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公开(公告)号：US09446136B2
公开(公告)日：2016-09-20
申请号：US14929115
申请日：2015-10-30
发明人： David M. Gravett , George Y. Daniloff , Pingren He
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
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公开(公告)号：US20150352142A1
公开(公告)日：2015-12-10
申请号：US14760447
申请日：2014-01-10
发明人： David M. Gravett , Pingren He
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/06 , A61K31/573 , A61K31/58 , A61K31/728 , A61K47/10 , A61K47/36 , C08B37/0072 , C08L5/08 , A61K2300/00 , C08L5/02 , C08L1/286
摘要： Provided herein are hyaluronic-acid based compositions comprising a hyaluronic acid-based polymer and a corticosteroid in the presence of a stabilizing amount of one or more stabilizing additives and related methods. The resulting compositions substantially retain their viscoelastic and related rheolotical properties under conditions of storage, processing, and use.
摘要翻译： 本文提供了在稳定量的一种或多种稳定添加剂和相关方法的存在下，包含透明质酸基聚合物和皮质类固醇的基于透明质酸的组合物。 所得组合物在储存，加工和使用的条件下基本上保持其粘弹性和相关的流变性能。
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公开(公告)号：US20170239358A1
公开(公告)日：2017-08-24
申请号：US15277928
申请日：2016-09-27
发明人： David M. Gravett , George Y. Daniloff , Pingren He
IPC分类号： A61K47/36 , A61K47/34 , A61L24/00 , C08B37/08 , A61L24/04 , A61L24/08 , A61K9/06 , A61K31/58
CPC分类号： A61K47/36 , A61K9/06 , A61K31/58 , A61K31/728 , A61K31/765 , A61K45/06 , A61K47/34 , A61L24/0015 , A61L24/0042 , A61L24/043 , A61L24/046 , A61L24/08 , A61L26/0019 , A61L26/0023 , A61L26/008 , A61L27/18 , A61L27/20 , A61L27/52 , A61L27/54 , A61L31/042 , A61L31/06 , A61L31/145 , A61L31/16 , A61L2300/222 , A61L2300/604 , A61L2300/802 , A61L2400/06 , C08B37/0072 , C08L5/08 , C08L71/02
摘要： The present application provides rapid-gelling, sprayable hyaluronic-acid based compositions, kits, related methods, precursor formulations, and uses thereof.
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公开(公告)号：US20160193342A1
公开(公告)日：2016-07-07
申请号：US14929115
申请日：2015-10-30
发明人： David M. Gravett , George Y. Daniloff , Pingren He
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
摘要翻译： 本申请提供了包含具有低水平的官能团改性的透明质酸的组合物，由这种轻度改性的透明质酸与合适的二官能或多官能交联剂的受控反应形成的混合物，以及水凝胶前体组合物和所得的水凝胶。 组合物轻度交联并且在体内注射时具有低促炎特性，并且可以用作例如医疗装置，生物医学粘合剂和密封剂，以及用于生物活性剂的局部递送以及其它用途。
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公开(公告)号：US09192678B2
公开(公告)日：2015-11-24
申请号：US14333426
申请日：2014-07-16
发明人： David M. Gravett , George Y. Daniloff , Pingren He
IPC分类号： A61K47/36 , A61K31/573 , A61K45/06 , A61K9/14 , A61L27/26 , A61L27/52 , C08B37/08 , C08J3/075
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
摘要翻译： 本申请提供了包含具有低水平的官能团改性的透明质酸的组合物，由这种轻度改性的透明质酸与合适的二官能或多官能交联剂的受控反应形成的混合物，以及水凝胶前体组合物和所得的水凝胶。 组合物轻度交联并且在体内注射时具有低促炎特性，并且可以用作例如医疗装置，生物医学粘合剂和密封剂，以及用于生物活性剂的局部递送以及其它用途。
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公开(公告)号：US09980977B2
公开(公告)日：2018-05-29
申请号：US15264550
申请日：2016-09-13
发明人： David M. Gravett , George Y. Daniloff , Pingren He
IPC分类号： A61K31/58 , A61K47/10 , A61K9/06 , A61K47/02 , A61K9/00 , A61K35/00 , A61K47/36 , A61K9/10 , C08J3/075 , C08B37/08
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
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公开(公告)号：US20170224708A1
公开(公告)日：2017-08-10
申请号：US15264550
申请日：2016-09-13
发明人： David M. Gravett , George Y. Daniloff , Pingren He
IPC分类号： A61K31/58 , A61K47/10 , A61K9/06 , C08J3/075 , A61K47/02 , A61K9/00 , A61K35/00 , C08B37/08 , A61K47/36 , A61K9/10
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
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公开(公告)号：US20140328926A1
公开(公告)日：2014-11-06
申请号：US14333426
申请日：2014-07-16
发明人： David M. Gravett , George Y. Daniloff , Pingren He
IPC分类号： A61K47/36 , A61K31/573 , A61K45/06 , A61K9/14
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
摘要翻译： 本申请提供了包含具有低水平的官能团改性的透明质酸的组合物，由这种轻度改性的透明质酸与合适的二官能或多官能交联剂的受控反应形成的混合物，以及水凝胶前体组合物和所得的水凝胶。 组合物轻度交联并且在体内注射时具有低促炎特性，并且可以用作例如医疗装置，生物医学粘合剂和密封剂，以及用于生物活性剂的局部递送以及其它用途。
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