公开(公告)号：US20170354967A1

公开(公告)日：2017-12-14

申请号：US15679111

申请日：2017-08-16

申请人： CapitalBio Corporation ,  Tsinghua University

发明人： Shengce TAO ,  Jing CHENG ,  Xuemei MA ,  Qiong ZHANG ,  Yuxiang ZHOU

IPC分类号： B01L3/00 ,  C12Q1/68 ,  C40B40/06 ,  B01L7/00 ,  C40B60/14

CPC分类号： B01L3/508 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00722 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/163 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  C12Q2547/101 ,  C12Q2531/131

摘要： This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and the hybridization signal can be acquired if desirable, in the controllably closed space without any material exchange between the controllably closed space and the outside environment. Methods for analyzing a nucleic acid using the lab-on-chip system is also provided.