03-16
申请号：US15261435
申请日：2016-09-09
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
摘要翻译： 描述了可植入医疗装置。 可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。 小分子发生器包括电解质储存器和一组电极。 电解质储存器的第一部分对于预定类别的小分子是不可渗透的。 电解液储存器的第二部分对小分子是可渗透的。 该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。 至少一部分小分子扩散剂对小分子是可渗透的。
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公开(公告)号：US10342698B2
公开(公告)日：2019-07-09
申请号：US15685353
申请日：2017-08-24
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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公开(公告)号：US09763825B2
公开(公告)日：2017-09-19
申请号：US15261435
申请日：2016-09-09
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
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公开(公告)号：US20200260946A1
公开(公告)日：2020-08-20
申请号：US16786377
申请日：2020-02-10
摘要： A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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公开(公告)号：US10768444B2
公开(公告)日：2020-09-08
申请号：US16017667
申请日：2018-06-25
摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
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公开(公告)号：US20160109726A1
公开(公告)日：2016-04-21
申请号：US14881935
申请日：2015-10-13
CPC分类号： G02C7/049 , A61K9/0051 , G02C7/04 , G02C7/041 , G02C7/085
摘要： A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
摘要翻译： 描述了具有与流量调节器连接到通道的液体储存器的隐形眼镜流体输送装置。 本文描述了其他眼睛水合和可变屈光力隐形眼镜。 还描述了具有通过流量调节器连接到通道的液体储存容器的可植入液体输送装置。 这些装置和装置可用于对象内治疗液体的特定目标递送。 在一些实施例中，装置包括致动室，其提供将流体释放到目标区域（例如眼睛）中的驱动力。 本文所述的致动室可以包含相变材料或渗透室或其组合以驱动流体的释放。
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公开(公告)号：US11730358B2
公开(公告)日：2023-08-22
申请号：US16786377
申请日：2020-02-10
CPC分类号： A61B3/101 , A61B5/6821 , A61B5/6867 , A61B10/0045 , G01F22/00 , G01G19/00 , G01N1/10 , G01N30/02 , G01N33/4875 , A61B2010/0067 , G01N2030/027
摘要： A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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公开(公告)号：US11523939B2
公开(公告)日：2022-12-13
申请号：US16418899
申请日：2019-05-21
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US20230337906A1
公开(公告)日：2023-10-26
申请号：US18344118
申请日：2023-06-29
CPC分类号： A61B3/101 , G01N30/02 , G01G19/00 , G01F22/00 , G01N1/10 , A61B5/6821 , A61B10/0045 , A61B5/6867 , G01N33/4875 , A61B2010/0067 , G01N2030/027
摘要： A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.
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