公开(公告)号：US20150081009A1

公开(公告)日：2015-03-19

申请号：US14551338

申请日：2014-11-24

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/95

CPC classification number: A61F2/246 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2439 ,  A61F2/95 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.

Abstract translation: 描述了一种治疗系统和治疗方法，其具有能够定位和展开的植入物，然后去除部署以允许植入物的重新定位。 该系统包括自动扩张的医用植入物，其在从径向压实状态径向膨胀时纵向缩短，构造成将植入物附接到输送装置的远端安装件的远端界面，以及被配置为将植入物附接到近端 输送装置的安装。 将远端安装件纵向远离近侧安装件移动，对植入物施加纵向张力，使得植入物纵向膨胀并径向收缩，并使远端安装件向近端安装件移动，减小了植入物中的纵向张力，使植入物径向扩张 一个完全扩张的状态。

公开(公告)号：US20150066140A1

公开(公告)日：2015-03-05

申请号：US14538638

申请日：2014-11-11

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/24 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/95 ,  A61F2002/9522 ,  A61F2002/9534 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2250/001

Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.

Abstract translation: 用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。 支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。 为了交付，植入物在输送装置内压实并固定在一端。 在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。 如果需要，植入物可以至少部分地重新固定并重新定位。

公开(公告)号：US20140309731A1

公开(公告)日：2014-10-16

申请号：US14313160

申请日：2014-06-24

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/24 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/95 ,  A61F2002/9522 ,  A61F2002/9534 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2250/001

Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.

Abstract translation: 用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。 支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。 为了交付，植入物在输送装置内压实并固定在一端。 在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。 如果需要，植入物可以至少部分地重新固定并重新定位。

公开(公告)号：US08911455B2

公开(公告)日：2014-12-16

申请号：US13725896

申请日：2012-12-21

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61B17/10 ,  A61F2/06 ,  A61F2/24 ,  A61F2/95

CPC classification number: A61F2/246 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2439 ,  A61F2/95 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9517 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067

Abstract: A medical treatment system and method of treatment is described having an implant that can be positioned and deployed, then undeployed to allow repositioning of the implant. The system includes a self-expanding medical implant that longitudinally foreshortens upon radially expanding from a radially compacted state, a distal interface configured to attach the implant to a distal mount of a delivery device, and a proximal interface configured to attach the implant to a proximal mount of the delivery device. Moving the distal mount longitudinally away from the proximal mount applies a longitudinal tension to the implant causing the implant to expand longitudinally and contract radially, and moving the distal mount toward the proximal mount reduces a longitudinal tension in the implant allowing the implant to expand radially toward a fully expanded state.

Abstract translation: 描述了一种治疗系统和治疗方法，其具有能够定位和展开的植入物，然后去除部署以允许植入物的重新定位。 该系统包括自动扩张的医用植入物，其在从径向压实状态径向膨胀时纵向缩短，构造成将植入物附接到输送装置的远端安装件的远端界面，以及被配置为将植入物附接到近端 输送装置的安装。 将远端安装件纵向远离近侧安装件移动，对植入物施加纵向张力，使得植入物纵向膨胀并径向收缩，并使远端安装件向近端安装件移动，减小了植入物中的纵向张力，使植入物径向扩张 一个完全扩张的状态。

公开(公告)号：US20140277422A1

公开(公告)日：2014-09-18

申请号：US14197639

申请日：2014-03-05

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： J. Brent Ratz ,  Arshad Quadri ,  Luca Pesce

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2457 ,  A61F2220/0025 ,  A61F2230/0041 ,  A61F2230/0065

Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity, and an outer skirt positioned annularly around an exterior of the expandable frame. In some embodiments, the outer skirt can extend outward from the frame and be secured to an outwardly extending anchor on the frame to create an axial barrier to fluid flow exterior to the frame when deployed within the body cavity.

Abstract translation: 假体可以被构造成在部署在体腔内时抓住腔内组织，并且防止围绕假体外部的流体的轴向流动。 假体可以包括可扩张的框架，其被配置为径向地膨胀和收缩以在体腔内展开，以及环形地围绕可扩张框架的外部定位的外裙部。 在一些实施例中，外裙部可以从框架向外延伸并且被固定到框架上的向外延伸的锚固件，以在展开在体腔内时产生对框架外部的流体流动的轴向屏障。

公开(公告)号：US08795356B2

公开(公告)日：2014-08-05

申请号：US14186957

申请日：2014-02-21

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/24 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/95 ,  A61F2002/9522 ,  A61F2002/9534 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2250/001

Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.

Abstract translation: 用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。 支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。 为了交付，植入物在输送装置内压实并固定在一端。 在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。 如果需要，植入物可以至少部分地重新固定并重新定位。

公开(公告)号：US20130184813A1

公开(公告)日：2013-07-18

申请号：US13786083

申请日：2013-03-05

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/24 ,  A61F2/2403 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/848 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/0013 ,  A61F2230/0054 ,  Y10T29/49426

Abstract: A prosthesis can be configured to be deployed within a body cavity. The prosthesis has an expandable frame, a plurality of proximal anchors, and a plurality of distal anchors, where the various anchors are connected to the frame. Radial expansion of the frame can cause the ends of the proximal anchors and the ends of the distal anchors to draw closer together.

Abstract translation: 假体可被配置成在体腔内展开。 假体具有可扩张框架，多个近端锚固件和多个远端锚固件，其中各种锚固件连接到框架。 框架的径向膨胀可导致近端锚固件的端部和远端锚固件的端部更靠近在一起。

公开(公告)号：US20130144381A1

公开(公告)日：2013-06-06

申请号：US13756424

申请日：2013-01-31

Applicant: CARDIAQ VALVE TECHNOLOGIES, INC.

Inventor： Arshad Quadri ,  J. Brent Ratz

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0041 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/008

Abstract: A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.

公开(公告)号：US20130144378A1

公开(公告)日：2013-06-06

申请号：US13755406

申请日：2013-01-31

Applicant: CARDIAQ VALVE TECHNOLOGIES, INC.

Inventor： Arshad Quadri ,  J. Brent Ratz ,  Robrecht Michiels

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2439 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0039 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

Abstract: A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.

Abstract translation: 替换心脏瓣膜具有被构造成接合天然瓣膜环的可膨胀框架和安装到可扩张框架的阀体。 阀体可以具有多个阀单元，其构造成打开以允许在第一方向上流动并且彼此接合，以便关闭并防止在第二方向上流动，第二方向与第一方向相反。

公开(公告)号：US20130138203A1

公开(公告)日：2013-05-30

申请号：US13747270

申请日：2013-01-22

Applicant: CardiAQ Valve Technologies, Inc.

Inventor： Arshad Quadri

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/2418 ,  A61F2/915 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/0016 ,  A61F2230/0013 ,  A61F2230/0054

Abstract: An expandable vascular stent includes an m×n array of ovals formed in a cylinder, m being the number of columns of ovals in the circumferential direction and n being the number of rows of ovals in the axial direction, and a plurality of prongs extending inwardly from the outer ends of respective ovals in rows 1 and n of the m×n array, and being arranged in facing pairs extending from axially-aligned ovals. The cylinder is expandable from an initial diameter to a pre-determined final diameter, wherein an increase in the diameter of the stent results in a substantial decrease in the length of the stent. The tube and the prongs can be made of surgical stainless steel, the tube being expandable using an angioplasty balloon; or the tube and the prongs can be made of a memory metal and the tube is self-expanding.

Abstract translation: 可扩张血管支架包括在气缸中形成的椭圆形的m×n阵列，m是圆周方向上椭圆的列数，n是椭圆形在轴向方向上的行数，以及向内延伸的多个尖头 从m×n阵列的行1和n中的相应椭圆形的外端开始，并且以从轴向对齐的椭圆形延伸的面对对布置。 圆柱体从初始直径扩展到预定的最终直径，其中支架直径的增加导致支架长度的显着减小。 管和插脚可以由手术不锈钢制成，管可以使用血管成形术气囊扩张; 或者管子和插脚可以由记忆金属制成，并且管子是自膨胀的。