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    METHOD AND APPARATUS FOR DIRECTED PROPAGATION OF NEURAL STIMULATION
    1.
    发明申请
    METHOD AND APPARATUS FOR DIRECTED PROPAGATION OF NEURAL STIMULATION 审中-公开

    公开(公告)号：US20200086113A1

    公开(公告)日：2020-03-19

    申请号：US16591263

    申请日：2019-10-02

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Manfred Franke ,  David J. Ternes ,  Juan Gabriel Hincapie Ordonez ,  Stephen B. Ruble ,  Jason J. Hamann ,  Kevin J. Mohsenian ,  Jack Gordon

    IPC: A61N1/05

    Abstract: A neural stimulation system delivers neural stimulation to a target nerve with control of direction of propagation of evoked neural signals in one or more fiber types of the target nerve using electrode configuration, thereby providing effective therapy while minimizing unintended effects. In various embodiments, mechanical parameters of a multi-polar electrode are determined to provide directed propagation of the neural stimulation by effecting neural conduction block in or near the stimulation site. In various embodiments, the electrode includes a cathode for evoking action potentials and a plurality of anodes for blocking the propagation of the evoked action potentials in specified direction(s) and fiber type(s) while minimizing the formation of virtual cathodes.

    Depletion block to block nerve communication
    3.
    发明授权
    Depletion block to block nerve communication 有权

    公开(公告)号：US10201709B2

    公开(公告)日：2019-02-12

    申请号：US14597137

    申请日：2015-01-14

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Manfred Franke ,  David J. Ternes ,  Juan Gabriel Hincapie Ordonez ,  Stephen B. Ruble ,  Jason J. Hamann ,  Arjun D. Sharma

    IPC: A61B18/12 ,  A61N1/36 ,  A61N1/05 ,  A61B18/00 ,  A61N1/372 ,  A61N1/378 ,  A61B18/14 ,  A61B18/20

    Abstract: An example of a system may include a depletion block neural stimulator and a depletion block controller. The depletion block neural stimulator may be configured to deliver a depletion block stimulation to a nerve. The depletion block stimulation may include a series of pulses at a pulse frequency within a range between about 100 Hz to about 1000 Hz. The depletion block controller may be configured to communicate with the depletion block neural stimulator and control the depletion block stimulation. The depletion block controller may be configured to receive a start depletion block signal and respond to the received start depletion block signal by initiating the delivery of the depletion block stimulation to the nerve, and the depletion block controller may be configured to receive a stop depletion block signal and respond to the received stop depletion block signal by terminating the delivery of the depletion block stimulation to the nerve.

    Dosed delivery of autonomic modulation therapy
    4.
    发明授权
    Dosed delivery of autonomic modulation therapy 有权

    公开(公告)号：US11931580B2

    公开(公告)日：2024-03-19

    申请号：US16526750

    申请日：2019-07-30

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： David J. Ternes ,  Jason J. Hamann ,  Stephen B. Ruble ,  Juan Gabriel Hincapie Ordonez ,  Manfred Franke

    IPC: A61N1/372 ,  A61N1/36

    CPC classification number: A61N1/36135 ,  A61N1/36114 ,  A61N1/3727

    Abstract: An example of a method embodiment may include receiving a user programmable neural stimulation (NS) dose for an intermittent neural stimulation (INS) therapy, and delivering the INS therapy with the user programmable NS dose to an autonomic neural target of a patient. Delivering the INS therapy may include delivering NS bursts, and delivering the NS bursts may include delivering a number of NS pulses per cardiac cycle during a portion of the cardiac cycles and not delivering NS pulses during a remaining portion of the cardiac cycles. The method may further include sensing cardiac events within the cardiac cycles, and controlling delivery of the user programmable NS dose of INS therapy using the sensed cardiac events to time delivery of the number of NS pulses per cardiac cycle to provide the user programmable NS dose. The user programmable NS dose may determine the number of NS pulses per cardiac cycle.

    Intuited delivery of autonomic modulation therapy
    5.
    发明授权
    Intuited delivery of autonomic modulation therapy 有权
    引导自主调节治疗

    公开(公告)号：US09370659B2

    公开(公告)日：2016-06-21

    申请号：US14557707

    申请日：2014-12-02

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Manfred Franke ,  Stephen B. Ruble ,  David J. Ternes ,  Juan Gabriel Hincapie Ordonez ,  Jason J. Hamann

    IPC: A61N1/372 ,  A61N1/36

    CPC classification number: A61N1/36114 ,  A61N1/36117 ,  A61N1/36175 ,  A61N1/36178

    Abstract: An example of a method embodiment may deliver intermittent neural stimulation (INS) therapy to an autonomic neural target of a patient. The INS therapy includes neural stimulation (NS) ON times alternating with NS OFF times, and includes at least one NS burst of NS pulses during each of the NS ON times. For a given NS OFF time and subsequent NS ON time, delivering INS therapy may include monitoring a plurality of cardiac cycles during the NS OFF time, using the monitored plurality of cardiac cycles to predict cardiac event timing during the subsequent NS ON time, and controlling delivery of the INS therapy using the predicted cardiac event timing to time NS burst delivery of at least one NS burst for the subsequent NS ON time based on the predicted cardiac event timing.

    Abstract translation: 方法实施例的示例可将间歇性神经刺激（INS）治疗递送到患者的自主神经靶标。 INS治疗包括与NS OFF时间交替的神经刺激（NS）ON时间，并且在每个NS ON时间期间包括至少一个NS脉冲串NS脉冲。 对于给定的NS OFF时间和随后的NS ON时间，递送INS治疗可以包括在NS OFF时间期间监测多个心动周期，使用所监视的多个心动周期来预测随后的NS ON时间期间的心脏事件定时，以及控制 基于所预测的心脏事件定时，使用所预测的心脏事件定时至NS突发递送至少一个NS突发以用于随后的NS导通时间的INS治疗的递送。

    DEPLETION BLOCK TO BLOCK NERVE COMMUNICATION
    9.
    发明申请
    DEPLETION BLOCK TO BLOCK NERVE COMMUNICATION 审中-公开
    阻塞块到神经通信

    公开(公告)号：US20150202441A1

    公开(公告)日：2015-07-23

    申请号：US14597137

    申请日：2015-01-14

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Manfred Franke ,  David J. Ternes ,  Juan Gabriel Hincapie Ordonez ,  Stephen B. Ruble ,  Jason J. Hamann ,  Arjun D. Sharma

    IPC: A61N1/36 ,  A61B18/12

    CPC classification number: A61N1/3611 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/20 ,  A61B2018/00577 ,  A61B2018/00595 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36053 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36117 ,  A61N1/36128 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/3787

    Abstract: An example of a system may include a depletion block neural stimulator and a depletion block controller. The depletion block neural stimulator may be configured to deliver a depletion block stimulation to a nerve. The depletion block stimulation may include a series of pulses at a pulse frequency within a range between about 100 Hz to about 1000 Hz. The depletion block controller may be configured to communicate with the depletion block neural stimulator and control the depletion block stimulation. The depletion block controller may be configured to receive a start depletion block signal and respond to the received start depletion block signal by initiating the delivery of the depletion block stimulation to the nerve, and the depletion block controller may be configured to receive a stop depletion block signal and respond to the received stop depletion block signal by terminating the delivery of the depletion block stimulation to the nerve.

    Abstract translation: 系统的示例可以包括耗尽块神经刺激器和耗尽块控制器。 耗尽块神经刺激器可以被配置为向神经递送消耗块刺激。 耗尽块刺激可以包括脉冲频率在约100Hz至约1000Hz范围内的一系列脉冲。 耗尽块控制器可以被配置为与耗尽块神经刺激器通信并且控制消耗块刺激。 耗尽块控制器可以被配置为接收开始耗尽块信号并且通过启动对神经的耗尽块刺激的传递来响应于接收的开始耗尽块信号，并且耗尽块控制器可以被配置为接收停止耗尽块 信号并且通过终止对神经的耗尽块刺激的传递来响应所接收到的停止耗尽块信号。

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